Scientific Discovery

Influential articles for the 65th anniversary of the Lindau Nobel Laureate Meeting

Virtual special issue pays homage to the historic gatherings, attended by 65 Nobel laureates this year

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<strong>The Nobel Laureates take the stage for the opening ceremony. </strong>The tradition of Lindau Nobel Laureate Meetings is unique in fostering a dialogue between distinguished Nobel laureates and young scientists from all over the globe. The 65th anniversary event was devoted to interdisciplinary exchange and to present a laureate-driven declaration on global warming. (Photos by Thomas Schwarz-Romond)

June 28, 2015 marked an auspicious date for the scientific community: the 65th anniversary of the Lindau Nobel Laureate Meetings on the shores of Lake Constance, Germany. With 65 Nobel laureates in attendance — to celebrate by educating and inspiring junior researchers from around the globe — it was a remarkable occasion.

Emma Beckett, a PhD scholar in Food Science at the University of Newcastle and CSIRO in Australia, interviews Prof. Ada Yonath, a 2009 Nobel laureate in chemistry.Inspired by the scientific and societal discussion at this year’s meeting, Elsevier editors have selected articles that have made an outsized impact on the progress of science and made them freely available.

Originally created as a venue for German scientists to reconnect with the international scientific community after the Second World War, the Lindau Nobel Laureate Meetings follow a straightforward, highly successful strategy: introduce the world’s most distinguished scientists to select early-career researchers. Each year, 600 junior researchers meet with Nobel laureates for a week of lectures, master classes, scientific breakfasts, and panel discussions in Lindau, where they exchange ideas, socialize, and forge new friendships and long-term international collaborations.

With societal and economic conflicts on the rise around the world, Lindau’s original concept is more relevant than ever: to foster a cross-generational, international dialogue that can recognize, address, and help solve challenges that respect neither national, religious nor gender barriers –issues such as climate change, poverty, sustainable food supply, access to education, and the need for technologies that can ensure the integrity and future of our planet.

Dr. Michael J. Bishop, who shared the 1989 Nobel Prize in Physiology or Medicine with Dr. Harald E. Varmus, talks about elements of discovery. Signaling their ongoing commitment to effecting positive change, the 65 Nobel laureates issued the Mainau Declaration 2015 on Climate Change at this year’s gathering. “With this declaration, we outline the scale of the threat of climate change, and we provide the best possible advice,” said Prof. Brian P. Schmidt, 2011 Nobel laureate in Physics and a spokesperson for the Mainau Declaration.

This significant result knows only a single precedent: the 1955 Mainau Declaration, when a group of 18 Nobel laureates took a stand against the use of nuclear weapons.

Sixty-five years after their first installment, the Lindau Nobel Laureate Meetings continue to create an unforgettable, intellectually stimulating atmosphere.

We hope Elsevier’s complimentary selection of influential articles — featuring studies in physiology, medicine, chemistry and physics from a variety of authors across Elsevier’s journals — honor the Lindau Nobel Meetings’ innumerable successes. And we hope these valuable contributions reflect Elsevier’s commitment to support scientists in making their research available to the scientific community and the public.

Virtual Special Issue: influential articles to celebrate the 65th anniversary of the Lindau Nobel Laureate Meetings

This collection of influential articles published by Elsevier is intended to reflect the interdisciplinary spirit of the 65thLindau Nobel Laureate Meeting June 28 to July 3, 2015. These articles are freely available until January 22, 2016.

Physiology or Medicine

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185Cornelia I. Bargmann, Mien-Chie Hung & Robert A. Weinberg
Cell, Volume 45, Issue 5, p649–657, 6 June 1986
This study characterized for the first time tumor associated, activating single point mutations in the transmembrane domain of the neu oncogene.

Identification of a mammalian protein that binds specifically to DNA containing methylated CpGs
Richard R. Meehan, Joe D. Lewis, Stewart McKay, Elke L. Kleiner, Adrian P. Bird
Cell, Volume 58, Issue 3, p499–507, 11 August 1989
Meehan et al. discovered a mammalian methyl-CpG binding protein with differential expression in normal versus cancer cells.

The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
Anne J. Ridley, Alan Hall
Cell, Volume 70, Issue 3, p389–399, 7 August 1992
Results in this paper uncover the Rho-GTPase activity as regulator of focal adhesion- and stress-fiber formation, both elementary to cellular migration and cancer cell invasion.

Interleukin-10-deficient mice develop chronic enterocolitis
Ralf Kühn, Jürgen Löhler, Donna Rennick, Klaus Rajewsky, Werner Müller
Cell, Volume 75, Issue 2, p263–274, 22 October 1993
The first genetic abrogation of interleukin-10 reveals specific immuno-modulatory roles in the colonic epithelium in-vivo.

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Rosalind C. Lee, Rhonda L. Feinbaum, Victor Ambros
Cell, Volume 75, Issue 5, 3 December 1993, Pages 843–854
Report on the discovery of lin-4 as new regulator of translation that encodes a short, antisense mRNA-transcript recognizing complementary sequences in the 3’UTR of target loci.

