Elsevier MDL Sets New Standard For Chemistry Data Cartridge

Single cartridge accelerates R&D by providing unrivalled chemical and stereochemical representation and unsurpassed performance in searching molecule and reaction databases

N RAMON, CA – December 20, 2006 – Elsevier MDL has released the MDL® Direct 6.0 chemistry data cartridge enabling researchers to register, search and retrieve structures and reactions stored in large databases entirely in the Oracle® relational environment. Already used by more than 80 percent of life sciences organizations, the MDL Direct data cartridge is the database component of MDL® Isentris® 2.0 system, which sets a new standard in information access and the integration of content and workflow. With this latest release, Elsevier MDL also extends support to the Linux platform, thereby expanding the availability of MDL Direct data cartridge technology to a growing community of scientific researchers.

"MDL Direct 6.0 offers industry-leading chemistry capabilities and reaction searching performance, in addition to comprehensive integration with a full suite of workflow applications from a proven provider of cheminformatics solutions," said Dr. Trevor Heritage, Senior Vice President and Chief Scientific Officer of Elsevier MDL. "By providing a pure cartridge architecture that can be used in any data model and accessed from any SQL (Structured Query Language)-compliant application, MDL Direct offers both flexibility and solid functionality for handling chemical information in a modern, integrated database environment."

MDL Direct technology incorporates Elsevier MDL’s premier chemistry searching capabilities including Rgroup, Sgroup, flexmatch, 2-D and 3-D exact and molecule/reaction substructure searching; structure similarity, super-similarity and sub-similarity searching; reaction similarity searching; comprehensive registration; and searching of tetrahedral stereoisomers and non-tetrahedral stereoisomers.

New, improved indexing provides an impressive improvement in performance for scientists searching large reaction databases. MDL Direct is the only chemistry search engine that combines full reaction transformation searching, unsurpassed chemistry sophistication and proven performance on databases with over five million reactions and at least 20 million structures.

As the database tier of the MDL® Isentris® system, MDL Direct accelerates structure and reaction searching for the Isentris system and for related applications including MDL® Registration (for building compound registries) and MDL® Notebook (for managing laboratory workflows and data entry in an e-R&D environment).

To protect customer investments in legacy systems and ensure a smooth transition to the new technology, straightforward conversion tools will simplify upgrading to MDL Direct 6.0. Existing MDL® ISIS customers or those with the previous version of MDL Direct will migrate to the new environment at their own pace in a step-wise, straightforward manner.

For more information about this powerful relational database tool for chemical structure and reaction searching, visit www.mdl.com.

About Elsevier
Elsevier is a global information analytics business that helps scientists and clinicians to find new answers, reshape human knowledge, and tackle the most urgent human crises. For 140 years, we have partnered with the research world to curate and verify scientific knowledge. Today, we’re committed to bringing that rigor to a new generation of platforms. Elsevier provides digital solutions and tools in the areas of strategic research management, R&D performance, clinical decision support, and professional education; including ScienceDirect, Scopus, SciVal, ClinicalKey and Sherpath. Elsevier publishes over 2,500 digitized journals, including The Lancet and Cell, 39,000 e-book titles and many iconic reference works, including Gray's Anatomy. Elsevier is part of RELX, a global provider of information-based analytics and decision tools for professional and business customers. www.elsevier.com

Media Contact
Jean Holt
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Elsevier MDL
Phone: (925) 543-5400