Improving Outcomes in Premature Births

Nitroglycerin Shows Promise for Helping Preterm Infants

New York, March 26, 2007 – The costs due to complications from preterm birth are staggering. In Canada, outlays for specialized care of surviving preterm infants are estimated to be almost $2 billion per year. In a 5-year, randomized, placebo-controlled clinical study, researchers found that giving nitroglycerin to mothers who had entered premature labor led to significant improvement in their baby’s health. The results of the study are reported in the January issue of the American Journal of Obstetrics & Gynecology.

In previous studies of drugs to suppress labor contractions to allow the fetus more time to develop in utero, some drugs were able to delay delivery, but none improved the baby’s health outcome. This study is the first to show that the baby benefited from the therapy, especially those who are born very prematurely (at 24 to 28 weeks). Using a composite measure of the newborn’s health including perinatal death, markers of brain damage and serious lung and bowel complications, mothers treated with nitroglycerin had significantly healthier babies.

Graeme N. Smith, MD, PhD, states, "Our team is very excited about these findings. It is estimated that it costs the Canadian health system almost $2 billion a year to take care of premature babies and their medical complications. Given the immeasurable societal and family costs associated with preterm birth and having a sick baby or child, treatment with nitroglycerin may result in major cost saving and longer-term health benefits for these babies."

In an accompanying editorial, Associate Editor Jay D. Iams, MD, writes about the study, "Their work is notable not only for their interesting results but also for the quality of the study design, execution, and report." He continues, "Perhaps most importantly, the authors chose neonatal morbidity, a 'health outcome,' as the primary endpoint instead of a surrogate such as days gained or percent of births before 32 or 35 weeks of gestation."

The article is "Randomized double-blind placebo-controlled trial of transdermal nitroglycerin for preterm labor" by Graeme N. Smith, MD, PhD, Mark C. Walker, MD, MSc, Arne Ohlsson, MD, MSc, Karel O’Brien, MD and Rory Windrim, MD, MSc. The editorial is "Transdermal nitroglycerin for preterm labor" by Jay D. Iams, MD. Both appear in the American Journal of Obstetrics & Gynecology, Volume 196, Issue 1 (January 2007) published by Elsevier.

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Full text of the journal article and editorial mentioned above is available upon request. Contact Pamela Poppalardo, at (212) 633-3944 or ajogmedia@elsevier.com to obtain copies. They may also be accessed online at http://journals.elsevierhealth.com/periodicals/ymob/content/editorschoice

To schedule an interview with Dr. Smith, please contact him at gns@post.queensu.ca or 613 548 2405.

About The American Journal of Obstetrics & Gynecology
The American Journal of Obstetrics & Gynecology , known as "The Gray Journal," presents coverage of the entire spectrum of the field, from the newest diagnostic procedures to leading-edge research. The Journal provides comprehensive coverage of the specialty, including maternal-fetal medicine, reproductive endocrinology/infertility, and gynecologic oncology. It also publishes the annual meeting papers of several of its more than 30 sponsoring societies, including the Society for Maternal-Fetal Medicine and the Society of Gynecologic Surgeons. The American Journal of Obstetrics & Gynecology has the highest ranking for citation frequency of any ob/gyn journal and ranks in the top 1.7% of the 5,684 journals listed in the most recent Science Citation Index.

About Elsevier
Elsevier is a world-leading provider of information solutions that enhance the performance of science, health, and technology professionals, empowering them to make better decisions, deliver better care, and sometimes make groundbreaking discoveries that advance the boundaries of knowledge and human progress. Elsevier provides web-based, digital solutions — among them ScienceDirect, Scopus, Research Intelligence and ClinicalKey— and publishes over 2,500 journals, including The Lancet and Cell, and more than 35,000 book titles, including a number of iconic reference works. Elsevier is part of RELX Group, a world-leading provider of information and analytics for professional and business customers across industries. www.elsevier.com

Media Contact:
Pamela Poppalardo
Tel: +1 212 633-3944
E-mail: ajogmedia@elsevier.com