WHO Guidelines fail to detect half of chronic hepatitis B patients in Ethiopia needing treatment

Scientists propose revising the guidelines to take data from sub-Saharan Africa into account, reports the Journal of Hepatology


Amsterdam, March 28, 2019

Current World Health Organization (WHO) guidelines for chronic hepatitis B (CHB) fail to detect half of the patients in need of treatment in Ethiopia, report scientists in the Journal of Hepatology, published by Elsevier. They propose revising the guidelines to consider local data from sub-Saharan Africa in order to help reach the WHO goal of eliminating viral hepatitis as a major public health threat by 2030.

Globally, an estimated 257 million people are living with CHB virus infection. Without timely treatment, one fifth of these individuals will die due to liver damage or liver cancer. In 2015, the WHO issued guidelines for management of CHB, which recommend starting treatment in patients who fulfil certain criteria. Antiviral therapy prevents disease progression and death in patients with CHB, but identification of patients in need of treatment is challenging in low- and middle-income countries. These guidelines are based on data from Europe, America, and Asia. Almost half of the world’s population resides in areas of high hepatitis B occurrence, with the highest prevalence in Africa and East Asia. It has not been established whether the WHO criteria are suitable in sub-Saharan Africa.

“The number of hepatitis B-related deaths has increased steadily over the past 25 years, and it is now estimated to kill nearly 900,000 people every year,” explained lead investigator Asgeir Johannessen, MD, PhD, Regional Centre for Imported and Tropical Diseases, Oslo University Hospital, Oslo, Norway. “In 2016, the WHO set an ambitious goal of eliminating viral hepatitis as a major global public health threat by 2030, and many countries in sub-Saharan Africa are developing national hepatitis B care and treatment plans. To achieve WHO’s elimination goal it is vital to develop more precise tools to identify the patients in this region who need treatment.”

To test the effectiveness of the WHO criteria in Africa, investigators from Norway and Ethiopia assessed a large cohort of around 1,200 patients with CHB in Ethiopia - a low-income country in East Africa and one of the most populous nations on the continent with approximately 100 million inhabitants. Based on different clinical studies, the overall prevalence of CHB is estimated at 7.4 percent.

Treatment-naïve adults who attended a public CHB clinic in Addis Ababa were included in this analysis. All patients underwent standardized evaluation at recruitment, including blood tests and transient elastography using Fibroscan. A Fibroscan result of 7.9 kPa or more was used to define significant fibrosis and 9.9 kPa or more to define cirrhosis. Treatment eligibility was assessed using the most recent guidelines from the European Association for the Study of the Liver (EASL) as the “gold standard.”

The consequence of using the WHO treatment criteria in sub-Saharan Africa is that many patients with significant liver disease never receive life-saving therapy.

Out of 1,190 patients with CHB, 300 (25.2 percent) were eligible for treatment based on the EASL 2017 guidelines and 182 (15.3 percent) based on the WHO 2015 guidelines. Of concern, only half of those in need of treatment were identified using the WHO criteria. After excluding patients in obvious need of therapy (i.e., individuals with visible signs of advanced liver disease), only one quarter of the remaining patients were detected using the WHO criteria. Most patients (94 of 182; 51.6 percent) who met the WHO criteria had decompensated cirrhosis indicating the possibility of a dismal prognosis even with therapy.

“Our results clearly show that the WHO treatment criteria lack precision in sub-Saharan Africa,” said Dr. Johannessen. “If the current WHO guidelines are applied, millions of Africans living with CHB will be excluded from life-saving treatment. A revision of the WHO guidelines clearly needs to consider local data from sub-Saharan Africa.”

In an accompanying editorial, Geoffrey Dusheiko, MD, MB, BCh, FRCP, Kings College Hospital and University College London Medical School, London, UK, and Maud Lemoine, MD, MSc, PhD, Department of Surgery and Cancer, Liver Unit, St Mary’s Hospital, Imperial College London, UK, question whether it is judicious for low-income African countries to prioritize hepatitis B virus (HBV) antiviral treatment for individuals with advanced fibrosis and cirrhosis, as in the WHO criteria. They argue that patients on the African continent who test positive for hepatitis B surface antigen (HBsAg) should have more widespread access to measurement of serum HBV DNA and serum aminotransferases, outside of urban centers, in order to match eligibility for treatment applicable in other regions of the world.

“We should no longer hold to the tenet that such a disadvantageous ranking, specifying treatment mainly for those with ominous advanced hepatic fibrosis or hepatocellular failure, should inevitably apply in resource-limited sub-Saharan Africa,” commented Dr. Dusheiko. “Guidelines in African countries should encompass criteria that would steer treatment toward obviating the development of cirrhosis, thus preventing the onset of decompensated cirrhosis, and, based on evidence in other studies, reduce the risk of liver cancer to that of HBsAg-positive patients without cirrhosis.”

Dr. Lemoine added “To increase treatment coverage to 80 percent of those requiring treatment of CHB by 2030 as requested by the WHO, it is likely that African countries will have to adapt screening and treatment strategies.

“People living in both urban and rural areas will need access to simplified, workable but more accurate diagnostic and monitoring algorithms.”

This Ethiopian study combined with other recent studies from West Africa represents an important opportunity for the WHO and African countries to formulate appropriate guidelines for the management and treatment of hepatitis B in Africans.

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Notes for editors
The articles are “The WHO guidelines for chronic hepatitis B fail to detect half of the patients in need of treatment in Ethiopia,” by Hanna Aberra; Hailemichael Desalegn; Nega Berhe; Bitsatab Mekasha; Girmay Medhin; Svein G Gundersen; and Asgeir Johannessen ( http://dx.doi.org/10.1016/j.jhep.2019.01.037 ); and “An appraisal of the WHO hepatitis B treatment guidelines applicable to Africans,” by Geoffrey Dusheiko and Maud Lemoine (https://doi.org/10.1016/j.jhep.2019.03.009). They will appear in the Journal of Hepatology, volume 70, issue 6 (June 2019) published by Elsevier.

Full text of these articles is available to credentialed journalists upon request; contact Carolien van der Zanden at +31 20 485 3346 or hmsmedia@elsevier.com. Journalists wishing to interview the study authors should contact Asgeir Johannessen +47 97983264 or johannessen.asgeir@gmail.com. Geoffrey Dusheiko may be reached for comment at +44 797 714 7834 or g.dusheiko@ucl.ac.uk.

The hepatitis B program at St. Paul’s Hospital Millennium Medical College was established in 2015 in collaboration with Oslo University Hospital and Addis Ababa University. The study was funded by The Norwegian Research Council, grant number 220622/H10, and the South-Eastern Norway Regional Health Authority, grant number 2011068.

About the Journal of Hepatology
The Journal of Hepatology is the official journal of the European Association for the Study of the Liver (EASL). It publishes original papers, reviews, case reports, and letters to the Editor concerned with clinical and basic research in the field of hepatology. www.journal-of-hepatology.eu

About EASL
In the fifty plus years since EASL was founded, it has grown from a small organization that played host to 70 participants at its first meeting, to becoming the leading liver association in Europe. EASL attracts the foremost hepatology experts as members and has an impressive track record in promoting research in liver disease, supporting wider education, and promoting changes in European liver policy. www.easl.eu

About Elsevier
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Media contact:
Carolien van der Zanden
Elsevier
+31 20 485 3346
hmsmedia@elsevier.com