When You Can Recite a Poem But Not Remember Who Asked You to Learn it a Few Days Earlier

Damage to hippocampus very early in life hinders recollection of specific events but spares acquisition of general knowledge

Milan, Italy, August 11, 2011 – Memory is not a single process but is made up of several sub-processes relying on different areas of the brain. Episodic memory, the ability to remember specific events such as what you did yesterday, is known to be vulnerable to brain damage involving the hippocampus. The question is, what happens when damage to the hippocampus occurs very early in life? In a case study published in the September 2011 issue of Elsevier’s Cortex, clinical neuropsychologists have reported that a child can develop normally despite severe damage to the hippocampus resulting from lack of oxygen in the first days of life. This supports the theory that the different aspects of memory rely on distinct areas of the brain.

Dr. Claire Bindschaedler and Dr. Claire Peter-Favre from the Neuropsychology Unit of Lausanne’s University Hospital in Switzerland, together with their colleagues Prof. Philippe Maeder, Dr. Thérèse Hirsbrunner and Prof. Stephanie Clarke, investigated the case of a patient known as VJ, one of the few cases of developmental amnesia reported in the scientific literature. Repeated neuropsychological testing showed that VJ cannot remember being read a story or shown a picture half an hour earlier, or at least remembers little of it. At the same time however, VJ does do well on tests of general knowledge, also called semantic memory. In fact, when tested regularly over his childhood and teenage years, VJ was found to develop at the same rate as other children in areas of general knowledge and general intelligence.

Analysing MRI scans of VJ’s brain, Dr. Philippe Maeder found very severe atrophy (wasting away of brain tissue) in the hippocampi, while the adjacent area of the brain, known as the perirhinal cortex, was relatively spared from damage. This latter area is hypothesised to be important for the acquisition of semantic memory. These findings lend support to the idea that episodic memory (but not semantic memory) depends on the hippocampus.

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Notes to editors
The article is “Growing up with bilateral hippocampal atrophy: From childhood to teenage” by Claire Bindschaedler, Claire Peter-Favre, Philippe Maeder, Thérèse Hirsbrunner, Stephanie Clarke, and appears in Cortex, Volume 47, Issue 8 (September 2011),published by Elsevier in Italy. Full text of the article featured above is available to members of the media upon request. Please contact the Elsevier press office, newsroom@elsevier.com. To schedule an interview, contact Dr. Claire Bindschaedler,Claire.Bindschaedler@chuv.ch.

About Cortex
Cortex is an international journal devoted to the study of cognition and of the relationship between the nervous system and mental processes, particularly as these are reflected in the behaviour of patients with acquired brain lesions, normal volunteers, children with typical and atypical development, and in the activation of brain regions and systems as recorded by functional neuroimaging techniques. It was founded in 1964 by Ennio De Renzi. The Editor-in-Chief of Cortex is Sergio Della Sala, Professor of Human Cognitive Neuroscience at the University of Edinburgh. Fax: 0131 6513230, e-mail: cortex@ed.ac.ukCortex is available online at  http://www.sciencedirect.com/science/journal/00109452

About Elsevier
Elsevier is a global information analytics company that helps institutions and professionals progress science, advance healthcare and improve performance for the benefit of humanity. Elsevier provides digital solutions and tools in the areas of strategic research management, R&D performance, clinical decision support, and professional education; including ScienceDirect, Scopus, ClinicalKey and Sherpath. Elsevier publishes over 2,500 digitized journals, including The Lancet and Cell, more than 35,000 e-book titles and many iconic reference works, including Gray's Anatomy. Elsevier is part of RELX Group, a world-leading provider of information and analytics to professionals and business customers, in a wide range of industries. www.elsevier.com

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