Premature deaths from alcoholic liver disease rising as gap between men and women narrows

Since the early 2000s, alcoholic liver disease deaths among non-Hispanic whites, particularly women, have increased more rapidly than rates among other ethnic groups, reports a new study in the American Journal of Preventive Medicine


Ann Arbor, August 27, 2020

A new study in theAmerican Journal of Preventive Medicine, published by Elsevier, identifies emerging patterns in the rate of and age at premature death from alcoholic (alcohol-associated) liver disease (ALD) in the United States over the last two decades. Significantly, the study documents that since the early 2000s, ALD death rates among non-Hispanic whites, particularly women, have increased more rapidly than rates among non-Hispanic blacks. Findings indicate that mortality is significantly impacted by socioeconomic and sociodemographic factors, the clinical course of ALD, and co-existing conditions.

“Empirical evidence from our study adds to the growing literature suggesting that previously large gaps between women and men in alcohol-related harms, including mortality, are narrowing,” explained co-investigator Aaron M. White, PhD, Senior Scientific Advisor to the Director, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA. “Of particular concern is the largest increase that occurred among younger women ages 25–34. Because it usually takes 10 or more years of drinking to develop liver disease, premature mortality before 35 years of age is quite unusual and cause for serious public health concerns.”

Investigators drew death certificate data from the 1999–2018 Multiple Cause of Death database compiled by the National Center for Health Statistics. Each death certificate contains a single underlying cause of death, up to 20 additional contributing causes, and sociodemographic data. From 1999 to 2018, 281,243 individuals ages 25–69 died prematurely of ALD. Researchers looked at other factors reported as contributing to the cause of death: demographic characteristics (e.g., sex, race/Hispanic origin, marital status, education); the type of ALD (e.g., alcoholic fatty liver, alcoholic hepatitis; alcoholic cirrhosis of the liver); and comortalities (e.g., alcohol use disorder, tobacco use disorder, hepatitis C infection, diabetes, hypertension, injuries).

Highlights of the study’s findings include:

  • Although men consistently had higher ALD death rates, gaps between men and women for ALD death rates have narrowed in the past two decades, especially among people ages 25–34 years. The rate ratio of men to women dropped from roughly 3:1 in 1999 to 2:1 in 2018.
  • Women died of ALD on average about two to three years earlier than men, possibly due to the more rapid increase in alcohol misuse and relatively higher occurrence of alcoholic hepatitis in women at younger ages, coupled with higher prevalence of severe obesity among women.
  • Years of potential life lost (YPLL), an indicator of premature death, increased more rapidly for women than men, especially after the economic recession in 2008. Since then, individuals with less than a college education, irrespective of sex, experienced a more rapid increase in ALD death rates than their college-educated counterparts.
  • Compared to non-Hispanic whites, the age-adjusted ALD death rates among non-Hispanic blacks have been either declining or stagnant during this period or slowly increasing since 2008.
  • Alcohol involvement in liver disease remained highest among Hispanics. Historically, sex disparities in drinking were more pronounced in Hispanics than in other racial/ethnic groups. The authors suggest that heightened rates among Hispanic women may be attributed to increases in female drinking driven by acculturation.


Age-adjusted rates of premature deaths from liver disease and alcoholic liver disease among U.S. population ages 25–69, by sex and race/Hispanic origin, 1999–2018 (Credit: American Journal of Preventive Medicine).

The authors conclude that the study supports population-level interventions and policies to reduce alcohol consumption and improve access to, and quality of, ALD treatment. Their findings may serve to raise public awareness of the rising levels of death from ALD and the groups at greatest risk, encouraging both physicians and patients to engage more frequently in discussions about alcohol consumption. To address narrowing sex gaps in premature death from ALD, greater emphasis should be placed on implementation of abstinence programs, early detection of ALD, and education about hazardous drinking levels for women.

Dr. White cautioned: “Because alcohol consumption tends to increase during periods of economic uncertainty, ALD mortality could spike as the current economic crisis persists. In addition, disruption of quality care delivery could increase rates of mortality in patients with end-stage ALD while disruption of alcohol use disorder treatment and recovery programs could lead to relapses and exacerbation of ALD.

---

Notes for editors
The article is“Trends in Premature Deaths From Alcoholic Liver Disease in the U.S., 1999–2018,” by Young-Hee Yoon, PhD, Chiung M. Chen, MA, Megan E. Slater, PhD, M. Katherine Jung, PhD, and Aaron M. White, PhD (https://doi.org/10.1016/j.amepre.2020.04.024). It will appear in the American Journal of Preventive Medicine, volume 59, issue 4 (October 2020) published by Elsevier.

This article is based on a study conducted for the Alcohol Epidemiologic Data System project funded by the National Institute on Alcohol Abuse and Alcoholism, NIH, through Contract No. HHSN275201800004C to CSR, Incorporated.

Full text of this article is available to credentialed journalists upon request; contact Jillian B. Morgan at +1 734 936 1590 or ajpmmedia@elsevier.com. It will also be openly available for 60 days following publication. Journalists wishing to interview the authors should contact Dr. Aaron White at +1 301 451 5943 or aaron.white@nih.gov.

About the American Journal of Preventive Medicine
The American Journal of Preventive Medicine is the official journal of the American College of Preventive Medicine and the Association for Prevention Teaching and Research. It publishes articles in the areas of prevention research, teaching, practice and policy. Original research is published on interventions aimed at the prevention of chronic and acute disease and the promotion of individual and community health. The journal features papers that address the primary and secondary prevention of important clinical, behavioral and public health issues such as injury and violence, infectious disease, women's health, smoking, sedentary behaviors and physical activity, nutrition, diabetes, obesity, and alcohol and drug abuse. Papers also address educational initiatives aimed at improving the ability of health professionals to provide effective clinical prevention and public health services. The journal also publishes official policy statements from the two co-sponsoring organizations, health services research pertinent to prevention and public health, review articles, media reviews, and editorials. www.ajpmonline.org

About Elsevier
Elsevier is a global information analytics business that helps scientists and clinicians to find new answers, reshape human knowledge, and tackle the most urgent human crises. For 140 years, we have partnered with the research world to curate and verify scientific knowledge. Today, we’re committed to bringing that rigor to a new generation of platforms. Elsevier provides digital solutions and tools in the areas of strategic research management, R&D performance, clinical decision support, and professional education; including ScienceDirect, Scopus, SciVal, ClinicalKey and Sherpath. Elsevier publishes over 2,500 digitized journals, including The Lancet and Cell, 39,000 e-book titles and many iconic reference works, including Gray's Anatomy. Elsevier is part of RELX, a global provider of information-based analytics and decision tools for professional and business customers. www.elsevier.com

Media contact
Jillian B. Morgan, MPH, Managing Editor
AJPM
+1 734 936 1590
ajpmmedia@elsevier.com