Series: Handbook of Clinical Neurology

The first volume of The Handbook of Clinical Neurology under the editorship of George Bruyn and Pierre Vinken was published in 1968. In 1982, the series was brought to an interim conclusion with the publication of the cumulative index volume (Volume 44). By that stage, the Handbook had come to represent one of the largest scientific works ever published. It enjoys a high reputation in specialist media circles throughout the world. After the series was concluded in 1982, it was realized that an update of the material was imperative. Accordingly, a revised series was planned and published over the following years, concluding with the publication of another cumulative index to both series (Volume 76-78) in 2002. Since then, the need for a further new series, incorporating advances in the field, again become necessary. Professors Michael J. Aminoff, François Boller and Dick F. Swaab have with enthusiasm taken on the responsibility of supervising the preparation of a third series, the first volumes of which were published in 2003. Now, more than 110 volumes after the first published, the Handbook in Clinical Neurology series continues to have an unparalleled reputation for providing the latest foundational research, diagnosis, and treatment protocols essential for both basic neuroscience research and clinical neurology. Edited by: - Michael Aminoff, Distinguished Professor, Department of Neurology, University of California, San Francisco, San Francisco, CA. - Francois Boller, Professor of Neurology, Department of Neurology, George Washington University Medical School, Washington,   DC, USA. - Dick Swaab, Netherlands Institute for Brain Research, University of Amsterdam, Amsterdam, The Netherlands.

Most recent volume


Volume TBD. The Frontal Lobes

Published: 1st May 2018

The Frontal Lobes serves to update the reader on the latest thinking on the structure and function of the human frontal lobe. The frontal lobe controls the highest cognitive and social functions of humans, is the most evolved area of the human brain, is affected in many neurological disorders, and its functions are important to many aspects of social participation. It has been argued that a better understanding of our frontal lobes will enable humans to better manage and improve their continuing evolution over the coming centuries.

Sections of the volume address methodology; anatomy, physiology and pharmacology; function; development, aging and disorders; and rehabilitation. Patients with focal lesions in the frontal lobes have long been studied to reveal the organization and function of the frontal lobes. Over the last two decades, studies of patients with neurodegenerative diseases and developmental disorders have increased and led to new findings regarding the functions of the frontal lobes, and those studies are discussed in this volume. Additionally, although understanding of the frontal lobe historically relied on detailed neuroanatomical and clinical studies of damage, methods now include genetics and molecular biology; optogenetics; high-resolution structural and functional neuroimaging and electrophysiology with healthy volunteers as well as patients; advanced cognitive neuroscience methods; and new training and treatment regimes. All these new approaches are highlighted in this volume. Lastly, with new knowledge about the biology, structure and function of the frontal lobes, new treatment targets for pharmacology, non-invasive brain stimulation, and cognitive/social remediation have emerged. The last section of the volume presents these new efforts that will hopefully lead to better outcomes in patients with frontal lobe disorders.

Additional volumes


Volume TBD. Metastatic Disease of the Nervous System

Published: 1st March 2018 Editors: David Schiff M J Van den Bent

Volume TBD. The Neurology of HIV Infection

Published: 1st January 2018 Editors: Peter Portegies Joseph Berger

Volume TBD. Brain Banking of Neurological and Psychiatric Diseases

Published: 1st January 2018

Volume TBD. Smell and Taste

Published: 1st January 2018 Editors: Richard L Doty Fidias E. Leon-Sarmiento

Volume TBD. Cerebrospinal Fluid in Neurological Research

Published: 1st January 2018

Volume TBD. Geriatric Neurology

Published: 1st January 2018

Volume TBD. Meningiomas

Published: 1st January 2018 Editors: Michael McDermott Philip Theodosopoulos

Volume 139. Functional Neurologic Disorders

Editors: Mark Hallett Jon Stone Alan Carson

Volume 999. Neurogenetics

Published: 1st September 2017 Editors: Daniel Geschwind Henry Paulson

Volume TBD. The Parietal Lobe

Published: 1st August 2017

Volume TBD. Arteriovenous Malformations

Published: 1st April 2017 Editors: Robert Spetzler Rami Almefty

Volume TBD. Cavernous Malformations

Published: 1st April 2017 Editors: Robert Spetzler Karam Moon

Volume TBD. Wilson Disease

Published: 1st March 2017 Editors: Anna Czlonkowska Michael Schilsky

Volume 141. Critical Care Neurology Part II

Published: 1st February 2017 Authors: Eelco Wijdicks Andreas Kramer

Volume 140. Critical Care Neurology Part I

Published: 1st February 2017 Authors: Eelco Wijdicks Andreas Kramer

Volume 138. Neuroepidemiology

Published: 23rd September 2016 Editors: Caterina Rosano M. Arfan Ikram Mary Ganguli

