Skip to main content

Unfortunately we don't fully support your browser. If you have the option to, please upgrade to a newer version or use Mozilla Firefox, Microsoft Edge, Google Chrome, or Safari 14 or newer. If you are unable to, and need support, please send us your feedback.

Publish with us
Skeletal Muscle



Read more

Quick Facts

The endomysium is the sheath of delicate reticular fibrils that surrounds each muscle fiber (Dorland, 2011).

Complete Anatomy
The world's most advanced 3D anatomy platform
Try it for Free


The endomysium is a delicate sheath of connective tissue which envelopes each individual skeletal muscle fiber, consisting primarily of type III and type IV collagen (Standring, 2016).

Key Features/Anatomical Relations

Endomysium surrounds the individual skeletal muscle fibers within the fascicles and forms their immediate internal environment. The three collagenous sheaths, the epimysium, perimysium, and endomysium unite and fuse where the muscles connect to adjoining structures such as tendons.


The endomysium is the site of metabolic exchange between blood and the skeletal muscle fiber, as it contains capillaries which supply the muscle fiber. As this layer is composed of collagen and elastin fibers, it contributes to the resistance of a muscle to tensile forces.

List of Clinical Correlates

—Myasthenia gravis

—Mysium damage

—Connective tissue disease


Dorland, W. (2011) Dorland's Illustrated Medical Dictionary. 32nd edn. Philadelphia, USA: Elsevier Saunders.

Standring, S. (2016) Gray's Anatomy: The Anatomical Basis of Clinical Practice. Gray's Anatomy Series 41 edn.: Elsevier Limited.

Complete Anatomy

The world's most advanced 3D anatomy platform

Complete Anatomy