Novel Coronavirus Information Center
Elsevier’s free health and medical research on novel coronavirus (2019-nCoV)
Welcome to Elsevier's Novel Coronavirus Information Center. Here you will find expert, curated information for the research and health community on Novel Coronavirus (also referred to as COVID-19 and its temporary title 2019-nCoV). All resources are free to access and include guidelines for clinicians and patients. Under the 'Research' tab you will find the latest early stage and peer-reviewed research from journals including The Lancet and Cell Press, as well as a link to the Coronavirus hub on ScienceDirect, where you will find every article relevant article to Coronavirus, SARS, and MERS freely available. Under the Clinical Solutions tab you will find resources for nurses, clinicians and patients, including FAQs on symptoms.
Margaret Trexler Hessen, MD, Director, Point of Care, Elsevier
Recent events have shown us (again) how rapidly a new disease can take root and spread. Such events are accompanied by an explosion of clinical and epidemiological information and research. The goal of this website is to open whatever resources we can to help public health authorities, researchers and clinicians contain and manage this disease. We will provide continually updated resources from Elsevier's content and experts. Our resources span scientific and medical journals and textbooks, educational products, and a variety of other resources, like travel precautions from the CDC and media posts of interest to our community. We have also created a interactive global map of experts based on Scopus data.
The site is curated by clinical experts from our Global Health business and updated frequently to keep pace with evolving knowledge.
Elsevier, Cell Press and The Lancet have also joined the signatories on the Wellcome Trust’s Statement designed to ensure that research findings and data relevant to this outbreak are shared rapidly and openly to inform the public health response and help save lives.
If you're looking for information on our other free and low-cost access programs, including resources for patients and caregivers, you can find that here.
Expert guidance and commentary
6 of the most common coronavirus questions the media is asking
By Rodney E. Rohde, PhD | Feb 6, 2020
As an infectious disease and clinical microbiology expert, Prof. Rodney E. Rohde of the Texas State University College of Health Professions receives daily calls from the media, government and university officials, and public health and professional organizations asking him about the emerging novel coronavirus outbreak. In this article, he shares some of the most common questions and his responses. Read more.
Prof. Rohde has also published two nCoV articles with the American Society for Microbiology (ASM):
- 2019 Novel Coronavirus (2019-nCoV) Update: Uncoating the Virus
- Novel Coronavirus Lab Protocols and Responses: Next Steps
Interactive map: global disease outbreak experts
The map represents the most active institutions researching disease outbreak and control. We ran a search in Scopus — a source-neutral abstract and citation database of over 75 million records — for publications researching the coronavirus and related diseases such as SARS from 1996 to the present (Feb 6, 2020). We then used the resulting ~22,000 publications to identify the researchers and institutions that are working in these areas. The map shows the 500 most prolific global institutions, along with the 200 most prolific Chinese institutions by publication count.
Click on a pin to see more about the institution, the numbers of researchers and their publications. Then link through to the researcher's profiles in Scopus to learn more about their areas of expertise.
Video: Novel Coronavirus Update
Livestreamed on Feb 6, 2020
JAMA Editor-in-Chief Howard Baucher, MD, interviews Anthony Fauci, MD, Director of the NIH National Institute of Allergy and Infectious Diseases.
Key facts for clinicians
By Margaret Trexler Hessen, MD | Updated Feb 3, 2020
Background: In December, China notified the World Health Organization of several cases of human respiratory illness, which appeared to be linked to an open seafood and livestock market in the city of Wuhan. The infecting agent has since been identified as a novel coronavirus, now called 2019-nCoV. Although the virus is presumed zoonotic in origin, person-to-person spread is evident. Cases have now been reported in many part of mainland China and in other countries in Asia, Europe, the eastern Mediterranean, Australia, Asia Pacific and North America. Travel within China has been restricted travel to and from China markedly reduced. Screening of travelers is being implemented in other countries and quarantine measures have been enacted under some circumstances. Despite these precautions, it is anticipated that more cases will be seen both inside China and internationally.
Novel coronaviruses have emerged as human pathogens in the past, notably associated with outbreaks of SARS (severe acute respiratory syndrome) and MERS (Middle East respiratory syndrome). Current investigative methods and recommendations derive in some part from the experience of those epidemics.
