Otto Warburg Medal Award

2024 Otto Warburg Medal Award

We are delighted to announce that the 2024 Otto Warburg Medal Award has been presented to Professor Dr. Johannes Buchner in recognition of his fundamental contributions to protein structure formation and the role of chaperones.

BBA Collection Otto Warburg 2024: Protein structure formation and the role of chaperones

This curated compilation, sourced from the family of ten BBA Journals over the period 2018-2024, serves as a tribute to Professor Dr. Johannes Buchner. Dr. Buchner is the 2024 recipient of the Otto Warburg Medal Award, an award which BBA is honoured to sponsor. Professor Buchner has made pioneering contributions to many different aspects of protein science, in particular to the role of chaperones in safeguarding protein folding and antibody stability. These proteins are “protectors”, either of the organism itself or of the many different proteins whose correct folding is a prerequisite for their function. The articles compiled are original research and reviews published across the BBA journals that illustrate the breadth and complexity of these proteins.

Structural studies of the Hsp70/Hsp90 organizing protein of Plasmodium falciparum and its modulation of Hsp70 and Hsp90 ATPase activities(opens in new tab/window) Noeli S.M. Silva, Dayane E. Bertolino-Reis, Paulo R. Dores-Silva, Fátima B. Anneta, Thiago V. Seraphim, Leandro R.S. Barbosa, Júlio C. Borges, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2020

Structural characterization of the N-terminal kinase-interacting domain of an Hsp90-cochaperone Cdc37 by CD and solution NMR spectroscopy(opens in new tab/window) Futoshi Ihama, Mami Yamamoto, Chojiro Kojima, Toshimichi Fujiwara, Katsumi Matsuzaki, Yoshihiko Miyata, Masaru Hoshino, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2019

Detection of key sites of dimer dissociation and unfolding initiation during activation of acid-stress chaperone HdeA at low pH(opens in new tab/window) Marlyn A. Widjaja, Jafaeth S. Gomez, Jonathon M. Benson, Karin A. Crowhurst, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2020

Biophysical characterization of human-cell-expressed, full-length κI O18/O8, AL-09, λ6a, and Wil immunoglobulin light chains(opens in new tab/window) Pinaki Misra, Alexander Tischer, Lindsey Lampe, Valeria Pierluissi-Ruiz, Christopher J. Dick, Benoit Bragantini, Nikita Kormshchikov, Matthew Auton, Marina Ramirez-Alvarado, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2024

Amyloid fibril formation by αS1- and β-casein implies that fibril formation is a general property of casein proteins(opens in new tab/window) Elmira Bahraminejad, Devashi Paliwal, Margaret Sunde, Carl Holt, John A. Carver, David C. Thorn, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2022

Engineering of conserved residues near antibody heavy chain complementary determining region 3 (HCDR3) improves both affinity and stability(opens in new tab/window) Merve Arslan, Tuğçe Uluçay, Seyit Kale, Sibel Kalyoncu, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2023

Structure and energetic basis of overrepresented λ light chain in systemic light chain amyloidosis patients(opens in new tab/window) Jun Zhao, Baohong Zhang, Jianwei Zhu, Ruth Nussinov, Buyong Ma, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2018

Inhibition of amyloid fibril formation in the variable domain of λ6 light chain mutant Wil caused by the interaction between its unfolded state and epigallocatechin-3-O-gallate(opens in new tab/window) Yoshito Abe, Naoki Odawara, Nantanat Aeimhirunkailas, Hinako Shibata, Naoki Fujisaki, Hirofumi Tachibana, Tadashi Ueda, Biochimica et Biophysica Acta (BBA) - General Subjects, 2018

Localized conformational changes trigger the pH-induced fibrillogenesis of an amyloidogenic λ light chain protein(opens in new tab/window) Isabel Velázquez-López, Gilberto Valdés-García, Sergio Romero Romero, Roberto Maya Martínez, Ana I. Leal-Cervantes, Miguel Costas, Rosana Sánchez-López, Carlos Amero, Nina Pastor, D. Alejandro Fernández Velasco, Biochimica et Biophysica Acta (BBA) - General Subjects, 2018

Chemical chaperone 4-phenylbutyric acid alleviates the aggregation of human familial pulmonary fibrosis-related mutant SP-A2 protein in part through effects on GRP78(opens in new tab/window) Xu Jiang, Guodong Fang, Li Dong, Peifeng Jin, Lu Ding, Haizeng Zhang, Junming Fan, Sunzhong Mao, Xiaofang Fan, Yongsheng Gong, Yongyu Wang, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2018

