Trends in Endocrinology and Metabolism article debunks cancer rate and sperm count myths
There is a widely-held belief that sperm counts are decreasing globally and that rates of female breast cancer and male reproductive tract problems are generally increasing. However, Dr Stephen Safe, writing in the May issue of Trends in Endocrinology and Metabolism, argues that there is little evidence to suggest that either of these beliefs is true and that public concern regarding these issues, heightened by media reports, is ill-founded. Furthermore, he suggests that Endocrine Disrupting Chemicals (EDCs), long hypothesized to be linked to the above conditions, are unlikely to be causal factors.
There has been a great deal of research to investigate the potentially adverse effects of EDCs, synthetic and naturally occurring compounds such as environmental estrogens, human exposure of which results from dietary intake as trace contaminants in food. Safe writes that “humans are exposed to high levels of dietary endocrine-active compounds in fruit, vegetables and other food products and therefore, lower and even trace levels of contaminant EDCs would have a negligible impact on overall EDC exposure and impact.” The concept of the Precautionary Principle meant that research was set in motion to investigate how EDCs relate to conditions such as cancers and sperm counts. However, this research has proved largely inconclusive in establishing any harmful effects.
Results of studies during the past 12 years have indicated an overwhelming lack of evidence to support a link between exposure to EDC compounds and development of breast cancer. Several studies have shown that levels of EDCs in breast cancer patients are not significantly different to the matched controls, which would indicate that they are not a factor in incidence rates.
Research indicates neither an increase nor decrease in global sperm counts, although there is evidence of regional differences in sperm counts and quality within countries. However, a general population-based study of young men in Denmark showed no association between sperm count and certain EDCs. It is unlikely that EDCs are linked to regional differences in sperm counts or quality as exposure to EDCs is largely consistent within most countries and regions.
There are also large demographic variations in incidence rates of testicular cancer, which must also therefore be attributable to other etiological factors, especially since levels of organochlorine pollutants are decreasing in most locations. It has been estimated that more than 80% of the risk of most cancers is associated with genetic variables designated as environmental factors, which include exposure to contaminants, lifestyle and diet. Safe concedes that “there may be other human health problems linked to high exposure to organochlorine contaminants” but, in the absence of any evidence to suggest that EDCs affect rates of breast and testicular cancer, sperm counts and fertility, states that it is now time to propose new hypotheses to concentrate on other etiological factors.
About Trends in Endocrinology and Metabolism
Trends in Endocrinology and Metabolism, with its polished, concise and readable reviews, Research News, Meeting reports and discussions of topics at the cutting edge of endocrinology, covers both clinical and research aspects of the field, from state-of-the-art treatments of endocrine diseases to new developments in molecular biology, thus serving as an invaluable source of information for researchers, clinicians, lecturers, teachers and students.
Elsevier is a global information analytics business that helps scientists and clinicians to find new answers, reshape human knowledge, and tackle the most urgent human crises. For 140 years, we have partnered with the research world to curate and verify scientific knowledge. Today, we’re committed to bringing that rigor to a new generation of platforms. Elsevier provides digital solutions and tools in the areas of strategic research management, R&D performance, clinical decision support, and professional education; including ScienceDirect, Scopus, SciVal, ClinicalKey and Sherpath. Elsevier publishes over 2,500 digitized journals, including The Lancet and Cell, 39,000 e-book titles and many iconic reference works, including Gray's Anatomy. Elsevier is part of RELX Group, a global provider of information and analytics for professionals and business customers across industries. www.elsevier.com
For the full text version of this article and for more information about Trends in Endocrinology and Metabolism, contact the Editor Elsbeth Headley at firstname.lastname@example.org.You can view the current issue at http://www.sciencedirect.com/science/journal/10432760