The Theory of Endobiogeny

The Theory of Endobiogeny

Volume 1: Global Systems Thinking and Biological Modeling for Clinical Medicine

1st Edition - June 18, 2019

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  • Authors: Kamyar M. Hedayat, Jean-Claude Lapraz
  • Paperback ISBN: 9780128169032
  • eBook ISBN: 9780128173268

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The Theory of Endobiogeny Volume 1: Global Systems Thinking and Biological Modeling for Clinical Medicine offers researchers and clinicians a detailed introduction to the theory of Endobiogeny. The book presents a new approach to medicine that is at once scientific and humanistic, quantitative, and qualitative. The philosophical and experimental basis of a global complex systems approach to physiology is presented along with a mathematical approach to modeling the dynamism of the terrain. The importance of the history and physical examination are renewed as a source of “big data” readily available to clinicians for greater insight into the patient’s state. Expansion of the therapeutic compendium is proposed based on a rational, clinical approach correlated to mathematical indicators of the physiologic state. What is proposed in this work is a fundamental shift in scientific thinking with a resulting expansion of the boundaries of clinical medicine for the 21st century and beyond.

Key Features

  • Extends systems biology from the cellular to the integrative physiologic level
  • Moves the functional medicine approach to a higher level of integration and true global systems thinking
  • Presents mathematical tools and proofs of formulas related to the biology of functions: a biological modeling system based on the theory of endobiogeny. The biology of functions has assisted clinicians in conceptualizing, treating, and objectively monitoring the longitudinal effects of treatment through the evolution of the patient’s unique phenotypic expression of terrain


Researchers and clinicians interested in systems biology and integrative medicine

Table of Contents

  • 1. Origins of endobiogeny
    2. A general overview of systems theory, integrative physiology, and the theory of endobiogeny
    3. The autonomic nervous system
    4. A clinical introduction to the endocrine system according to the theory of endobiogeny
    5. The pineal axel
    6. The corticotropic axis
    7. Gonadotropic axis
    8. Thyrotropic axis
    9. Somatotropic axis
    10. Endocrine associations: Coupling, linking, and yoking
    11. Endocrine-organ relationships: Drainage, detoxification, and disease
    12. Adaptation syndromes
    13. Art of history taking in endobiogeny
    14. Art of physical examination in endobiogeny
    15. A new approach to biological modeling: Introduction to the biology of functions
    16. Introduction to the usage of medicinal plants
    17. Therapeutics according to an endobiogenic reflection

Product details

  • No. of pages: 306
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: June 18, 2019
  • Imprint: Academic Press
  • Paperback ISBN: 9780128169032
  • eBook ISBN: 9780128173268

About the Authors

Kamyar M. Hedayat

Kamyar M Hedayat is a global leader in research and training in Endobiogeny and protégé of Dr. Lapraz. A Stanford-trained critical care physician, he has been practicing endobiogenic medicine since 2008. Drs. Hedayat and Lapraz are cofounders of the American Society of Endobiogenic Medicine and Integrative Physiology and copresidents of the Systems Biology Research Group.

Affiliations and Expertise

Founder and Director, Full Spectrum Health Center, Chicago, Illnois, USA

Jean-Claude Lapraz

Jean-Claude Lapraz is a global leader in research and training in Endobiogeny since 1983. Trained in medicine at Paris Descartes University, he is codeveloper of the original teachings of Endobiogeny along with its inventor, Dr. Christian Duraffourd (1943–2017). He has practiced terrain-based medicine since 1972 and Endobiogeny from its inception.

Affiliations and Expertise

General Practitioner, Private Practice, Paris, France

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  • Adam J. Thu Sep 12 2019


    This is the most elegant approach to clinical medicine that I have encountered in my 15 years of practice. By comparison, I feel like my classically trained practice of medicine is vulgar and unenlightened. This book is modern, academic, and beautifully articulated. This is the combined work of genius-level intelligence.

  • Thomas S. Tue Jul 02 2019

    a true scientific book presenting endobiogenic medicine

    Here is finally a true scientific work of high level presenting the Endobiogenic medicine. This book is clear, precise, extremely well documented and referenced written by two known and recognized scientists in the field of integrative medicine. It allows to understand this system theory and to discover the complexity of the "Biology of Functions": analysis tool obtained through algorithms based on physiology data, allowing a quantified evaluation of the state of the metabolic terrain of the subject from biomarkers. I recommend this book to all scientists and health practitioners.