1-minute animation: What is a hematopoietic stem cell?
HSC transplants are used in the treatment of cancers and other immune system disorders
By Ben Paylor, PhD, and Mike Long, PhD Posted on 27 May 2015
Hematopoietic stem cells (HSCs) are the type of stem cell that give rise to all the other blood cells. They are located in the bone marrow, which is contained in the core of most bones and is the site where new blood cells come from. HSCs are able to give rise to both myeloid (monocytes and macrophages, neutrophils, basophils, eosinophils, erythrocytes, megakaryocytes/platelets, dendritic cells), and lymphoid cells (T-cells, B-cells, NK-cells). The study of HSCs over the past 50 years have provided us with a much clearer understanding of how the blood system works. More recent advances have resulted in the use of HSC transplants in the treatment of cancers and other immune system disorders
StemCellShorts are narrated by experts in various aspects of stem cell research who are based in Canada. This one is narrated by Dr. Connie J. Eaves, Professor of Medical Genetics at the University of British Columbia in Vancouver.
StemCellShorts are the brainchild of Dr. Ben Paylor, Visiting Friedman Scholar at Stanford University, and Dr. Mike Long, a post-doctoral fellow at the University of Toronto.
The latest videos are jointly funded by the Canadian Stem Cell Network and Canadian Stem Cell Foundation. They are produced at the Vancouver-based animation studio InfoShots (@InfoShots), with award-winning animator David Murawsky and Emmy-nominated composer James Wallace creating the animations and music.
Recently, StemCellShorts received Honorable Mention in the Video category of the National Science Foundation's Visualization of Science competition. The videos were selected out of 227 entries submitted from 17 countries and were bested only by a video submitted by a team from NASA.
Elsevier Connect Contributors
Dr. Ben Paylor (@BenPaylor) is Visiting Friedman Scholar at the Stanford Center for Biomedical Ethics, where he is investigating the ability of new media (e.g., animation) to better educate patients involved in clinical trials, with a focus on those involving stem cells. He is very interested in the field of science communication and policy. He is the co-founder and director of InfoShots and writer and director of several award-winning science films.
In January, he completed his a PhD in the Experimental Medicine program of the University of British Columbia. His research focused on understanding the role of tissue-resident mesenchymal progenitors in repair processes of the heart.
Outside of science, he is an avid pianist and tennis player.
Dr. Mike Long earned his PhD in the Department of Medical Genetics at the University of British Columbia, where he was also involved in the creation of several start-up companies, including the animation studio InfoShots and the iOS development company Watermelon App Works Inc.
As a postdoctoral fellow at the University of Toronto, he is currently focused on the identification of ligands for orphan nuclear receptors and remains involved in a number science communication and education projects.