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Primary Lymphoid Nodule
Lymphoid System

Primary Lymphoid Nodule

Nodulus lymphoideus primarius

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Quick Facts

A primary lymphoid nodule is a lymphoid nodule that has not been exposed to antigen and lacks a germinal center; upon activation of B lymphocytes it develops into a secondary lymphoid nodule (Dorland, 2011).

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Primary lymphoid nodules are small spherical clusters of B lymphocytes, or B cells, tightly packed together within the reticular meshwork of the cortex. In the primary nodule, the B cells can interact with follicular dendritic cells. When a B cell interacts with an antigenic-displaying follicular dendritic cells, it stimulates clonal expansion and rapid proliferation of the B cells. This activation results in the nodule becoming a secondary lymphoid nodule (Willard-Mack, 2006).

List of Clinical Correlates


—Hodgkin’s Lymphoma



Dorland, W. (2011) Dorland's Illustrated Medical Dictionary. 32nd edn. Philadelphia, USA: Elsevier Saunders.

Willard-Mack, C. L. (2006) 'Normal structure, function, and histology of lymph nodes', Toxicologic Pathology, 5(34), pp. 409-424.

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