The best treatment for bedbug bites involves symptomatic relief primarily through the use of topical glucocorticoids and systemic antihistamines, alongside measures to prevent infection and eradicate the bedbugs.[1-3]
- Apply triamcinolone cream 0.1% bid to affected areas to reduce inflammation and itching.[1] 
- Administer chlorpheniramine 4 mg PO at bedtime for adults and 2 mg PO at bedtime for children to manage pruritus.[1] 
- Encourage patients to avoid scratching the bites to prevent secondary infection.[1] 
- Implement environmental controls such as washing bedding at high temperatures, using mattress covers, and employing professional pest control services for effective eradication.[1-3] 
- Consider non-pharmacologic measures like vacuuming and using steam treatments on mattresses to reduce bedbug populations.[1]