Milk Proteins May Protect Against Cardiovascular Disease

Naturally-Fermented Foods Are a Good Source, According to New Journal of Dairy Science® Study

Philadelphia, PA, June 11, 2015

The Maillard reaction is a chemical reaction between amino acids and reducing sugars that results in browned foods like seared steaks and toasted bread. When proteins and sugars are mixed together and heated, new chemical compounds are formed. Some are responsible for new flavors and some, according to a new study published in the Journal of Dairy Science®, may protect us against cardiovascular disease.

Researchers at the R&D Center, Seoul Dairy Cooperative, the College of Life Science & Biotechnology, Korea University, and the BK21 Plus Graduate Program, Department of Animal Science and Institute Agricultural Science & Technology, Chonbuk National University in South Korea, have determined that dietary compounds formed in milk-based products lowered serum total and low-density lipoprotein (LDL) cholesterol levels and triglycerides in mice. These compounds also protected against acute pulmonary thromboembolism as well as aspirin, but without the possible bleeding consequences often observed in aspirin therapy.

Whey protein concentrate and sodium caseinate were heated with lactose to form whey-protein Maillard reaction products (wMRP). Lactic acid bacteria were then used to produce fermented MRPs (f-MRP). Sodium caseinate alone was also reacted to form Maillard-reacted sodium caseinate (cMRP) and further fermented to f-cMRP.

To determine antithrombotic effects, 60 mice were divided into four treatment groups of 15. Group 1 received phosphate buffered saline (PBS) (negative control), group 2 received aspirin (positive control), group 3 received wMRP, and group 4 received f-MRP in addition to a normal diet. Assessment of antioxidant activity and cholesterol reduction effect of fermented cMRP was done with another group of 60 mice fed various diets with and without f-cMRP.

“This is the first report describing the verification for the impacts of MRPs and their fermented product in cardiovascular risk using animal model,” explained lead investigator Younghoon Kim, PhD, of the Department of Animal Science, Chonbuk National University, Republic of Korea, “In addition, our findings represent a real advance in the area of milk proteins and indicate that f-cMRP and cMRP could be recommended for use as potential antioxidants and cardioprotective ingredients for various functional, pharmaceutical, and dairy applications.”

Matt Lucy, PhD, Editor-in-Chief, Journal of Dairy Science, and Professor of Animal Science, University of Missouri, added, “We are beginning to understand that dairy products provide benefits to human health beyond the traditional nutrients. This study performed in laboratory animals demonstrates the potential for milk proteins found in naturally fermented foods to improve human cardiovascular health.”

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Notes for editors
“Dietary Maillard Reaction Products and Their Fermented Products Reduces Cardiovascular Risk in Animal Model,” by N. S. Oh,M. R. Park, K. W. Lee, S. H. Kim, Y. Kim, DOI: http://dx.doi.org/10.3168/jds.2015-9308, Journal of Dairy Science, published online in advance of Volume 98, Issue 8 (August 2015) by Elsevier.

Full text of this article is available to credentialed journalists upon request. Contact Eileen Leahy at +1 732-238-3628 or jdsmedia@elsevier.com to obtain copies. Journalists wishing to set up interviews with the authors should contact Younghoon Kim, PhD, at +82-63-270-2606, +82-10-4135-2584 (cell), +82-63-270-2612 (fax), ykeys2584@jbnu.ac.kr, or ykeys2584@gmail.com.

About Journal of Dairy Science®
Journal of Dairy Science (JDS), official journal of the American Dairy Science Association, is co-published by Elsevier and the Federation of Animal Science Societies for the American Dairy Science Association. It is the leading general dairy research journal in the world. JDS readers represent education, industry, and government agencies in more than 70 countries with interests in biochemistry, breeding, economics, engineering, environment, food science, genetics, microbiology, nutrition, pathology, physiology, processing, public health, quality assurance, and sanitation. JDS is ranked number 2 in the Agriculture, Dairy and Animal Science category of the 2013 Journal Citation Reports®, published by Thomson Reuters, with a 5-year Impact Factor of 3.080. www.journalofdairyscience.org

About the American Dairy Science Association (ADSA)
The American Dairy Science Association (ADSA), a member of the Federation of Animal Science Societies (FASS), is an international organization of educators, scientists and industry representatives who are committed to advancing the dairy industry and keenly aware of the vital role the dairy sciences play in fulfilling the economic, nutritive, and health requirements of the world's population. It provides leadership in scientific and technical support to sustain and grow the global dairy industry through generation, dissemination, and exchange of information and services. Together, ADSA members have discovered new methods and technologies that have revolutionized the dairy industry. www.adsa.org

About Elsevier
Elsevier is a world-leading provider of information solutions that enhance the performance of science, health, and technology professionals, empowering them to make better decisions, deliver better care, and sometimes make groundbreaking discoveries that advance the boundaries of knowledge and human progress. Elsevier provides web-based, digital solutions — among them ScienceDirect, Scopus, Research Intelligence and ClinicalKey— and publishes over 2,500 journals, including The Lancet and Cell, and more than 35,000 book titles, including a number of iconic reference works. Elsevier is part of RELX Group, a world-leading provider of information and analytics for professional and business customers across industries. www.elsevier.com

Media contacts
Eileen Leahy
Elsevier
+1 732-238-3628
jdsmedia@elsevier.com

Ken Olson, PhD, PAS
American Dairy Science Association®
+1 630-237-4961
keolson@prodigy.net