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB
Vito J. Palombella, Oliver J. Rando, Alfred L. Goldberg, Tom Maniatis
Cell, Volume 78, Issue 5, 9 September 1994, Pages 773–785
First evidence for the ubiquitin-proteasome system to contribute to Nf-kB precursor processing and TNFalpha-signaling.

22 genes from chromosome 17q21: cloning, sequencing, and characterization of mutations in breast cancer families and tumors
Lori S. Friedman, Elizabeth A. Ostermeyer, Eric D. Lynch, Piri Welcsh, Csilla I. Szabo, Jose E. Meza, Lee A. Anderson, Patrick Dowd, Ming K. Lee, Sarah E. Rowell, Jay Ellison, Jeff Boyd, Mary-Claire King
Genomics Volume 25, Issue 1 , 1 January 1995, Pages 256–263
One of the seminal studies that eventually led to the discovery of BRCA-1gene mutations, revealing that inherited alleles are causally linked to human cancer.

Toward a cDNA Map of the Human Genome
Julie R. Korenberg, Xiao-Ning Chen, Mark D. Adams, Craig J. Venter
GenomicsVolume 29, Issue 2, September 1995, Pages 364–370
Technical advances described in this study enabled rapid definition of a high-resolution map of the transcribed human genome and mapping of disease-causing mutations, respectively.

The TAFII250 Subunit of TFIID Has Histone Acetyltransferase Activity
Craig A Mizzen, Xiang-Jiao Yang, Tetsuro Kokubo, James E Brownell, Andrew J Bannister, Tom Owen-Hughes, Jerry Workman, Lian Wang, Shelley L Berger, Tony Kouzarides, Yoshihiro Nakatani, C. David Allis
Cell, Volume 87, Issue 7, 27 December 1996, Pages 1261–1270
The discovery of an enzymatic activity that grants transcription factors access to literally silent/repressed parts of an animals genetic information.

Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function
Osamu Adachi, Taro Kawai, Kiyoshi Takeda, Makoto Matsumoto, Hiroko Tsutsui, Masafumi Sakagami, Kenji Nakanishi, Shizuo Akira
Immunity Volume 9, Issue 1, 1 July 1998, Pages 143–150
Discovery of MyD88 as integrator and molecular scaffold in both IL-1 and IL-18 mediated signaling.

Malignant effusions and immunogenic tumour-derived exosomes
Fabrice Andre, Noel EC Schartz, Mojgan Movassagh, Caroline Flament, Patricia Pautier, Philippe Morice, Christophe Pomel, Catherine Lhomme, Bernard Escudier, Thierry Le Chevalier, Thomas Tursz, Sebastian Amigorena, Graca Raposo, Eric Angevin, Laurence Zitvogel
The Lancet Volume 360, Issue 9329, 27 July 2002, Pages 295–305
An intriguing report on “membrane vesicles” (also called tumor-derived exosomes), which contain tumor-antigens for cross-presentation to cytotoxic T-lymphocytes.

Genomics of microRNA
V. Narry Kim, Jin-Wu Nam
Trends in Genetics Volume 22, Issue 3, March 2006, Pages 165–173
An expert summary on microRNAs in general and mechanistic discoveries regarding their biogenesis in particular.

Rare De Novo and Transmitted Copy-Number Variation in Autistic Spectrum Disorders
Dan Levy, Michael Ronemus, Boris Yamrom, Yoon-ha Lee, Anthony Leotta, Jude Kendall, Steven Marks, B. Lakshmi, Deepa Pai, Kenny Ye, Andreas Buja, Abba Krieger, Seungtai Yoon, Jennifer Troge, Linda Rodgers, Ivan Iossifov, Michael Wigler
Neuron Volume 70, Issue 5 , 9 June 2011, Pages 886–897
Systematic and comparative genomics on families affected by Autism to discover hundreds of disease-associated loci and points of their functional convergence. The paper offers unprecedented new insights into the underlying networks of a multifactorial disease .

FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism
Jennifer C. Darnell, Sarah J. Van Driesche, Chaolin Zhang, Ka Ying Sharon Hung, Aldo Mele, Claire E. Fraser, Elizabeth F. Stone, Cynthia Chen, John J. Fak, Sung Wook Chi, Donny D. Licatalosi, Joel D. Richter, Robert B. Darnell
Cell, Volume 146, Issue 2, 22 July 2011, Pages 247–261
Mutations in FMRP are causally linked to the fragile X syndrome and autistic features.  The discovery of pre- and postsynaptic protein-transcripts as FMRP-targets suggests ribosome stalling as disease mechanism and reveals very valuable targets for future therapeutic interventions.

Blessings in disguise: biological benefits of prion-like mechanisms
Gregory A. Newby, Susan Lindquist
Trends in Cell Biology, Volume 23, Issue 6, June 2013, Pages 251–259
A state of the art review on protein folding/self-templating conformational changes both in physiology and disease, that integrates the role of governing chaperones.