Protein quality control of DYRK family protein kinases by the Hsp90-Cdc37 molecular chaperone(opens in new tab/window) Yoshihiko Miyata, Eisuke Nishida, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2021

Molecular chaperone function of stress inducible Hsp70 is critical for intracellular multiplication of Toxoplasma gondii(opens in new tab/window) Pallabi Mitra, Abhijit S. Deshmukh, Chinmayee Choudhury, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2020

Amino acid transporter SLC6A14 depends on heat shock protein HSP90 in trafficking to the cell surface(opens in new tab/window) Karolina Rogala-Koziarska, Łukasz Samluk, Katarzyna A. Nałęcz, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2019

HSP90a promotes the resistance to oxaliplatin in HCC through regulating IDH1-induced cell competition(opens in new tab/window) Sikai Wang, Hongxia Cheng, Yilan Huang, Miaomiao Li, Dongmei Gao, Huaping Chen, Ruxiong Su, Kun Guo, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2024

A novel role of HSP90 in regulating osteoclastogenesis by abrogating Rab11b-driven transport(opens in new tab/window) Manh Tien Tran, Yuka Okusha, Yunxia Feng, Chiharu Sogawa, Takanori Eguchi, Tomoko Kadowaki, Eiko Sakai, Takayuki Tsukuba, Kuniaki Okamoto, Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2021

Prospects and challenges of noncoding-RNA-mediated inhibition of heat shock protein 90 for cancer therapy(opens in new tab/window) Shria Mattoo, Abha Gupta, Manvee Chauhan, Akshi Agrawal, Subrata Kumar Pore, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, 2024

DNAJB12 and DNJB14 are non-redundant Hsp40 redox chaperones involved in endoplasmic reticulum protein reflux(opens in new tab/window) Aline Dias da Purificação, Victor Debbas, Leonardo Yuji Tanaka, Gabriele Verônica de Mello Gabriel, João Wosniak Júnior, Tiphany Coralie De Bessa, Sheila Garcia-Rosa, Francisco Rafael Martins Laurindo, Percillia Victoria Santos Oliveira, Biochimica et Biophysica Acta (BBA) - General Subjects, 2023

Distinct dynamical features of plasmodial and human HSP70-HSP110 highlight the divergence in their chaperone-assisted protein folding(opens in new tab/window) Aradhya Tripathi, Sara Del Galdo, Balasubramanian Chandramouli, Niti Kumar, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2023

HSPA1A conformational mutants reveal a conserved structural unit in Hsp70 proteins(opens in new tab/window) Veronika Vandova, Pavla Vankova, Michal Durech, Josef Houser, Daniel Kavan, Petr Man, Petr Muller, Filip Trcka, Biochimica et Biophysica Acta (BBA) - General Subjects, 2020

Association of Hsp90 with p53 and Fizzy related homolog (Fzr) synchronizing Anaphase Promoting Complex (APC/C): An unexplored ally towards oncogenic pathway(opens in new tab/window) Sanghati Roy Chowdhury, Tirthankar Koley, Mandeep Singh, Abdul Samath Ethayathulla, Punit Kaur, Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2023

Human HSPA9 (mtHsp70, mortalin) interacts with lipid bilayers containing cardiolipin, a major component of the inner mitochondrial membrane(opens in new tab/window) Paulo Roberto Dores-Silva, David M. Cauvi, Vanessa T.R. Kiraly, Júlio C. Borges, Antonio De Maio, Biochimica et Biophysica Acta (BBA) – Biomembranes, 2020

Advances in chaperone-assisted RNA crystallography using synthetic antibodies(opens in new tab/window) Hasan Al Banna, Naba Krishna Das, Manju Ojha, Deepak Koirala, BBA Advances, 2023

The roles of the chaperone-like protein CpeZ and the phycoerythrobilin lyase CpeY in phycoerythrin biogenesis(opens in new tab/window) Christina M. Kronfel, Avijit Biswas, Jacob P. Frick, Andrian Gutu, Tyler Blensdorf, Jonathan A. Karty, David M. Kehoe, Wendy M. Schluchter, Biochimica et Biophysica Acta (BBA) – Bioenergetics, 2019