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Perilymph of Scala Vestibuli

Perilymph of Scala Vestibuli

Perilympha scalae vestibuli

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Quick Facts

Perilymph is the fluid contained within the space separating the membranous labyrinth from the osseous labyrinth; it is entirely separate from the endolymph (Dorland, 2011).

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Structure and/or Key Feature(s)

The scala vestibuli is filled with perilymph, an extracellular fluid that is similar in consistency to that of cerebrospinal fluid and is dominant in sodium ions. In addition, its composition differs from the perilymph of the scala tympani in that it possesses higher concentrations of potassium, glucose, amino acids, and proteins. Given this, it is proposed that the perilymph of the scala vestibuli is derived from the endothelium of cochlear blood vessels (Standring, 2016).


The perilymph serves as a medium to transmit vibrations from the tympanic membrane (via the ossicles) to the endolymph in the cochlear duct, thus stimulating the spiral organ (of Corti). It also receives effluxing potassium released by the depolarization of the stereocilia.

The perilymph plays an important role in the sensory cell depolarization, as it receives the efflux of potassium from calcium-dependent channels in the stereocilia hair cells. It also contributes to the influx of calcium through specific channels located on the side and basal aspects of the hair cells.


Dorland, W. (2011) Dorland's Illustrated Medical Dictionary. 32nd edn. Philadelphia, USA: Elsevier Saunders.

Standring, S. (2016) Gray's Anatomy: The Anatomical Basis of Clinical Practice., 41st edition. Elsevier Limited.

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