Skip to main content

Unfortunately we don't fully support your browser. If you have the option to, please upgrade to a newer version or use Mozilla Firefox, Microsoft Edge, Google Chrome, or Safari 14 or newer. If you are unable to, and need support, please send us your feedback.

Publish with us
Muscularis Mucosae
Transverse Colon

Muscularis Mucosae

Lamina muscularis mucosae

Read more

Quick Facts

The lamina muscularis mucosae is the thin layer of smooth muscle fibers usually found as a part of the tunica mucosa deep to the lamina propria mucosae (Dorland, 2011).

Complete Anatomy
The world's most advanced 3D anatomy platform
Try it for Free


The muscularis mucosae is similar throughout the small and large intestine. It is the deepest part of the mucosa consisting of a very thin inner circular layer and an equally thin outer longitudinal layer of smooth muscle. Both layers tend to be thicker in the colon.

Anatomical Relations

The muscularis mucosae is the deepest part of the mucosa and adjacent to the submucosa. It has neither plicae circulares nor villi but has extensive straight tubular intestinal glands (crypts of Lieberkühn) that extend the full thickness of the mucosa (Ross and Pawlina, 2006).


Contraction of the muscularis mucosae (independent of the peristaltic movement of the entire gut wall) moves the mucosa and forms ridges and depressions that facilitate absorption and movement of mucus from goblet cells to the luminal space.

List of Clinical Correlates

—Crohn's disease

—Ulcerative Colitis

—Mucosa associated lymphoid tissue (MALT) lymphoma


Dorland, W. (2011) Dorland's Illustrated Medical Dictionary. 32nd edn. Philadelphia, USA: Elsevier Saunders.

Ross, M. H. and Pawlina, W. (2006) Histology: A text and atlas. Lippincott Williams & Wilkins.

Complete Anatomy

The world's most advanced 3D anatomy platform

Complete Anatomy