From Molecule to Market in Less Time

A CRO managed customer needs while minimizing R&D costs with Reaxys, boosting productivity and enhancing predictability, which allowed for greater margins and shorter lead times.

From Molecule to Market in Less Time  - Alpha Moment

Challenge

Quickly Define Possible Solutions and Cost Structure That Works
A director of business development at a contract research organization wanted to minimize his lab’s R&D timeline for a new project. His goal was to drive revenue by quickly identifying potential solutions and determining the most profitable way to charge the client.

Our chemists were asked to develop a series of molecules that could be used to do coupling reactions with ring systems, explains Peter Voigt, the director. We needed to find the best reaction pathways for generating the molecule, and then decide on a cost structure that would work for everyone.

Solution

Immediate Visibility Into the Most Promising Molecules
The lab team sifted through a large number of different chemistries using Reaxys, and narrowed its focus on the molecules that they felt had the highest probability of success. We placed a core reaction that used two types of reagents and a functional ring group structure to find how many different chemistries were possible, explains Voigt. Reaxys gave us 200-300 examples right away, and then we settled on 30-40 unique molecules based on our literature search. With detailed results at his disposal, Voigt reasoned that because the client was looking for 25 potential molecules, it would be best to bill the project as a per-molecule deliverable.


With Reaxys, I knew for sure that our chemists could develop between 25 to 35 unique molecules. Before, I would have to make an educated guess as to how many we could produce. Peter Voigt, Director, Business Development, Contract Research Organization


Impact

Going From Molecule to Market In Less Time Equals Increased Cash Flow
The information provided by Reaxys substantially increased chemist productivity, and even enabled the team to work on two to three reactions for different clients at the same time. With Reaxys, I knew for sure that our chemists could develop between 25 to 35 unique molecules. Before, I would have to make an educated guess as to how many we could produce, adds Voigt. Our clients want to see that they are not just paying for extended research time, but that they are getting the actual development of compounds that they can then test and evaluate in their own laboratories, and also use this information to protect their intellectual property.

All told, the chemists on the team were able to skip over lengthy beginning steps and jump right into the action, increasing the company’s billable rate per chemist and also its cash flow.



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