Clinical presentation: The incubation period is thought to be 2 to 14 days. Symptoms include fever (which may be absent in persons at extremes of age or with immunocompromise), cough and dyspnea. Chest radiographs may show bilateral infiltrates. Clinical illness varies from mild to severe; about 25% of confirmed cases have been classified as severe, and there are increasing numbers of deaths. In early cases, mortality was associated with advanced age or comorbidities.
Diagnosis: Although respiratory infections (including influenza) are prevalent in the northern hemisphere during the winter, clinicians should inquire about travel history in persons presenting with respiratory illness. The possibility of 2019-nCoV infection should be suspected in persons who present with compatible clinical illness and exposure history. The US Centers for Disease Control (CDC) and World Health Organization (WHO) have slightly different criteria for whom to test, as noted below:
- Recent travel (within 14 days) from Wuhan, Hubei Province, China (WHO). The CDC has broadened geographic criteria to include travel from Hubei Province — and for persons with fever and lower respiratory illness requiring hospitalization, travel from mainland China.
- Close contact with a person suspected or known to have infection due to 2019-nCoV (WHO, CDC). The CDC defines close contact as being within 6 feet (2 meters) or within a room or care area for a prolonged period without personal protective equipment OR having direct contact with secretions of a person with 2019-nCoV infection.
- Exposure to a healthcare facility in a country where hospital-associated nCoV infections have been reported (WHO).
- The disease occurs in a healthcare worker who has been working in an environment where patients with severe acute respiratory infections are being cared for, without regard to place of residence or history of travel (WHO).
- The person develops an unusual or unexpected clinical course, especially sudden deterioration despite appropriate treatment, without regard to place of residence or history of travel, even if another etiology has been identified that fully explains the clinical presentation (WHO).
- In Hubei province only, a trained medical professional can now classify a suspected case of COVID19 as a clinically-confirmed case on the basis of chest imaging, rather than a laboratory confirmation (WHO, as of 13 Feb 2020)
In the United States, suspected cases should be reported immediately to local or state health departments, which will determine whether the patient meets clinical and epidemiologic criteria for disease and coordinate diagnostic testing of suspected patients through the CDC. Collection of specimens from the upper respiratory tract, lower respiratory tract and serum is recommended as a priority; other specimens, such as stool or urine, may be collected and stored to be tested at the discretion of the CDC. The CDC provides detailed information on collection and shipping of specimens for cases approved by local or state authorities. The CDC advises that testing for other respiratory pathogens by the provider should be done as part of the initial evaluation and should not delay specimen shipping to CDC.
If a patient with suspected 2019-nCoV infection tests positive for another respiratory pathogen, after clinical evaluation and consultation with public health authorities, they may no longer be considered a person under investigation.
Management: No specific antiviral agent is available for treatment of this infection, and there is no vaccine. Treatment is supportive and includes supplemental oxygen and conservative fluid management, as indicated by clinical condition. WHO provides detailed guidance on such supportive measures and cautions that severely ill patients should be treated empirically for other possible causes while diagnostic test results are pending.
Infection control measures are an integral part of management:
- Provide the patient with a face mask and place the patient in a closed room (preferably with structural safeguards against airborne transmission).
- Persons entering the room should follow standard, contact, and airborne precautions.
- Patients managed at home are encouraged to self-isolate to a single area of the house (preferably with a separate bathroom) and to wear a face mask during any contact with household members.
- The patient and all household members should follow diligent hand and cough hygiene.
Complications: Respiratory failure and septic shock occur in some patients. The case fatality rate is about 2 percent.
Margaret Trexler Hessen, MD, is an infectious disease specialist with 20 years of clinical practice experience and public health service, including outbreak management. She has been with Elsevier since 2010 and is currently Director, Point of Care.
Clinicians need reliable and current information to combat novel coronavirus
By Jonathan Temte, MD, PhD | January 27, 2020
Coronaviruses are incredibly diverse, found in many animal species, and are commonly encountered in clinical practice during the cold and flu season, yet many primary care clinicians are not familiar with these respiratory pathogens. We rarely test for them, and when we do it’s usually when we’re looking for something else. Moreover, we have no specific treatments for these viruses.
The usual suspects have funny names: coronavirus HKU1, NL63, 229E and OC43. In our ongoing surveillance and epidemiological studies in school, clinics and longterm care settings, we find all four of these. There are two other coronaviruses that have been previously shown to infect humans: SARS (severe acute respiratory syndrome-associated coronavirus, or SARS-CoV), which emerged in 2003, and MERS (Middle East Respiratory Syndrome Coronavirus, or MERS-CoV), which emerged in 2012. SARS and MERS are associated with high case fatality rates.
