Identify emerging trends in pancreatic cancer literature
Pancreatic cancer is the third leading cause of cancer death in the United States. Primary ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer. As an indication of the difficulty in catching the disease at an early stage, over half of cases are identified after the cancer has metastasized. New and innovative therapies are needed to address this unmet medical need.
Key findings of the report include:
- The upregulation of two long non-coding RNAs (lncRNA) XIST and linc00511 in pancreatic tissue were correlated with poor patient outcomes.
- Higher levels of the methyl transferase METTL3 and lower levels of the demethylase ALKBH5 resulted in higher levels of methylated m6A RNA and poorer prognosis.
- The induction of ferroptosis, a type of regulated cell death, is being looked at as a potential treatment for pancreatic cancer.
- New insights into the mechanisms of pancreatic cancer’s ‘immune evasion’ are being reported.
- There is increasing evidence that propofol has biological effects that may alter the progression of pancreatic cancer.
Staying up to date with emerging trends on a scientific topic is key to being at the forefront of scientific research and opportunity. This is especially true in the pharmaceutical industry, where decisions made today could have far reaching consequences over the span of a drug discovery program.
Text mining is one way to analyze emerging trends in research literature. Learn how Elsevier’s text mining tool can be used to identify emerging trends in pancreatic cancer literature using trending taxonomy terms, regression parameters, and additional normalization methods.