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Juxtaglomerular Epithelioid Cell
Renal Corpuscle

Juxtaglomerular Epithelioid Cell


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Quick Facts

Juxtaglomerular cells are specialized smooth muscle cells found in the tunica media of the afferent glomerular arterioles, containing secretory granules. They are the major structural component responsible for the release of renin and play a major role in renal autoregulation and tubuloglomerular feedback (Dorland, 2011).

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Related parts of the anatomy

Structure and/or Key Feature(s)

The juxtaglomerular apparatus includes the macula densa and the juxtaglomerular and mesangial cells.

The distal straight tubule traverses the medulla into the cortex within a medullary ray and aligns itself adjacent to the vascular pole of the renal corpuscle with which it is a component. A clustering of nuclei of epithelial cells lining the distal straight tubule directly adjacent to the afferent arteriole close to the vascular pole of the renal corpuscle form the “macula densa.”

Smooth muscle cells of the adjacent afferent, and sometimes efferent, arterioles exhibit spherical nuclei and their cytoplasm contain secretory granules.


The juxtaglomerular apparatus regulates blood pressure by activating the renin-angiotensin-aldosterone system. It also sensors blood volume and tubular fluid composition. The macula densa monitors Na+ concentration within the tubular fluid and regulate glomerular filtration rate and the release of renin from the juxtaglomerular cells (Ross and Pawlina, 2006).


Dorland, W. (2011) Dorland's Illustrated Medical Dictionary. 32nd edn. Philadelphia, USA: Elsevier Saunders.

Ross, M. H. and Pawlina, W. (2006) Histology: A text and atlas. Lippincott Williams & Wilkins.

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