Now a novel coronavirus, named 2019-nCoV, has emerged in China. There are hundreds of cases in China and multiple cases across the globe. The second case in the US was confirmed Friday in Illinois. We are extremely early in this rapidly expanding outbreak. With this evolving situation comes fear, misinformation and many unknowns. Accordingly, clinicians need to find reliable and current sources of credible information. A good place to start is the CDC resource page for healthcare professionals.
Jonathan Temte, MD, PhD, is Associate Dean for Public Health and Community Engagement and Professor of Family Medicine and Community Health at the University of Wisconsin School of Medicine and Public Health and former Chair of the Advisory Committee on Immunization Practices (ACIP). Jon currently serves as Chair of the Wisconsin Council on Immunization Practices and has been active on pandemic influenza and bioterrorism working groups for the state. He is a consultant for Elsevier's PracticeUpdate.
Elsevier Clinical Solutions
We've selected content from ClinicalKey, Clinical Solutions Nursing, Interprofessional Practice and Patient Education collections to share what we know to date about the novel coronavirus.
Clinical Overviews on ClinicalKey
Clinical Overviews are easy-to-scan clinically focused medical topic summaries designed to match the clinician workflow. Elsevier's Point-of-Care Editorial team develops Clinical Overviews through a process that includes review and revision by a medical editor; peer reviews performed by subject matter experts; a production review to ensure consistency in style, grammar, and punctuation; and a final evaluation by the editor-in-chief.
Clinical Skills for Nursing
Clinical Skills for Nursing provides the highest quality evidence for nursing practice procedures for nurses to care for patients. Our Isolation Precautions and Personal Protective Equipment checklists align with CDC and OSHA guidelines:
- Skills checklist “Isolation Precautions and Personal Protective Equipment”
- Extended text: “Isolation Precautions: Personal Protective Equipment”
- FAQ based the recommendations made by the CDC and WHO for nurses and patients
Interprofessional Care Plans
These Interprofessional Care Plans provide an evidence-based and individualizable Interprofessional plan of care to manage fever and the possible development of pneumonia, which is consistent with the presentation of this virus. Using an interprofessional approach to patient care that aligns current evidence with the individual needs of the patient results in improved patient care outcomes.
- Care Plan Guide: Fever — Adult
- Care Plan Guide: Fever — Pediatric
- Care Plan Guide: Pneumonia — Adult
- Care Plan Guide: Pneumonia — Pediatric
Patient engagement resources
Patient engagement resources use plain language to support shared decision-making between patients and healthcare providers. The goal is to deliver the right message in the right way at the time the patient is most ready to learn. The following resources provide an overview of the novel coronavirus to help patients and their families understand their risk, identify signs and symptoms, and prevent it from spreading:
Video overview of Coronavirus from 3D4Medical - Watch now:
中文资源 (Chinese-language resources)
|Title||Published by (CN)||Published by (EN)||Link|
|2019新型冠状病毒信息库||National Genomics Data Center|
National Microbiological Data Center;|
National Pathogen Resource Collection Center
|Diagnosis & Treatment Guidelines|
