Alzheimer’s disease research insights: impacts, trends, opportunities

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Alzheimer’s disease affects 45 million people worldwide, and research is now moving towards behavior for prevention and treatment.

The incidence of disease has plateaued, as has research: while research output for Alzheimer’s disease exceeded the growth seen for all research between 2008 and 2012, this subsequently slowed and has tracked average growth in global research output since 2013. Although the volume of research is not accelerating, the content is shifting. Since the 1990s, there has been a major focus on amyloid protein in Alzheimer’s disease research, but, more recently, behavioral topics such as learning, sleep and gait have emerged as a focus.

The United States produces by far the most output – almost double that of China, which is in second place. The focus on Alzheimer’s disease research is highest in high income countries, with Sweden, Italy and Spain at the top. This reflects the high priority this research has taken in countries where lifespan is longer and therefore incidence and burden of Alzheimer’s disease is higher.

Content analysis of the publications also reveals an opportunity for future research: although Alzheimer’s disease disproportionately affects women, research using humans and animal models disproportionately features men or male subjects.

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Subjects, Products & Services: Analytical Services; Pure; SciVal; Scopus

Uploaded: 2019-08-26 07:16:23