Volume 137. Neuro-Otology

Published: 23rd September 2016 Editors: Joseph M. Furman Thomas Lempert

Volume 136. Neuroimaging, Part II

Published: 1st January 2016 Editors: Joseph Masdeu R. Gilberto Gonzalez

Volume 135. Neuroimaging, Part I

Published: 1st January 2016 Editors: Joseph Masdeu R. Gilberto Gonzalez

Volume 134. Gliomas

Published: 20th May 2016 Editors: Mitchel Berger Michael Weller

Volume 133. Autoimmune Neurology

Published: 1st January 2016 Editors: Sean Pittock Angela Vincent

Volume 132. Neurocutaneous Syndromes

Published: 20th November 2015 Editors: Monica P. Islam E. Steve Roach

Volume 131. Occupational Neurology

Published: 23rd November 2015

Volume 130. Neurology of Sexual and Bladder Disorders

Published: 15th May 2015 Editors: David Vodusek Francois Boller

Volume 129. The Human Auditory System

Published: 19th February 2015 Editors: Gastone Celesia Gregory Hickok

Volume 128. Traumatic Brain Injury, Part II

Published: 12th February 2015 Editors: Jordan Grafman Andres Salazar

Volume 127. Traumatic Brain Injury, Part I

Published: 1st February 2015 Editors: Jordan Grafman Andres Salazar

Volume 126. Diabetes and the Nervous System

Published: 18th December 2014 Editors: Douglas Zochodne Rayaz Malik

Volume 125. Alcohol and the Nervous System

Published: 19th November 2014 Editors: Edith Sullivan Adolf Pfefferbaum

Volume 124. Clinical Neuroendocrinology

Published: 9th October 2014 Editors: Eric Fliers Marta Korbonits J.A. Romijn

Volume 123. Neurovirology

Published: 21st August 2014 Editors: Alex Tselis John Booss

Volume TBD. Brain-Computer Interfaces

Editors: Nick F. Ramsey Jose del R. Millan

Volume TBD. Human Prion Diseases

Volume 122. Multiple Sclerosis and Related Disorders

Published: 20th March 2014 Editor: Douglas Goodin

Volume TBD. Balance, Gait, and Falls

Authors: Brian Day Stephen Lord

Volume TBD. Thermoregulation

Volume 121. Neurologic Aspects of Systemic Disease, Part III

Published: 7th February 2014 Editors: José Biller José Ferro

Volume 120. Neurologic Aspects of Systemic Disease, Part II

Published: 7th February 2014 Editors: José Biller José Ferro

Volume 119. Neurologic Aspects of Systemic Disease, Part I

Published: 7th February 2014 Editors: José Biller José Ferro

Volume 118. Ethical and Legal Issues in Neurology

Published: 7th December 2013 Editors: James L. Bernat Richard Beresford

Volume 117. Autonomic Nervous System

Published: 19th November 2013 Editors: Ruud Buijs Dick Swaab

Volume 116. Brain Stimulation

Published: 25th November 2013 Authors: Andres Lozano Mark Hallett

Volume 115. Peripheral Nerve Disorders

Published: 1st September 2013 Editors: Gérard Said Christian Krarup

Volume 114. Neuroparasitology and Tropical Neurology

Published: 1st August 2013 Editors: Hector Garcia Herbert Tanowitz Oscar Del Brutto