|新型冠状病毒感染的肺炎诊疗方案（试行第三版）（PDF可下载）||国家卫生健康委员会||National Health Commission||http://www.nhc.gov.cn/yzygj/s7653p/202001/f492c9153ea9437bb587ce2ffcbee1fa.shtml|
|湖北省新型冠状病毒感染的肺炎诊疗方案(试行第一版）||湖北省医疗救治专家组||Medical Expert Panel of Hubei Province||https://xw.qq.com/cmsid/20200123A0KNOW00|
|《新型冠状病毒肺炎诊疗快速指南》||华中科技大学同济医学院附属同济医院专家组||Tongji Hospital, Tongji Medical College of HUST||https://xw.qq.com/health/20200124010910/HLH2020012401091000|
|《武汉协和医院处置2019新型冠状病毒感染策略及说明》||华中科技大学同济医学院附属协和医院专家组||Xiehe Hospital, Tongji Medical College of HUST||https://www.dxy.cn/bbs/newweb/pc/post/42662254|
|关于“新型冠状病毒感染的肺炎”诊疗建议方案（V2.0）||中国医学科学院北京协和医院||Peking Union Medical College Hospital, CAMS||https://new.qq.com/omn/HLH20200/HLH2020012501009300.html|
|医疗机构内新型冠状病毒感染预防与控制技术指南（第一版）||国家卫生健康委员会||National Health Commission|
|新型冠状病毒实验室生物安全指南（第二版）||国家卫生健康委员会||National Health Commission|
|新型冠状病毒感染的肺炎诊疗方案（试行第四版）||国家卫生健康委员会||National Health Commission|
|新型冠状病毒感染的肺炎防控方案（第三版）||国家卫生健康委员会||National Health Commission|
|新型冠状病毒感染的肺炎病例转运工作方案（试行）||国家卫生健康委员会||National Health Commission||http://www.nhc.gov.cn/xcs/zhengcwj/202001/ccee6ec0942a42a18df8e5ce6329b6f5.shtml|
|新型冠状病毒感染的肺炎患者遗体处置工作指引（试行）||国家卫生健康委员会||National Health Commission||http://www.nhc.gov.cn/yzygj/s7659/202002/163c26a24057489dbf64dba359c59a5f.shtml|
|新型冠状病毒感染的肺炎疫情分布||中国疾病预防控制中心||Chinese Center for Disease Control and Prevention|
|Research articles and book chapters|
|Notes from the Field: An Outbreak of NCIP (2019-nCoV) Infection in China — Wuhan, Hubei Province...[2020-01-22]||中国疾病预防控制中心||Chinese Center for Disease Control and Prevention||http://weekly.chinacdc.cn/en/article/id/e3c63ca9-dedb-4fb6-9c1c-d057adb77b57|
|A Novel Coronavirus Genome Identified in a Cluster of Pneumonia Cases — Wuhan, China 2019-2020[2020-01-21]||中国疾病预防控制中心||Chinese Center for Disease Control and Prevention||http://weekly.chinacdc.cn/en/article/id/a3907201-f64f-4154-a19e-4253b453d10c|
|中国新型冠状病毒感染病例首批临床数据报告（解读,||The Lancet Weichat Official Account||The Lancet Weichat Official Account||https://marlin-prod.literatumonline.com/pb-assets/Lancet/marketing/wechat/WeChat_website.jpg|
|引自《默里及纳达尔呼吸医学》，V Courtney Broaddus 主编，李为民、程德云主译，人民卫生出版社，2018||李为民、程德云主译，人民卫生出版社，2018||Elsevier, with content quoted from translation published by PMPH|
|轻症疑似2019新型冠状病毒患者及密切接触人员如何进行自我管理||北京协和医院呼吸科||Respiratory Department, Peking Union Medical College Hospital, CAMS||http://m.sohu.com/a/368777653_102327|
|《新型冠状病毒感染防护》||Elsevier Clinical Solutions||新型冠状病毒感染防护》|
|Institutional Special Reports|
|国家卫生健康委员会新型冠状病毒感染的肺炎专题||国家卫生健康委员会||National Health Commission||http://www.nhc.gov.cn/xcs/xxgzbd/gzbd_index.shtml|
|中国疾病预防控制中心新型冠状病毒感染的肺炎专题||中国疾病预防控制中心||Chinese Center for Disease Control and Prevention||http://www.chinacdc.cn/jkzt/crb/zl/szkb_11803/|
|中国疾病预防控制中心周报（English Version）||中国疾病预防控制中心||Chinese Center for Disease Control and Prevention||http://weekly.chinacdc.cn/|
|Key Media Special Reports|
|抗击肺炎专题||今日头条||Beijing Byte Dance Technology Co., Ltd.||https://www.toutiao.com/|
|#我在疫情第一线#||三联生活周刊||Sanlian Life Weekly||https://s.weibo.com/weibo?q=%23%E6%88%91%E5%9C%A8%E7%96%AB%E6%83%85%E4%B8%80%E7%BA%BF%23&from=default|
Video overview (Chinese language voice over)
In this section, you can find the following resources:
- Journal articles, including The Lancet Coronavirus hub
- Book chapters
- Early-stage research (preprints on SSRN)
- Resources for drug discovery
The Lancet Coronavirus hub
To assist health workers and researchers working under difficult and dangerous conditions to bring this outbreak to a close, The Lancet has created a Coronavirus hub page. This hub brings together new coronavirus content from The Lancet journals as it is published.