Repurposing CRISPR as an RNA-Guided Platform for Sequence-Specific Control of Gene Expression
Lei S. Qi, Matthew H. Larson, Luke A. Gilbert, Jennifer A. Doudna, Jonathan S. Weissman, Adam P. Arkin, Wendell A. Lim
Cell, Volume 152, Issue 5, 28 February 2013, Pages 1173–1183
Landmark paper on the functional deployment of a bacterial endonuclease for genetic engineering. 


Synthesis and hydrothermal stability of a disordered mesoporous molecular sieve
Ryong Ryoo, J.M. Kim, C.H. Shin, J.Y. Lee
Studies in Surface Science and Catalysis,Volume 105, 1997, Pages 45–52

Topological construction of mesoporous materials
Dongyuan Zhao, Yang Peidong, Huo Qisheng, Chmelka Bradley F, Stucky Galen D
Current Opinion in Solid State and Materials Science, Volume 3, Issue 1, February 1998, Pages 111–121

Nucleation, growth and form of mesoporous silica: role of defects and a language of shape
Geoffrey A. Ozin, Charles T. Kresge, Hong Yang
Studies in Surface Science and Catalysis,Volume 117, 1998, Pages 119–127

A novel synthesis of functional dithioesters, dithiocarbamates, xanthates and trithiocarbonates
San H. Thang, Y.K. Chong, Roshan T.A. Mayadunne, Graeme Moad, Ezio Rizzardo
Tetrahedron Letters,Volume 40, Issue 12, 19 March 1999, Pages 2435–2438

The `lightning' gold nanorods: fluorescence enhancement of over a million compared to the gold metal
Mona B. Mohamed, Victor Volkov, Stephan Link, Mostafa A. El-Sayed
Chemical Physics Letters,Volume 317, Issue 6, 11 February 2000, Pages 517–523

Dye-sensitized solar cells
Michael Grätzel
Journal of Photochemistry and Photobiology C: Photochemistry Reviews,Volume 4, Issue 2, 31 October 2003, Pages 145–153

Functionalisation of nanoparticles for biomedical applications
Nguyen T.K. Thanh, Luke A.W. Green
Nano Today, Volume 5, Issue 3, June 2010, Pages 213–230

Chemical biology on the genome
Shankar Balasubramanian
Bioorganic & Medicinal Chemistry,Volume 22, Issue 16, 15 August 2014, Pages 4356–4370


Van Hove scenario for cuprate superconductivity
D.M. Newns, H.R. Krishnamurthy, P.C. Pattnaik, C.C. Tsuei, C.C. Chi, C.L. Kane
Physica B: Condensed Matter,Volumes 186–188, 2 May 1993, Pages 801–807

Electronic phenomena in the conducting phases of orientationally disordered fullerides
E.J. Mele, S.C. Erwin, M.S. Deshpande
Synthetic Metals,Volume 65, Issues 2–3, August 1994, Pages 255–261

Microscopic origin of the Bekenstein-Hawking entropy
Andrew Strominger, Cumrun Vafa
Physics Letters B, Volume 379, Issues 1–4, 27 June 1996, Pages 99–104

On the role of classical and quantum notions in channeling and the development of fast positrons as a solid state probe of valence electron and spin densities
Lene Vestergaard Hau, J.A. Golovchenko, R. Haakenaasen, A.W. Hunt, J.P. Peng, P. Asoka-Kumar, K.G. Lynn, M. Weinert, J.C. Palathingal
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms,
Volume 119, Issues 1–2, 2 October 1996, Pages 30–41

Colossal magnetoresistive manganites
Y Tokura, Y Tomioka
Journal of Magnetism and Magnetic Materials,Volume 200, Issues 1–3, October 1999, Pages 1–23

Size-driven phase transition in stress-induced ferroelectric thin films
Jian Zhang, Zhen Yin, Ming-Sheng Zhang, James F. Scott
Solid State Communications,Volume 118, Issue 5, 26 April 2001, Pages 241–246

Method for determination of |Ue3| in neutrino oscillation appearance experiments
Takaaki Kajita, Hisakazu Minakata, Hiroshi Nunokawa
Physics Letters B,Volume 528, Issues 3–4, 7 March 2002, Pages 245–252

In situ electrical characterization of DH4T field-effect transistors
T. Muck, V. Wagner, U. Bass, M. Leufgen, J. Geurts, L.W. Molenkamp
Synthetic Metals,Volume 146, Issue 3, 3 November 2004, Pages 317–320

Nanowire photonics
Peter J. Pauzauskie, Peidong Yang
Materials Today, Volume 9, Issue 10, October 2006, Pages 36–45

Elsevier Connect Contributor

Thomas Schwarz-Romond, PhD, MBADr. Thomas Schwarz-Romond serves as Executive Publisher - Journals in Elsevier’s Berlin office. During his PhD and postdoctoral research, Thomas investigated the molecular and structural mechanisms of Wnt-signaling at the Max Delbrück Center for Molecular Medicine (MDC-Berlin) and the Medical Research Council Laboratory of Molecular Biology (MRC-LMB Cambridge). From 2006 to 2015, he worked as Scientific Editor for The EMBO Journal. He acquired managerial skills during an MBA leadership program and joined Elsevier in April 2015.

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