Series: Advances in Genome Biology

The remarkable proliferation of new techniques and the diversification of existing ones have resulted in explosive growth within various branches of cell biology. Consequently, cell biology and molecular genetics have become inseparable disciplines. Suffice to say molecular biology is a combination of both of these contemporary branches. The molecular approach has penetrated every traditional field of biological sciences, including medicine. The foundation of many fundamental discoveries has been based upon studying the cell at the subcellular level. For several decades, extensive studies on prokaryotes have provided an understanding of the fine structure of genes. However, who could have ever imagined, even a decade ago, that eukaryotic genes could be spliced, cloned and even re-designed. Recent recombinant DNA technology has opened new vistas toward understanding the linear order of genes on eukaryotic chromosomes; an idea that was once inconceivable. The main purpose of the series, Advances in Genome Biology, is to keep abreast of the latest developments in the field and to further nurture and promote the linkage between newcomers and existing researchers. Each volume shall address a specific theme, depicting current progress and future investigative directions pertaining to genome research. Furthermore, this inaugural issue has attempted to elucidate the importance of the various molecular techniques currently being applied in an effort towards deciphering the genome. A complete account of the numerous available techniques, within the scope of single volume format, would be a herculean task. Therefore, I have chosen only the topics, which will have the greatest interest to the majority of investigators. In fact, the progress in molecular techniques has advances so rapidly that each method could easily occupy a single volume.
Genes and Genomes

Most recent volume

Volume 5. Genes and Genomes

Published: 3rd June 1998 Editors: R.S. Verma
The laws of inheritance were considered quite superficial until 1903, when the chromosome theory of heredity was established by Sutton and Boveri. The discovery of the double helix and the genetic code led to our understanding of gene structure and function. For the past quarter of a century, remarkable progress has been made in the characterization of the human genome in order to search for coherent views of genes. The unit of inheritance termed factor or gene, once upon a time thought to be a trivial an imaginary entity, is now perceived clearly as the precise unit of inheritance that has continually deluged us with amazement by its complex identity and behaviour, sometimes bypassing the university of Mendel's law.
The aim of the fifth volume, entitled Genes and Genomes, is to cover the topics ranging from the structure of DNA itself to the structure of the complete genome, along with everything in between, encompassing 12 chapters. These chapters relate much of the information accumulated on the role of DNA in the organization of genes and genomes per se. Several distinguished scientists, all pre-eminent authorities in each field to share their expertise. Obviously, since the historical report on the double helix configuration in 1953, voluminous reports on the meteoric advances in genetics have been accumulated, and to cover every account in a single volume format would be a Herculean task. Therefore, only a few topics are chosen, which are of great interest to molecular geneticists. This volume is intended for advanced graduate students who would wish to keep abreast with the most recent trends in genome biology.

Additional volumes

Volume 4. Genetics of Sex Determination

Published: 23rd April 1996 Editors: R.S. Verma

Volume 3. Genetics of Human Neoplasia, Part A

Published: 25th September 1995 Editors: R.S. Verma

Volume 2. Morbid Anatomy of the Genome

Published: 1st February 1994 Editors: R.S. Verma

Volume 1. Unfolding the Genome

Published: 8th June 1992 Editors: R.S. Verma