You can also find related information from Cell Press here
Content hubs from other publishers
Elsevier is among various publishers who are making relevant papers freely available. Others include: Springer Nature | Wiley | NEJM | BMJ | American Society for Microbiology | Chongqing VIP Information
Many publishers have also signed the Wellcome Trust Statement committing to share relevant nCoV research and data rapidly and openly.
Articles in Elsevier journals
Below are a selection of articles curated by our clinical solutions team and directly relevant to Novel Coronavirus (2019-nCov).
In addition to these, Elsevier has made more than 2,500 coronavirus-related articles freely available for the next six months (commencing 10/02/2019). You can find these articles here.
We will be updating this section continually.
- Novel coronavirus: From discovery to clinical diagnostics, Opinion, Infection, Genetics and Evolution (April 2020)
- Full-genome evolutionary analysis of the novel corona virus (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombination event, Short communication, Infection, Genetics and Evolution (April 2020)
- The Middle East Respiratory Syndrome (MERS), Infectious Disease Clinics of North America (Dec 2019)
- Severe Acute Respiratory Syndrome: Historical, Epidemiologic, and Clinical Features, Infectious Disease Clinics of North America (Dec 2019)
- Human Mobility and the Global Spread of Infectious Diseases: A Focus on Air Travel, Trends in Parisitology (Sept 2018)
- Biothreat Agents and Emerging Infectious Disease in the Emergency Department, Emergency Medicine Clinics of North America (May 2019)
- Emerging Respiratory Viruses in Children, Infectious Disease Clinics of North America (March 2018)
- Betacoronavirus Adaptation to Humans Involved Progressive Loss of Hemagglutinin-Esterase Lectin Activity, Cell Host & Microbe (March 2017)
- Epidemic and Emerging Coronaviruses (Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome), Clinics in Chest Medicine (March 2017)
- The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health — The latest 2019 novel coronavirus outbreak in Wuhan, China, International Journal of Infectious Diseases (Feb 2020)
- Cross-sectional investigation and risk factor analysis of community-acquired and hospital-associated canine viral infectious respiratory disease complex, Heliyon (Nov 2019)
- Chiral zirconium quantum dots: A new class of nanocrystals for optical detection of coronavirus, Heliyon (Aug 2018)
- MERS-CoV as an emerging respiratory illness: A review of prevention methods, Travel Medicine and Infectious Disease (January 2020)
- The association between domestic train transportation and novel coronavirus (2019-nCoV) outbreak in China from 2019 to 2020: A data-driven correlational report, Travel Medicine and Infectious Disease (January 2020)
- The next big threat to global health? 2019 novel coronavirus (2019-nCoV): What advice can we give to travellers? – Interim recommendations January 2020, from the Latin-American society for Travel Medicine (SLAMVI) Travel Medicine and Infectious Disease (January 2020)
- SARS-CoV, MERS-CoV and now the 2019-novel CoV: Have we investigated enough about coronaviruses? – A bibliometric analysis, Travel Medicine and Infectious Disease (January 2020)
- Prospect and application of Internet of Things technology for prevention of SARIs, Clinical eHealth (February 2020)
- Middle East Respiratory Syndrome Coronavirus: What Do We Know?, The Journal for Nurse Practitioners (Jan 2015)
More published research
- Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China, JAMA Network (Feb 7, 2020)
- Emerging Coronavirus 2019-nCoV Pneumonia, Radiology (Feb 6, 2020)
- Diagnosis and treatment recommendations for pediatric respiratory infection caused by the 2019 novel coronavirus, World Journal of Pediatrics (Feb 5, 2020)
- Imaging changes in patients with 2019-nCov, European Radiology (Feb 5, 2020)
- Novel coronavirus infection during the 2019-2020 epidemic: preparing intensive care units-the experience in Sichuan Province, China, Intensive Care Medicine (Feb 5, 2020)
- History is repeating itself: Probable zoonotic spillover as the cause of the 2019 novel Coronavirus Epidemic, Editorial, Le Infezioni in Medicina (March 5, 2020)
- Note from the editors: World Health Organization declares novel coronavirus (2019-nCoV) sixth public health emergency of international concern, Editorial, Eurosurveillance (Feb 6, 2020)
