Therapeutic Effects of Phenothiazine Compounds


Application Note

Identifying a Polypharmacological Profile for Phenothiazines

Therapeutic Effects of Phenothiazine Compounds

Extracting data from the Heatmap enables the exploration of the therapeutic effect of phenothiazine compounds with a pX value higher than 5.0 (Figure 8). Phenothiazine scaffolds could have potential as cytotoxic and antineoplastic agents.

Analysis of phenothiazine structures and associated biological targets

Conclusion

This study demonstrates that in silico profiling using Reaxys Medicinal Chemistry is an efficient and rapid method to assess the polypharmacology of compounds, as shown here with the example of phenothiazine compounds. This method could be used to investigate the mechanism of action or act as a starting point for research into new indications for a compound.


Essential Drug Discovery Solution

Reaxys Medicinal Chemistry empowers hit identification and lead optimization with normalized compound–target affinity data and comprehensive pharmacokinetic, efficacy, toxicity, safety and metabolic profiles.

Learn more