Understanding Disease Signaling Pathways and Biomarkers
Without an understanding of the biological systems processes that cause disease, it would be impossible to identify target proteins for new drugs. Similarly, identifying biomarkers for normal and abnormal states requires in-depth literature into the biological research. Whether scientists are focused on human pathology or plant biology, a solution that facilitates the interpretation of experimental data gives greater insight into the mechanisms of disease and accelerates biological research.
Real Stories. Real Science. Real Time.
Visit the Hive to explore how biotech and pharma start-ups are using Elsevier R&D solutions to solve for early-stage drug discovery and development. Watch videos, read real-world case studies and learn how early innovation starts with rapid results and early access to research that is crucial to reducing the likelihood of costly late stage failures and mitigating risk.
Pathway Studio Reveals the Underlying Biology
Pathway Studio enables the analysis and visualization of disease mechanisms, gene expression and proteomics and metabolomics data. It is an exhaustive resource of easily searchable molecular cell interactions. It also helps biological researchers import and analyze their experimental data using normalization and statistical tools to identify cause and possible effects on biological processes, using normalization and statistical tools. Browsing its expertly curated pathway libraries lets researchers model the impact of differential gene expression and protein-protein interactions on disease, streamlining the involved biological process of target identification.
Understanding the Effects of Genetic Mutations
The latest version of Pathway Studio allows biological researchers to browse and filter DNA variation data from Next Generation Sequencing (NGS) systems. The effects of those mutations on protein function, molecular cell interactions and disease progression can be examined via comparison to the results in the scientific literature.
By giving users the ability to review those relationships, and the corresponding literature sentences, Pathway Studio lets you make those changes on the fly and improve results, including or excluding relationships and assigning correct direction to the regulation. Philip Lorenzi, co-director of the Proteomics and Metabolomics Core Facility, MD Anderson Cancer Center Read the case study
Pathway Studio Fact Sheet
Discover the features that make Pathway Studio perfect for target and biomarker identification and validation.
Download the fact sheet (PDF, 961kb)
Supplement the information in Pathway Studio with detailed data on small molecules, chemicals and approved drugs. ChemEffect (PDF, 370kb) and DiseaseFX (PDF, 420kb) provide additional insight into diseases and their effects with data from the literature and ClinicalTrials.gov, enabling smooth transitions from data to hypotheses and potential targets.
Unraveling cell and immunology interactions relating to disease biology
CellEffect is a new data resource created for Pathway Studio that helps biological researchers explore the complex molecular interactions occurring within and between cells under normal conditions, and to better understand how these interactions change in disease. CellEffect supports in-house target and biomarker discovery programs and pathway analysis of clinical and experimental data by providing access to data derived from peer-reviewed research findings. Plus, CellEffect is compatible with Pathway Studio’s ChemEffect and DiseaseFX database extensions.
Take a deeper look at CellEffect (PDF, 1.2mb).
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Pathway Studio wins 2015 SIIA CODiE Award
Two of Elsevier's content products were named winners of 2015 SIIA CODiE Awards in three separate categories. Elsevier’s Pathway Studio won in the Best Science and Technology Information Solution category and Elsevier’s Reference Module in Chemistry, Molecular Sciences and Chemical Engineering won in the Best Scholarly Publishing Information Solution and Best General Reference Service categories. The SIIA CODiE Awards are the premier award for the software and information industries, and have been recognizing product excellence since 1986. The awards have over 85 categories and are organized by industry focus of Content, Education, and Software.
Read more (DOCX, 84kb)
Pathway Studio Plant
Designed to advance basic research and commercial bio-agriculture applications, Pathway Studio Plant (PDF, 343kb) provides a platform to explore well-studied plant model mechanisms, interpret experimental facts and build new signaling pathways for trait association, yield maximization and disease resistance research.