- 2019 Novel Coronavirus—Important Information for Clinicians, Viewpoint, JAMA Network (Feb 5, 2020)
- Chest CT Findings in 2019 Novel Coronavirus (2019-nCoV) Infections from Wuhan, China: Key Points for the Radiologist, Reviews and Commentary Editorial, Radiology (Feb 4, 2020)
- CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV), Case Series, Radiology (Feb 4, 2020)
- A pneumonia outbreak associated with a new coronavirus of probable bat origin, unedited manuscript, Nature (Feb 3, 2020)
- First Case of 2019 Novel Coronavirus in the United States, The New England Journal of Medicine (Jan 31, 2020)
- Vincent J. Munster, PhD, et al: A Novel Coronavirus Emerging in China — Key Questions for Impact Assessment, The New England Journal of Medicine (Jan 24, 2020)
- Na Zhu, PhD, et al: A Novel Coronavirus from Patients with Pneumonia in China, 2019, The New England Journal of Medicine (Jan 24, 2020)
- Stanley Perlman, MD, PhD: Another Decade, Another Coronavirus, The New England Journal of Medicine (Jan 24, 2020)
- Catharine I. Paules, MD; Hilary D. Marston, MD, MPH; Anthony S. Fauci, MD: Coronavirus Infections — More Than Just the Common Cold – JAMA Viewpoint, JAMA Network (Jan 2020)\
- Novel Coronavirus from Wuhan China, 2019-20, Update to Chapter 155, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, Ninth Edition (Elsevier, 2020)
- Coronaviruses, Including Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS), Chapter 155, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases, Ninth Edition (Elsevier, 2020)
- Viral Infections, Chapter 32, Murray and Nadel’s Textbook of Respiratory Medicine, Sixth Edition (Elsevier, 2016)
- Coronaviruses, Chapter 31, Fenner and White's Medical Virology (Fifth Edition (Elsevier's Academic Press, 2017)
Early-stage research (preprints on SSRN platform)
Emerging and rapidly evolving healthcare emergencies necessitate the quick dissemination of research. The growing role of preprints, or early-stage research, was acknowledged in the Ebola and Zika virus outbreaks as a way of “accelerating the dissemination of scientific findings to support responses to infectious disease outbreaks.”
SSRN, Elsevier’s world-leading platform devoted to the rapid worldwide dissemination of early-stage research, is committed to making authors' coronavirus related research available immediately. Research on SSRN is free to download and upload. It is important to note that these papers have not benefited from the pivotal role of the peer-review process, which validates and improves the quality of final published journal articles.
- The Psychological Impact of Quarantine and How to Reduce It: Rapid Review of the Evidence, Preprints with The Lancet (Feb 6, 2020)
- Clinical Features of 2019 Novel Coronavirus Pneumonia Presented Gastrointestinal Symptoms But Without Fever Onset, Preprints with The Lancet (Feb 6, 2020)
- Transmission Dynamics of 2019 Novel Coronavirus (2019-nCoV), Preprints with The Lancet (Feb 5, 2020)
- Understanding Unreported Cases in the 2019-Ncov Epidemic Outbreak in Wuhan, China, and the Importance of Major Public Health Interventions, Preprints with The Lancet (Feb 4, 2020)
- Epidemic Prediction of 2019-nCoV in Hubei Province and Comparison with SARS in Guangdong Province, Preprints with The Lancet (Feb 4, 2020)
- An Evidence-Based Framework for Priority Clinical Research Questions for 2019-nCoV, Preprints with The Lancet (Feb 4, 2020)
- The Epidemic Dynamics of 2019 Novel Coronavirus (2019-nCoV) Infections in China by 28 January, Preprints with The Lancet (Feb 4, 2020)
- Estimating the Number of 2019 Novel Coronavirus Cases in Chinese Mainland, Preprints with The Lancet (Feb 4, 2020)
- From SARS-CoV to Wuhan 2019-nCoV Outbreak: Similarity of Early Epidemic and Prediction of Future Trends, Cell Press Sneak Peak (Jan 31, 2020)
- Cell Pyroptosis, a Potential Pathogenic Mechanism of 2019-nCoV Infection (Jan 29, 2020)
- Estimation of the Transmission Risk of 2019-nCov and Its Implication for Public Health Interventions (Jan 27, 2020)
- Early transmissibility assessment of a novel coronavirus in Wuhan, China (Jan 27, 2020)
- Epidemiological and Clinical Characteristics of 99 Cases of 2019-Novel Coronavirus (2019-nCoV) Pneumonia in Wuhan, China, Preprints with The Lancet (Jan 27, 2020)
- Clinical Characteristics and Vertical Transmission Potential of 2019-nCoV Infection in Patients with Pregnancy, Preprints with The Lancet (Feb 11, 2020)
