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Skin (Prepuce; Right)

Skin (Prepuce; Right)


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The skin functions as a barrier against the external environment, such as harmful microbial organisms and damage from mechanical, chemical, thermal, and UV stimuli. The skin also performs an important endocrine function, such as Vitamin D formation and synthesis of cytokines and growth factors. The skin also plays a role in excretion, through the secretion of sweat and sebum. Also, the skin is important in maintaining homeostasis by controlling the body's temperature and water loss. The various sensory receptors inside the skin make it an important organ for receiving sensory information from the external environment.

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The skin is the largest organ in the human body accounting for almost 15% of its weight. It covers the entire external surface of the body and is continuous with the mucosae of the digestive, respiratory, and urogenital tracts. The thickness of the skin varies greatly from 1.5-5 mm, depending on its location (Standring, 2016).

The skin consists of three layers including the superficial epidermis, the dermis in the middle and the deep subcutaneous tissue.

- The epidermis is an epithelial tissue layer that undergoes constant renewal throughout life, mediated by a stem cell population within it. It mainly consists of keratinized stratified squamous epithelium.

- The dermis lies beneath the epidermis. It’s a dense connective tissue that provides strength to the skin through a diffuse interwoven orientation of collagen and elastic fibers throughout it. It’s in the dermis where the skin receives its neurovascular supplies. The dermis has two sublayers, namely a superficial papillary layer and a deeper reticular layer.

- The subcutaneous tissue is the deepest layer and is composed of a loose connective tissue with variable amounts of adipose cells interspersed (Ross and Pawlina, 2006).

There are two main types of skin:

- thick, hairless (glabrous) skin, which is found on the soles of feet, palms of the hands, and flexor surfaces of the digits;

- thin, hairy skin that covers the largest area of the body.


Nerves transmit sensory information from the skin to designated spinal nerves through its anterior and posterior rami. The defined area of skin corresponding to each nerve fiber is known as a dermatome. There are 3 trigeminal, 5 cervical, 12 thoracic, 5 lumbar, and 5 sacral spinal nerves supplying the dermatomes. Various models for the distribution of dermatomes, or dermatome maps, now exist. However, because different experimental procedures were used to establish these maps, significant variation exists throughout the literature (Keegan and Garrett, 1948, Foerster, 1933, Lee et al., 2008, Head et al., 1997). Generally, dermatome maps are inconsistent and there is significant overlap between adjacent spinal nerves. The commonly used Keegan and Garrett map is a widely accepted dermatome map and is portrayed in this model (Keegan and Garrett, 1948). Dermatome maps still remain a fundamental concept in human anatomy relevant to clinical practice, e.g., differential diagnosis of referred pain from visceral disease, to determine sensory limits of region anesthesia, determining the level of spinal cord injury, or insult caused by prolapsed intervertebral discs.

The S2 and S3 dermatomes cover the skin of the penis and scrotum, S3 and S4 dermatomes cover the perianal region, while S5 covers the skin adjacent to the anus.


Foerster, O. (1933) 'The Dermatomes in Man', Brain, 56(1), pp. 1-39.

Head, H., Campbell, A. W. and Kennedy, P. G. (1997) 'The pathology of Herpes Zoster and its bearing on sensory localisation', Rev Med Virol, 7(3), pp. 131-143.

Keegan, J. J. and Garrett, F. D. (1948) 'The Segmental Distribution of the Cutaneous Nerves in the Limbs of Man', The Anatomical Record, 102(4), pp. 409-437.

Lee, M. W., McPhee, R. W. and Stringer, M. D. (2008) 'An evidence-based approach to human dermatomes', Clin Anat, 21(5), pp. 363-73.

Ross, M. H. and Pawlina, W. (2006) Histology: A text and atlas. Lippincott Williams & Wilkins.

Standring, S. (2016) Gray's Anatomy: The Anatomical Basis of Clinical Practice. Gray's Anatomy Series 41 edn.: Elsevier Limited.

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Skin is a complex organ composed of two major layers—the epidermis and dermis—and a network of collagen, elastic fibers, blood vessels, and nerve endings.

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