Atherosclerosis screening plus physical activity assessment give doctors a more accurate picture of mortality risk

Adding a single question about physical activity when performing coronary artery calcium scanning showed that elderly patients who report higher levels of physical activity have a lower risk of death than less active patients, according to a 10-year study published in Mayo Clinic Proceedings: Innovations, Quality & Outcomes


Rochester, MN, June 5, 2020

On a scale of 1 – 10, how much do you exercise (0-none, 10-always).” Adding this simple question when assessing elderly patients undergoing coronary artery calcium (CAC) scans can help clinicians better understand and treat patients, report scientists in Mayo Clinic Proceedings: Innovations, Quality & Outcomes, published by Elsevier.Elderly patients with high levels of atherosclerosis detected by CAC scans, who reported very frequent exercise, had a lower mortality rate than patients who reported getting little or no exercise and a mortality rate similar to patients with low levels of atherosclerosis who exercised rarely or never.

“Our study is the first to assess – and show – that this assessment of exercise activity in the elderly strongly influences the risk of death when significant atherosclerosis is detected on CAC scanning, explained lead investigator Alan Rozanski, MD, Professor of Medicine (Cardiology) at the Icahn School of Medicine at Mount Sinai, and Director of Nuclear Cardiology and Cardiac Stress Testing and Chief Academic Officer for the Department of Cardiology at Mount Sinai Morningside, New York, NY, USA.

“A notable aspect was that the use of just a single, self-reported question regarding exercise served to risk stratify older patients if they had elevated coronary artery calcium scores,” Dr. Rozanski added.

Cardiovascular diseases increase markedly with age and constitute a leading cause of death and disability in older adults. One underlying cause is advancing atherosclerosis, which can be evaluated by measuring the extent of CAC. There is growing interest in using CAC scanning as a simple and inexpensive means to determine which older patients are most at risk, and then assessing which interventions might modify that risk. Studies in middle-aged patients suggest that high levels of physical activity are associated with lower mortality and cardiac death rates among patients with atherosclerosis, but studies in elderly patients have been scarce.

The scientists identified 2,318 patients between the ages of 65 and 84 years who were referred for CAC screening between August 1998 and November 2016, and who died more than one year after the scan. The patients completed a questionnaire at the time of their scan, which asked about chest pain symptoms, cardiac risk factors, medication use, and physical activity. Patients self-reported their physical activity on a scale from 0-none to 10-always. Resting heart rate, blood pressure, height, and weight were recorded. Medical history of dyslipidemia, diabetes, hypertension, and smoking was identified.

The patients were followed for an average of 10.6 years to assess rates of death. During this time, 23 percent had died. For the entire cohort, the annualized mortality rate was 2.3 percent per year, with the highest mortality occurring among patients reporting low physical activity (2.9 percent per year) and the lowest mortality occurring among patients reporting high physical activity (1.7 percent per year).

Among patients with low CAC scores (0-99), survival was similar for each level of physical activity. In contrast, in patients with moderate CAC scores (100-399), the risk for all-cause mortality increased 2.07-fold among patients with low physical activity compared with patients with high physical activity. In patients with CAC scores over 400, all-cause mortality increased 2.35-fold for patients with low versus high activity.

Among all clinical parameters, age and the magnitude of CAC score were the most potent predictors of mortality. Notably, among all other variables, including chest pain symptoms, smoking, and obesity, physical activity was the next most potent predictor.


Relationship between self-reported physical activity among seniors >65 years old, the amount of atherosclerotic abnormality on CAC scanning and observed mortality during a mean follow up of 10.6 years.

Dr. Rozanski and colleagues noted that there are several factors that could explain the observations of this study. For example, patients who reported high physical activity had better health profiles, with lower frequency of hypertension, smoking, and diabetes. Of patients reporting high physical activity, only 7.7 percent were obese, while more than 25 percent of patients reporting low physical activity were obese.

“Our results indicate that a simple assessment of self-reported daily-life physical activity can substantially improve the effectiveness of CAC scanning for risk stratifying older adults and is strongly encouraged,” said Dr. Rozanski. “This is consistent with recent suggestions to make assessment of physical activity a ‘fifth vital sign’ that should be entered into patient electronic medical records, along with body temperature, pulse rate, respiration rate, and blood pressure.”

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Notes for editors
The article is “Associations Among Self-reported Physical Activity, Coronary Artery Calcium Scores, and Mortality Risk in Older Adults,” by Alan Rozanski, MD; Yoav Arnson, MD; Heidi Gransar, MS; Sean W. Hayes, MD; John D. Friedman, MD; Louise E.J. Thomson, MBChB; Damini Dey, PhD; and Daniel S. Berman, MD (https://doi.org/10.1016/j.mayocpiqo.2020.02.005). It appears in Mayo Clinic Proceedings: Innovations, Quality & Outcomes volume 4, issue 3 (June 2020) published by Elsevier . It is openly available.

Full text of the article is available to credentialed journalists upon request. Contact Brittney Binns at +1 215 297 3278 or mcpmedia@elsevier.com to obtain copies. Journalists wishing to interview the study authors should contact Ilana Nikravesh at +1 347 852 3382 or ilana.nikravesh@mountsinai.org.

About Mayo Clinic Proceedings: Innovations, Quality & Outcomes
Mayo Clinic Proceedings: Innovations, Quality & Outcomes (MCP:IQ&O) is an online-only, open access journal that - like its parent journal, Mayo Clinic Proceedings - is sponsored by Mayo Clinic. MCP:IQ&O broadens publication opportunities for pioneering and impactful clinical research on factors that affect contemporary healthcare delivery. The journal speaks through and to health care professionals and researchers interested in practice innovations, quality improvement, and outcomes research that optimize medical and surgical patient care. A dedicated and engaged editorial board ensures the highest standards of validity and relevance of its published content through rigorous peer review. mcpiqojournal.org

About Mayo Clinic
Mayo Clinic is a nonprofit worldwide leader in medical care, research, and education for people from all walks of life. For more information visit www.mayoclinic.org/about and www.mayoclinic.org/news.

About Elsevier
Elsevier is a global information analytics business that helps scientists and clinicians to find new answers, reshape human knowledge, and tackle the most urgent human crises. For 140 years, we have partnered with the research world to curate and verify scientific knowledge. Today, we’re committed to bringing that rigor to a new generation of platforms. Elsevier provides digital solutions and tools in the areas of strategic research management, R&D performance, clinical decision support, and professional education; including ScienceDirect, Scopus, SciVal, ClinicalKey and Sherpath. Elsevier publishes over 2,500 digitized journals, including The Lancet and Cell, 39,000 e-book titles and many iconic reference works, including Gray's Anatomy. Elsevier is part of RELX, a global provider of information-based analytics and decision tools for professional and business customers. www.elsevier.com

Media contact
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Elsevier
+1 215 297 3278
mcpmedia@elsevier.com