Journal of Allergy and Clinical Immunology
Notable articles of 2025
Dear Colleague,
To start off the new year, the Journal of Allergy and Clinical Immunology would like to take a look back at 2025 and highlight some of the most impactful articles of the past year. All of the papers in the collection below have been made free to read until the end of 2026 and many of them are open access, allowing you to access the full text beyond this year.
JACI top cited articles of 2025
First, we highlight the most cited articles of the year. The list is a testament to the broad scope of the journal and includes papers on topics such as: Inborn errors of immunity, atopic dermatitis, eosinophilic esophagitis, long Covid, chronic rhinosinusitis, and more.
Article from the special issue on genetic errors of immunity JAK-STAT signaling pathway, immunodeficiency, inflammation, immune dysregulation, and inborn errors of immunity Samra, S., Bergerson, J., Freeman, A.F., Turvey, S.E. Volume 155, Issue 2. p.357-367 February 2025 Open Access
Original article Effect of mepolizumab in airway remodeling in patients with late-onset severe asthma with an eosinophilic phenotype Domvri, K., Tsiouprou, I., Bakakos, P., Steiropoulos, P., Katsoulis, K., Kostikas, K., et al. Volume 155, Issue 2, p.425-435 February 2025 Open Access
Original article Phase 2b randomized clinical trial of amlitelimab, an anti-OX40 ligand antibody, in patients with moderate-to-severe atopic dermatitis Weidinger, S., Blauvelt, A., Papp, K.A., Reich, A., Lee, C.-H., Worm, M., et al. Volume 155, Issue 4, p.1264-1275 April 2025 Open Access
Original article Integrative epidemiology and immunotranscriptomics uncover a risk and potential mechanism for cutaneous lymphoma unmasking or progression with dupilumab therapy Cabrera-Pérez, J.S., Carey, V.J., Odejide, O.O., Singh, S., Kupper, T.S., Pillai, S.S., et al. Volume 155, Issue 5, p.1584-1594 May 2025 Open Access
Original article One-food versus 4-food elimination diet for pediatric eosinophilic esophagitis: A multisite randomized trial Kliewer, K.L., Abonia, J.P., Aceves, S.S., Atkins, D., Bonis, P.A., Capocelli, K.E., et al. Volume 155, Issue 2, p.520-532 February 2025
Original article Real-world effectiveness of dupilumab in a European cohort of chronic rhinosinusitis with nasal polyps (CHRINOSOR) Seys, S.F., Schneider, S., de Kinderen, J., Reitsma, S., Cavaliere, C., Tomazic, P.-V., et al. Volume 155, Issue 2, p.451-460 February 2025
Workshop summary Current status and future directions in food protein–induced enterocolitis syndrome: An NIAID workshop report of the June 22, 2022, virtual meeting Nowak-Węgrzyn, A., Sicherer, S., Akin, C., Anvari, S., Bartnikas, L.M., Berin, M.C., et al. Volume 155, Issue 2, p.336-356 February 2025
Original article Anaphylaxis definition, overview, and clinical support tool: 2024 consensus report—a GA2LEN project Dribin TE, Muraro A, Camargo Jr CA, Turner PJ, Wang J, Roberts G, et al. Volume 156, Issue 2, p.406-417.e6 August 2025 Open Access
Original article Targeting of the IL-5 pathway in severe asthma reduces mast cell progenitors Alvarado-Vazquez PA, Mendez-Enriquez E, Salomonsson M, Kopac P, Koren A, Bidovec-Stojkovic U, et al. Volume 155, Issue 4, p.1310-1320 April 2025 Open Access
Original article Dupilumab reduces inflammatory biomarkers in pediatric patients with moderate-to-severe atopic dermatitis Beck LA, Muraro A, Boguniewicz M, Chen Z, Zahn J, Marco AR. Volume 155, Issue 1, p.135-143 January 2025
JACI notable reviews of 2025
We have also selected a number of reviews that our Editors felt were worthy of highlighting for their contributions to furthering knowledge in the fields of Allergy, Asthma and Immunology.
Review article Omalizumab safety concerns Pongdee, T. & Li, J.T. Volume 155, Issue 1, p.31-35 January 2025
Review article Precision medicine for asthma treatment: Unlocking the potential of the epigenome and microbiome Perez-Garcia J, Cardenas A, Lorenzo-Diaz F, Pino-Yanes M. Volume 155, Issue 2, p.298-315 February 2025 Open Access
Review article Indoor bioaerosols and asthma: Overview, implications, and mitigation strategies Dannemiller KC, Conrad LA, Haines SR, Huang YJ, Marr LC, Siegel JA, et al. Volume 155, Issue 3, p.714-725 March 2025
Review article Long COVID: Pathophysiology, current concepts, and future directions Skevaki, C., Moschopoulos, C.D., Fragkou, P.C., Grote, K., Schieffer, E., & Schieffer, B. Volume 155, Issue 4, p.1059-1070 April 2025
Review article Novel insights on the biology and immunologic effects of histamine: A road map for allergists and mast cell biologists Heidarzadeh-Asl, S., Maurer, M., Kiani, A., Atiakshin, D., Stahl Skov, P., & Elieh-Ali-Komi, D. Volume 155, Issue 4, p.1095-1114 April 2025 Open Access
Review article Update on atopic dermatitis Meledathu, S., Naidu, M.P., Brunner, P.M. Volume 155, Issue 4, p.1124-1132 April 2025 Open Access
Review article Targeting alarmins in asthma: From bench to clinic Akenroye, A., Boyce, J.A., & Kita, H. Volume 155, Issue 4, p.1133-1148 April 2025
Review article Endotypes of atopic dermatitis Fyhrquist N, Yang Y, Karisola P, Alenius H. Volume 156, Issue 1, p.24-40.e4 July 2025 Open Access
Review article New insights into the endotypes of chronic rhinosinusitis in the biologic era Wang M, Li Y, Li J, Yan B, Wang C, Zhang L, Lan F. Volume 156, Issue 1, p.51-60 July 2025 Open Access
Review article Frequent exacerbator—a novel endotype of pediatric asthma Phelan KJ, Hershey GK. Volume 156, Issue 1, p.61-69 July 2025
Review article Eosinophilic esophagitis: An allergy and immunology perspective on the updated guidelines McGowan EC, Wright BL, Ruffner MA, Pesek RD, Rothenberg ME, Spergel JM, et al. Volume 156, Issue 2, p.252-258 August 2025
Review article Current and future landscape of Bruton tyrosine kinase inhibitors in allergy Lin EV, Arce B, Alvarez-Arango S, Dispenza MC. Volume 156, Issue 3, p.568-578 September 2025
Review article Personalized therapeutic approaches for asthma Agache I, Adcock IM, Baraldi F, Chung KF, Eguiluz-Gracia I, Johnston SL, et al. Volume 156, Issue 3, p.503-522 September 2025
Review article Mastering genetics for your clinic: A step-by-step guide Schindewolf E, Kilich G, Westerfer D, Vandergrift D, Rajagopalan R, Sullivan KE. Volume 156, Issue 5, p.1125-1132 November 2025
We hope that sharing this collection is helpful in guiding you to the research that our Editors and fellow researchers deemed to be most useful in 2025. Our goal is always to share and disseminate the most high-impact, cutting-edge basic, clinical and translational research papers in Allergy, Asthma and Immunology.
We couldn’t do this without the dedication and support of our authors, reviewers, and editors. Thank you for a fruitful 2025 and we look forward to an even more impactful 2026.
