Skip to main content

Unfortunately we don't fully support your browser. If you have the option to, please upgrade to a newer version or use Mozilla Firefox, Microsoft Edge, Google Chrome, or Safari 14 or newer. If you are unable to, and need support, please send us your feedback.

Publish with us
Skeletal Muscle



Read more

Quick Facts

The perimysium is the connective tissue investing a fascicle of skeletal muscle fibers (Dorland, 2011).

Complete Anatomy
The world's most advanced 3D anatomy platform
Try it for Free


The perimysium is a tough and relatively thick layer of connective tissue that consists primarily of type I and type III collagen fibers. Some of the collagen fibers run alongside the underlying muscle fibers, while others are arranged in a “crisscross” pattern around the muscle fascicle.

Key Features/Anatomical Relations

The perimysium divides the skeletal muscle into various compartments/sections called fascicles, which contain bundles of muscle fibers. The three collagenous sheaths, the epimysium, perimysium, and endomysium, unite and fuse where the muscles connect to adjoining structures such as tendons. Underlying the perimysium proper is a network of loose irregularly arranged connective tissue which is also attached to the endomysium (MacIntosh, Gardiner and McComas, 2006).


The perimysium is composed of collagen and elastin fibers, which contributes to the resistance of a muscle to tensile forces. The perimysium also provides a path for nerves and blood vessels, which innervate and supply the blood flow to the fascicles containing the muscle fibers (Martini et al., 2017).

List of Clinical Correlates


—Mysium damage

—Connective tissue disease


Dorland, W. (2011) Dorland's Illustrated Medical Dictionary. 32nd edn. Philadelphia, USA: Elsevier Saunders.

MacIntosh, B. R., Gardiner, P. F. and McComas, A. J. (2006) Skeletal Muscle: Form and Function. Human Kinetics.

Martini, F. H., Nath, J. L. and Bartholomew, E. F. (2017) Fundamentals of Anatomy & Physiology. Pearson Education.

Complete Anatomy

The world's most advanced 3D anatomy platform

Complete Anatomy