- Clinical Features and Computed Tomographic Manifestations of Patients with 2019 Novel Coronavirus Pneumonia: A Single Center Study in Shanghai, China, Preprints with The Lancet (Feb 11, 2020)
- Early in the Epidemic: Impact of Preprints on Global Discourse of 2019-nCOV Transmissibility (Feb 12, 2020)
- Nowcasting and Forecasting the Spreading of Novel Coronavirus 2019-nCoV and Its Association with Weather Variables in 30 Chinese Provinces: A Case Study, Preprints with The Lancet (Feb 13, 2020)
- The Evolution of Quarantined and Suspected Cases Determines the Final Trend of the 2019-nCoV Epidemics Based on Multi-Source Data Analyses, Preprints with The Lancet, (Feb 13,2020)
- Novel Coronavirus (2019-nCoV) Outbreak; A Systematic Review for Published Papers, Preprints with The Lancet (Feb 13, 2020)
- Review of Health Security Capacities in Light of 2019-nCoV Outbreak – Opportunities for Strengthening IHR (2005) Implementation, Preprints with The Lancet (Feb 13, 2020)
- Simulating the Infected Population and Spread Trend of 2019-nCov Under Different Policy by EIR Model, Preprints with The Lancet, (Feb 13 2020)
- Correlation Analysis of the Population Emigration Rate in Wuhan and the Trend of Novel Pneumonia in Hubei Province, Preprints with The Lancet, (Feb 13 2020)
- The Epidemiological and Clinical Characteristics of 2019 Novel Coronavirus Infection in Changsha, China, Preprints with The Lancet (Feb 13 2020)
Resources for drug discovery
Elsevier's R&D solutions for pharma and life sciences integrate data, analytics and technology to help researchers make data-driven drug discovery and development decisions and streamline literature monitoring for pharmacovigilance. Here, we will use those tools to generate information relevant to combatting 2019-nCoV.
- 121 drugs and natural products successfully used against previous coronavirus infections including SARS. This list was generated using Elsevier's Pathway Studio.
- 393 substances that interact with 25 targets related to 6 target species including SARS coronavirus, Middle East respiratory syndrome coronavirus, human Middle East respiratory syndrome coronavirus, Human coronavirus 229E, Coronaviridae and Coronavirinae, with normalized affinity value > 6. This list was generated using Elsevier’s Reaxys Medicinal Chemistry.
- Autophagy is a cellular recycling process, whereby cells eliminate damaged or diseased components in order to regenerate and build new healthier cells; thus, viruses are usually identified and disposed of in this way. Would it be possible to induce the autophagy process and limit the viral infection by using some substances? Pathway Studio provides a list of 406 compounds that have been reported inhibiting autophagy pathway, and their related references.
- Interactive map shows global spread of the virus (Johns Hopkins CSSE)
- Guidance for businesses and employers (CDC)
- Infection prevention and control for the care of patients with nCoV in healthcare settings (European CDC)
- Flowchart to Identify and Assess 2019 Novel Coronavirus (CDC)
- Travel precautions (CDC)
- Information and updates (CDC)
- Guidance for healthcare professionals (CDC)
- Information for Laboratories (CDC)
- Novel coronavirus advice for the public (WHO)
- Clinical management of severe acute respiratory infection when Novel coronavirus (nCoV) infection is suspected: Interim Guidance (WHO)
- WHO: Statement on the meeting of the IHR (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV)
- National Genomic Data Center (China) 2019 nCoV Resource Center (新型冠状病毒信息库)
Official coronavirus guidance from various countries:
- Sources of updated information in the EU/EEA countries
- Panamerican Health Organization (Latin American branch of the WHO)
In the media
- Coronavirus concerns trigger global run on supplies for health workers, causing shortages, STAT (Feb 7, 2020)
- Bill & Melinda Gates Foundation will commit up to $100 million for novel coronavirus response (Feb 5, 2020)
- US expands use of covonavirus diagnostic test, FDA (Feb 4, 2020)
- WHO declares coronavirus outbreak a global health emergency, STAT (Jan 30, 2020)
- Coronavirus Hits China Exchange Programs, Inside Higher Ed (Jan 29, 2020) Following CDC guidance, colleges are suspending travel to China, a popular destination for faculty and students and a country where many colleges have deep connections.