Participant Profile: Myelo Therapeutics - The Hive

Participant profile: Myelo Therapeutics

Developing innovative treatments
that target areas of high unmet need

Participant Profile: Myelo Therapeutics logo - The Hive

Myelo Therapeutics is a pharmaceutical company based in Germany that develops innovative treatments in areas of high unmet medical needs. The company’s lead compound, Myelo001, is an orally applied small molecule, currently being investigated in a phase IIa clinical trial.


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Reducing the occurrence of chemotherapy-induced Neutropenia with Myelo001

Cytotoxic chemotherapy frequently suppresses the hematopoietic system, impairing host protective mechanisms. Chemotherapy-induced Neutropenia (CIN), the most serious hematologic toxicity, is associated with the risk of life-threatening infections.

As a consequence of such an infection it can become necessary to reduce dosage of or delay chemotherapy, which may compromise treatment outcomes. Myelo001 reduces the occurrence of CIN. In addition to its protective properties, Myelo001 is effective in preventing a broad range of viral infections, an important added benefit for immunosuppressed patients.

Myelo001 is the first new therapy option for chemotherapy-induced neutropenia (CIN) in over 20 years. Preclinical and first clinical studies confirmed good safety and efficacy in CIN prophylaxis. However, the molecular mode of action and binding site at the target molecule is not yet fully elucidated. This is the primary objective of Myelo Therapeutics’ non-clinical research program.

Broad expertise put to a great purpose

Myelo’s researchers have experience ranging from academia to Big Pharma R&D, covering areas such as neurology, ophthalmology, hematology, and immunology, and they now bring their knowledge and abilities to advance Myelo’s mission to tackle unmet needs.

Meet the team

Dirk Pleimes
  Managing Director and Chief Medical Officer - The Hive | Elsevier

Dirk Pleimes
Managing Director and Chief Medical Officer

After several years in big pharma R&D in Neurology, Ophthalmology and Hematology, Dirk co-founded start-up Myelo Therapeutics, where he leads the R&D team to develop novel molecules from preclinical to clinical phase 3 in areas of high unmet medical needs.

Participation in The Hive enables Myelo to conduct an optimized search of relevant data via software assisted literature research. This ability to view our research in context of the knowledge and expertise of the global scientific community will make our work more efficient.

Dr. Corinna Asang
  Science and Clinical Trial Manager - The Hive | Elsevier

Dr. Corinna Asang
Science and Clinical Trial Manager

After her PhD in HIV-1 RNA splicing followed by several years of postdoctoral research in the field of immunology and pediatric cancer at the University Hospital Düsseldorf, Corinna joined Myelo Therapeutics to develop the company’s antiviral research area.

Accessing the immune response’s molecular interactions and downstream pathways more rapidly, significantly optimizes. Together with additional data available from the research community, the Hive program speeds up the transition from experimental data to novel hypothesis for antiviral mechanisms.

Patrik Brehm
  Preclinical Research Manager - The Hive | Elsevier

Patrik Brehm
Preclinical Research Manager

Patrik joined Myelo Therapeutics to direct the bulk of pre- and non-clinical research on Myelo001 afterstudying biochemistry at LMU in Munich and earning his master’s thesis on the stem cell-like seam cells in C. elegans at the Imperial College London.

Being part of the Hive provides us with easier access to relevant information via Elsevier’s software assisted literature research. Moreover, the ability to quickly connect the latest data with available literature knowledge helps us to streamline research analysis, which in turn speeds up our workflow, enabling better future research decisions and cost savings.

The Hive: Supporting Myelo Therapeutics’ efforts to move their R&D projects forward

Dirk Pleimes, Managing Director and Chief Medical Officer, is able to get an overview and optimized search of relevant data due to software assisted literature research. Screening a broad range of indication and putting findings from Myelo’s research in context of the vast knowledge available from the global scientific community is considerably facilitated with The Hive and renders his work more efficient.

Patrik Brehm, Preclinical Research Manager, also appreciates being able to get an easier overview due to software assisted literature research. Moreover, the possibilities of streamlining research analysis, by being able to quickly connect latest data with available literature knowledge, will speed up Patrik’s workflow, result in better future research decisions, and additionally save costs for Myelo Therapeutics. Furthermore, the exposure of Myelo Therapeutics through the Hive program will enable easier connections with potential research collaborators and allow Patrik to grow his network of scientific experts.

Dr. Corinna Asang, Science and Clinical Trial Manager, can quickly identify matching collaborators and establish creative partnerships keen on incubating scientific ideas. Accessing immune response’s molecular interactions and downstream pathways more rapidly optimizes her work significantly. Together with additional data available from the research community, this program speeds up the transition from experimental data to novel hypothesis for antiviral mechanisms.

Blog: Pharma R&D Today

Working to Uncover the Mode of Action

Posted on March 2nd, 2017 by Patrik Brehm in Pharma R&D
The New Year has brought some new talent into the Myelo Therapeutics team. In January we welcomed Susann, our new postdoctoral researcher. We’re excited to have someone with her experience, which includes studying molecular biology in Dresden and Heidelberg, Continue reading Working to Uncover the Mode of Action »

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