High-recall, high-precision capture of adverse drug reactions

A key component of diverse and increasingly complex pharmacovigilance regulatory requirements is systematic screening of biomedical literature for adverse drug reactions (ADRs). Capturing all potential and unanticipated health risks for a drug from the international biomedical literature also allows pharmaceutical companies to proactively develop more effective drug safety strategies.

Adverse drug reactions - Embase | Elsevier solutions

How Embase helps
Easily track all published, peer-reviewed biomedical information on your products. Embase gives you access to the world's most comprehensive database of biomedical literature, including non-English content. The user-friendly interface also provides unique support for the creation of high-recall, high-precision search strings.

Embase helps users to:

  • Generate information search strategies that have high recall and precision
  • Track precise drug safety information across the literature

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  • Perform risk–benefit assessments and create risk mitigation strategies
  • Comply with regulations on drug safety and pharmacovigilance

How Embase works

Embase is designed to deliver answers that empower PV teams to make risk–benefit assessments, meet pharmacovigilance reporting deadlines and improve drug safety. It provides:

  • Comprehensive and up-to-date drug safety information, with over 30 million records from more than 8,000 journals and 5,500 conferences
  • (Coming soon) The French Local Language Module to identify all mentions of adverse events in selected French-language literature as part of the global process
  • Direct linking of drugs, diseases and devices to associated events mentioned in the article, enabling more precise retrieval of adverse event information
  • PV Wizard to facilitate vastly quicker creation of the complex search strings needed for high-recall, high-precision searches focused on adverse events
  • Search automation and alerting features to ensure that all newly published information is quickly captured and no adverse event is missed

Download the Embase Fact Sheet (PDF, 577.0 KB)

How PV Wizard works

This new infographic shows how PV Wizard vastly reduces the time needed to generate high-recall, high-precision searches for adverse events.

Introducing the PV Wizard search form

Example applications of Embase

The key to more efficient risk-benefit analysis - Pharma and Life Sciences | Elsevier

What is the key to more efficient risk–benefit analysis?

A strong drug safety strategy with efficient risk–benefit analysis is a commitment to patient safety and a healthy drug life cycle. This new white paper assesses the five steps to follow in building an efficient, accurate and compliant strategy for capturing and reviewing adverse event information from the biomedical literature.

See the white paper

An application note for Embase | Elsevier solutions

Best practices for building PV search strategies

This new application note gives a step-by-step example of building a search for adverse drug events using Embase’s PV Wizard. The method described can be applied to any pharmacovigilance-focused search of the biomedical literature.

Read the application note

Facilitating government decisions in healthcare - Embase | Elsevier stories

Embase supports government decisions in healthcare

The choice of which drugs and treatments are eligible for government reimbursement depends on accurate health technology assessments. This interview with Dr. George R. Khachatryan explains the role of biomedical literature in these crucial decisions.

See the solution story


Ideas and insights for industry professionals

Balancing in-house and outsourced monitoring

Balanced handling of pharmacovigilance challenges - R&D Solutions | Elsevier

Combining outsourced literature management with an in-house solution can help companies overcome search challenges by improving oversight, increasing efficiency and providing greater flexibility in managing workload.

Read the white paper

Improving the accuracy of signal detection

Signal detection in spontaneous reporting can be challenging - R&D Solutions | Elsevier

Pharmacovigilance ensures the correct use of a drug, safeguarding it as a meaningful treatment option. But working with spontaneous adverse event reporting systems poses challenges. Find out how to overcome them.

Read the white paper


Learn more about Elsevier's R&D Solutions for Pharmacovigilance

Thousands of pharmacovigilance and drug safety teams at pharmaceutical companies rely on Elsevier’s R&D Solutions and services. We have focused on providing comprehensive coverage of drug safety data sources and alleviating challenges with pharmacovigilance processes. In addition to Embase, drug safety teams worldwide benefit from the support of these solutions and services.

QUOSA PV

Promote efficiency and organizational compliance. QUOSA PV centralizes the discovery of adverse event information from multiple sources and automates information monitoring and triage in a scalable, GxP-compliant environment.

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Professional Services

Let informatics and analytics experts support your drug safety goals. Our Professional Services team can streamline adverse event and safety signal detection by validating search strategies and implementing solutions for literature triage and review.

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PharmaPendium

Make more informed decisions on drug safety and efficacy, risk, and study design. PharmaPendium delivers comparative drug interaction data and facilitates searches of FDA and EMA drug approval document sources, including FAERS.

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