Efficient Lead Development

Reaxys: The Shortest Path to Chemistry Data for Early Drug Discovery, Lead Optimization and More

Validating lead candidates that will succeed in preclinical and clinical trials requires efficient access to relevant and accurate data on chemical reactions and bioactivity.

Thanks to powerful search options, expertly curated
databases and tools to support in silico profiling,
Reaxys and Reaxys Medicinal Chemistry provide
direct access to answers for critical decisions
in pharmaceutical R&D, particularly for
lead validation and optimization.

What Our Customers Say

The following customer interviews highlight how chemical data and bioactivity data from Reaxys and Reaxys Medicinal Chemistry provide a distinct advantage in the highly competitive world of pharmaceutical R&D and life sciences.

Pharmaceutical R&D - Dr. Anders Lohse

We very rarely have to go beyond Reaxys and read the source to find what we need.

Dr. Anders Lohse, Vice President of Project Management at NCK, discusses the role of high-quality data in his company’s research and how Reaxys supports the optimization of reactions and development of processes for the production of active pharmaceutical ingredients.

Click here to read the full customer interview (PDF, 796kb)

Pharmaceutical R&D – Dr. Fabio Tucci

Reaxys makes computational work easier because the chemical and bioactivity data are normalized. We don’t have to perform the normalization ourselves.

Dr. Fabio Tucci, co-founder and COO of Epigen Biosciences, discusses how he and his fellow researchers use chemical data from Reaxys to support their application of advanced hit-to-lead and lead optimization methods, such as in silico profiling.

Click here to read the full Elsevier case study (PDF, 1.2mb)

Pharmaceutical R&D – Dr. Gary Allred

Reaxys saves us considerable time. It makes it easier to model the synthesis of new leads and make decisions about which ones to pursue.

Dr. Gary Allred, co-founder, president and CEO of Synthonix, describes how his company uses data on chemical reactions and synthesis routes in the development of highly versatile chemical compounds.

Click here to read the full Elsevier case study (PDF, 670kb)

Pharmaceutical R&D - Dr. Bel Mekonnen

Reaxys and Reaxys Medicinal Chemistry] are really well suited to lead identification and validation. The medicinal chemistry data is really useful when we're scoping out the interactions between a target class and similar compounds to our leads.

Dr. Bel Mekonnen is the CEO of the start-up drug discovery organization Hager Biosciences, which is focused on the development of lead compounds for unmet medical needs. In this interview, he discusses how drug developer's data needs have changed, and how Reaxys fits their current requirements.

Click here to read the full customer interview (PDF, 450kb)

Pharmaceutical R&D - Mercachem

Our process research services focus on the development of efficient production processes for selected drug candidates. Reaxys helps our chemists to be more creative and efficient in the lab and thus provide a higher output to our clients.

Dr. Tommi Meulemans, project manager in Mercachem's Organic Synthesis group, is concerned with finding innovative, cost-effective and time-efficient ways to deliver on customer requests. Reaxys has the data to help his team develop optimal synthesis routes and maintain stringent quality control.

Click here to read the full customer interview (PDF, 606kb)

Pharmaceutical R&D - Ironwood

Reaxys can quickly lead you to a practical starting point. If you can't find the exact compound, you just search for similar sequences of reactions to get to the target compounds.

Takahashi Nakai, a medicinal chemist at Ironwood Pharmaceuticals, describes how Reaxys supports him with a multitude of tasks: SAR analyses, target identification, synthesis route planning and compound characterization.

Click here to read the full customer interview (PDF, 591kb)

Reaxys Fact Sheet

Reaxys provides powerful search options to give researchers total control of their search, ensuring only the most relevant answers to their chemistry questions.

Download the Reaxys Fact Sheet (PDF, 1.7mb)

Reaxys Medicinal Chemistry Fact Sheet

Reaxys Medicinal Chemistry empowers hit identification and lead optimization with normalized compound–target affinity data and comprehensive pharmacokinetic, efficacy, toxicity, safety and metabolic profiles.

Download the Reaxys Medicinal Chemistry Fact Sheet (PDF, 1.2mb)

Real Stories. Real Science. Real Time.

Visit the Hive to explore how biotech and pharma start-ups are using Elsevier R&D solutions to solve for early-stage drug discovery and development. Watch videos, read real-world case studies and learn how early innovation starts with rapid results and early access to research that is crucial to reducing the likelihood of costly late stage failures and mitigating risk.

Learn more about the Hive

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