Volume 113. Pediatric Neurology, Part III

Published: 17th May 2013

Volume 112. Pediatric Neurology, Part II

Published: 17th May 2013 Editors: Olivier Dulac Maryse Lassonde Harvey Sarnat

Volume 111. Pediatric Neurology, Part I

Published: 21st May 2013 Editors: Olivier Dulac Maryse Lassonde Harvey Sarnat

Volume 110. Neurological Rehabilitation

Published: 5th December 2012 Editors: Michael Barnes David Good

Volume 109. Spinal Cord Injury

Published: 21st November 2012 Editors: Joost Verhaagen John McDonald

Volume 108. Epilepsy, Part II: Treatment

Published: 9th October 2012 Editors: Hermann Stefan William Theodore

Volume 107. Epilepsy, Part I: Basic Principles and Diagnosis

Published: 10th October 2012 Editors: Hermann Stefan William Theodore

Volume 106. Neurobiology of Psychiatric Disorders

Published: 26th June 2012 Editors: Thomas Schlaepfer Charles Nemeroff

Volume 105. Neuro-Oncology, Part II

Published: 11th February 2012 Authors: Wolfgang Grisold Riccardo Soffietti

Volume 104. Neuro-Oncology Part I

Published: 11th February 2012 Editors: Wolfgang Grisold Riccardo Soffietti

Volume 103. Ataxic Disorders

Published: 21st September 2011 Editors: Sankara Subramony Alexandra Dürr

Volume 102. Neuro-ophthalmology

Published: 28th June 2011 Editors: Christopher Kennard R. John Leigh

Volume 101. Muscular Dystrophies

Published: 24th May 2011 Editors: Robert Griggs Anthony Amato

Volume 100. Hyperkinetic Movement Disorders

Published: 23rd May 2011 Editors: William Weiner Eduardo Tolosa

Volume 99. Sleep Disorders Part II

Published: 15th December 2010 Editors: Pasquale Montagna Sudhansu Chokroverty

Volume 98. Sleep Disorders Part I

Published: 16th December 2010 Editors: Pasquale Montagna Sudhansu Chokroverty

Volume 97. Headache

Published: 24th September 2010 Authors: Giuseppi Nappi Michael Moskowitz

Volume 96. Bacterial Infections of the Central Nervous System

Published: 23rd January 2010 Editors: Karen Roos Allan Tunkel

Volume 95. History of Neurology

Published: 8th December 2009 Editors: Stanley Finger Francois Boller Kenneth Tyler

Volume 94. Stroke, Part III: Investigation and management

Published: 12th November 2008 Editor: Marc Fisher

Volume 93. Stroke, Part II: Clinical Manifestations and Pathogenesis

Published: 12th November 2008 Editor: Marc Fisher

Volume 92. Stroke Part I: Basic and epidemiological aspects

Published: 17th November 2008 Editor: Marc Fisher

Volume 91. Neuromuscular Junction Disorders

Published: 4th August 2008 Editor: A. G. Engel

Volume 90. Disorders of Consciousness

Published: 6th June 2008 Editors: G. Bryan Young Eelco Wijdicks

Volume 89. Dementias

Published: 9th June 2008 Editors: Charles Duyckaerts Irene Litvan

Volume 88. Neuropsychology and Behavioral Neurology

Published: 15th April 2008 Editors: Georg Goldenberg Bruce Miller

Volume 87. Malformations of the Nervous System

Published: 26th September 2007 Editors: Harvey Sarnat Paolo Curatolo

Volume 86. Myopathies and Muscle Diseases

Published: 16th July 2007 Editors: Frank Mastaglia David Hilton-Jones

Volume 85. HIV/AIDS and the Nervous System

Published: 16th July 2007 Editors: Peter Portegies Joseph Berger

Volume 84. Parkinson's Disease and Related Disorders, Part II

Published: 25th June 2007 Authors: William Koller Eldad Melamed

Volume 83. Parkinson's Disease and Related Disorders Part I

Published: 25th June 2007 Editors: William Koller Eldad Melamed

Volume 82. Motor Neuron Disorders and Related Diseases

Published: 1st December 2006 Editors: Andrew Eisen Pamela Shaw

Volume 81. Pain

Published: 10th May 2006 Editors: Fernando Cervero Troels Jensen

Volume 80. Human Hypothalamus: Basic and Clinical Aspects, Part II

Published: 30th December 2003 Author: Dick Swaab

Volume 79. Human Hypothalamus: Basic and Clinical Aspects, Part I

Published: 15th December 2003 Author: Dick Swaab

Volume 78. Cumulative Subject Index of Volumes 1-75 (including Revised Series Volumes 1-31), Part 3: 0-Z

Published: 10th June 2002 Editors: P. J. Vinken G. W. Bruyn

Volume 77. Cumulative Subject Index of Volumes 1-75 (including Revised Series Volumes 1-31), Part 2: F-N

Published: 10th June 2002 Editors: P. J. Vinken G. W. Bruyn

Volume 76. Cumulative Subject Index of Volumes 1-75 (including Revised Series Volumes 1-31), Part 1: A-E

Published: 27th February 2002 Editors: P. J. Vinken G. W. Bruyn

Volume 000. Neuropathology

Published: 1st January 2018 Authors: Gabor Kovacs Irina Alafuzoff

Volume 000. Huntington’s Disease

Published: 1st July 2017 Editors: Andrew Feigin Karen E. Anderson