Preclinical and clinical data for more informed and faster drug development decisions
Successful drug development requires anticipating safety and regulatory issues as early as possible. To preclude drug approval challenges, preclinical safety assessment and clinical development teams require tools that enable data-driven drug discovery and development.
How PharmaPendium helps
PharmaPendium provides comparative regulatory document-based evidence in a single translational database for better-informed risk-benefit analyses and drug candidate assessments. Users can leverage comparative information (drugs, drug classes, targets) to anticipate the best drug development strategy.
- Searchable FDA and EMA regulatory documents
- Searchable FDA Advisory Committee meeting reports
- Dedicated search functions for the FDA Adverse Event Reporting System (FAERS), including tools to reveal differences in adverse event reporting
- Extracted comparative data on pharmacokinetics, efficacy, safety and metabolizing enzymes and transporters
PharmaPendium helps users:
- Identify and assess potential drug–drug interactions to define risk mitigation strategies
- Improve the speed and success of regulatory submissions
- Validate the best animal model to use and predict how results translate to the clinic
- Make better-informed decisions on which drugs have the best potential to succeed in clinical development
- Avert potential safety and efficacy risks in clinical studies
The new approach to risk–benefit analyses
Proper prioritization of drug candidates requires accurate risk–benefit analyses. The right information means safer, more clinical focused trials and safer marketed drugs. PharmaPendium’s new DMPK Solution provides PK and ME&T data, FDA and EMA documents, and DDI risk calculation support to facilitate these critical assessments.
How PharmaPendium works
PharmaPendium provides Drug Safety and FAERs data, along with dedicated data modules that provide insights and information on the critical focused areas of drug development, drug safety, ADME and drug-drug interactions.
Download the PharmaPendium fact sheet (PDF, 0.604 MB)
Optimize drug candidate selection and mitigate the risk of sub-optimal clinical trial study designs with deeply enriched, comparative efficacy data extracted from FDA and EMA drug approval documents.
Download the efficacy fact sheet (PDF, 2.3 MB)
Drive successful regulatory approval strategies by analyzing drug candidates' pharmacokinetic properties within the context of the complete landscape of approved drugs.
Download the Pharmacokinetics Module Fact Sheet (PDF, 0.464 MB)
PharmaPendium efficacy module for translational and clinical research
As clinical trials become more complex and costly, optimized study designs that take drug candidate efficacy and efficacy precedents into account are an essential part of risk mitigation. Learn how the PharmaPendium Efficacy Module can help you mitigate the risk of efficacy-related clinical failure.
Read more about PharmaPendium's Efficacy Module
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Learn more about Elsevier's R&D Solutions for Drug Discovery & Development
Realize the potential of data-driven drug discovery and development with solutions that help you increase research efficiency and ensure a thriving R&D pipeline.
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