Computer Aided Chemical Engineering is a book series which publishes theme volumes and conference proceedings in the application of computing and systems technology to chemical engineering problems. Several major areas are represented in the series, including modeling, numerical analysis and simulation; mathematical programming(optimization); cyberinfrastructure, informatics and intelligent systems; process and product synthesis/design; process dynamics, control and monitoring; abnormal events management and process safety; plant operations, integration, planning/scheduling and supply chain; enterprise-wide management andtechnology-driven policy making and domain applications (molecular, biological, pharmaceutical, food, energy, and environmental systems engineering). For information about the series or to submit a proposal, please contact the Series Editors or the Acquisitions Editor, Susan Dennis at firstname.lastname@example.org.
Most recent volume
Quantitative Systems Pharmacology: Models and Model-Based Systems with Applications, Volume 42 describes and models at different scales the following topics: methods for diagnosis; administration and release of therapeutics; distribution metabolism and excretion of drugs; compartmental pharmacokinetics; physiologically-based pharmacokinetics; pharmacodynamics; identifiability of models; numerical methods for models identification; design of experiments; in vitro and in vivo models; allometric equations for scale-up from animals to humans; drug transport phenomena and methods; nanoparticles contribution; tumor PK and PD; system based approaches to drug treatments; model-based individualization of treatments; model predictive control of surgeries and treatments.
The pharma community is progressively acknowledging that a quantitative and systematic approach to drug administration, release, pharmacokinetics and pharmacodynamics is highly recommended to understand the mechanisms and effects of drugs. The book addresses the above questions with a quantitative approach to problem solving typical of engineers. The targeted contribution of a few medical doctors, pharmacists, biologists, and chemists enlarges the descriptive horizon and allows gathering the key elements necessary to model a complex machine like the human body from a number of perspectives and multiple scales.