Speakers will include
Stanford University, USA
University of Glasgow, UK
University of Zurich, Switzerland
University of Oxford, UK
The Scripps Research Institute, San Diego, USA
Winner of the 2019 Tetrahedron Young Investigator Award for Organic Synthesis
Complex secondary metabolites form the foundation of research in Dr. Ryan Shenvi’s lab. His group has devised chemical syntheses of amphilectene, diisocyanoadociane and kalihinol isonitriles, Nuphar thiaspirane dimers, lepadiformine, jiadifenolide, O-debenzoyl-tashironin, 20-nor-salvinorin A and others.
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Methodological gaps identified by these studies have led to the development a broadly-applied radical hydrogenation reaction, stereospecific tertiary alcohol substitution, carboxylate-directed Heck reaction, chemoselective alkene isomerization and a dual-catalytic reaction platform to form quaternary carbons from unactivated alkenes. Both total synthesis and method development have led to mechanistic discoveries including the hyperexcitation of neurons by the ‘neurotrophic terpenes,’ sesquestration of the labile iron pool by the asmarine alkaloids, a hydrogen atom transfer elementary step in Drago-Mukaiyama reactions, and a direct Co to Ni transmetalation without cage escape. The idea of changing retrosynthetic analysis by target design gets Ryan out of bed in the morning, when his kids do not.
Of winning the award Dr. Shenvi said “I’m surprised and honored to be listed among the distinguished awardees. Group members past and present, collaborators and colleagues deserve recognition for their many contributions to my lab’s work. The whole field of complex molecule synthesis merits reward for the expansion of natural product-like molecular divrsity within synthetic collections and its impact on drug discovery."
Winner of the 2019 Tetrahedron Young Investigator Award for Bioorganic and Medicinal Chemistry
Dr. Raphaël Rodriguez joined the CNRS as a group leader in 2012 and was subsequently promoted as a Research Director in March 2017. His laboratory focuses on the chemical synthesis of complex small molecules and the development of cell biology protocols to investigate processes relevant to human diseases.
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His recent endeavors led to elucidating cellular mechanisms involved in aging and revealed a prevalent role of metals in the regulation of the epithelial-to-mesenchymal transition in cancer.
“I am truly honored to be a recipient of the Tetrahedron Young Investigator Award. It is overwhelming to join such a distinguished group of inspiring scientists, an incredible recognition for all the dedicated and talented collaborators I had the good fortune to work with over the years. I sincerely hope our continuing efforts will provide creative solutions to challenges of our time”, Dr. Rodriguez commented.
Chulalongkorn University, Thailand
Wuhan University, China
Full biography coming soon.