Redox Chemistry and Biology of Thiols

1st Edition - May 25, 2022
Editors: Beatriz Alvarez, Marcelo Comini, Gustavo Salinas, Madia Trujillo
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 0 2 1 9 - 9
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 1 5 6 6 - 3

Redox Chemistry and Biology of Thiols offers an applied, comprehensive overview of redox chemistry and biology of thiol-dependent processes. Running from basic biology and chemi… Read more

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Redox Chemistry and Biology of Thiols offers an applied, comprehensive overview of redox chemistry and biology of thiol-dependent processes. Running from basic biology and chemistry of redox phenomena to research methods and highlighting recently identified roles of thiols across cellular and bodily systems, this book draws upon a range of disciplines to illuminate new research directions, new applications of thiol studies, and clinical translation. Sections cover thiol oxidizing species, thiol reactivity and modifications, thioredoxin, glutaredoxin, glutathione, peroxidases, thiol repair enzymes, thiol oxidative signaling, disulfide bond formation, thiol-based redox biosensors, cysteine and hydrogen sulfide metabolism, iron-sulfur cluster biogenesis, thiols in chloroplasts, blood thiols, sugar and polyamine thiols in pathogenic organisms, redox medicine (therapeutic applications of thiols and drug development), as well as methods and bioinformatics tools.

1. Basic concepts of thiol chemistry and biology
Beatriz Alvarez (Universidad de la República, Uruguay) and Gustavo Salinas (Universidad de la República and Institut Pasteur of Montevideo, Uruguay)

2. Chemical basis of cysteine reactivity: Acidity and nucleophilicity
Gerardo Ferrer-Sueta (Universidad de la República, Uruguay)

3. Computational functional analysis of cysteine residues in proteins
Stefano M. Marino (International School of Verona, Italy), Gustavo Salinas (Universidad de la República and Institut Pasteur of Montevideo, Uruguay) and Vadim Gladyshev (Harvard Medical School, USA)

4. Global approaches for protein thiol redox state detection and quantification
Lars I. Leichert (Ruhr University Bochum, Germany)

5. Thiol oxidation by biologically-relevant reactive species
Ari Zeida and Rafael Radi (Universidad de la República, Uruguay)

6. Thiyl radicals: formation, properties and detection
Christian Schöneich (The University of Kansas, USA)

7. Detection of the oxidation products of thiols: disulfides, sulfenic, sulfinic and sulfonic acids
Yunlong Shi and Kate S. Carroll (Scripps Research Institute, USA)

8. Biochemistry and detection of S-nitrosothiols
Matías Moller and Ana Denicola (Universidad de la República, Uruguay)

9. Thiol modification and signaling by biological electrophiles
Francisco J. Schopfer and Darío A. Vitturi (University of Pittsburgh, USA)

10. Thioredoxin and glutathione reductases
Elias S.J. Arnér (Karolinska Institutet, Sweden)

11. Functional plasticity in the thioredoxin family: FeS-thio- and glutaredoxins
Carsten Berndt, Christina Wilms (Heinrich-Heine-Universität, Düsseldorf, Germany)
Yana Bodnar. Manuela Gellert and Christopher Lillig (University of Greifswald, Germany). In memory of Arne Holmgren

12. Glutathione and glutathione-dependent enzymes
Marcel Deponte (University of Kaiserslautern, Germany)

13. Thiol and selenol-based peroxidases: Structure and catalytic properties
Madia Trujillo (Universidad de la República, Uruguay), Carlos A. Tairum (Universidade de Sao Paulo, Brazil), Marcos Antonio de Oliveira (Universidade Estadual Paulista, Brazil) and Luis Eduardo Soares Netto (Universidade de Sao Paulo, Brazil)

14. Thiol peroxidase-based redox relays
Deepti Talwar and Tobias P. Dick (German Cancer Research Center and Heidelberg University, Germany)

15. Compartmentalized disulphide bond formation pathways
Konstantin Weiss, Julia Racho and Jan Riemer (University of Cologne, Germany)

16. Disulfide bond formation in Escherichia coli
Bruno Manta, Emily Lundstedt, Augusto Garcia James Eaglesham and Mehmet Berkmen (New England BioLabs, USA)

17. Thiol-based redox probes
Jannik Zimmermann and Bruce Morgan (Saarland University, Germany)

18. Selenocysteine-containing proteins
Marco Mariotti (Universitat de Barcelona, Spain) and Vadim Gladyshev (Harvard Medical School, USA)

19. Overview of cysteine metabolism
Sebastián Carballal (Universidad de la República, Uruguay) and Ruma Banerjee (University of Michigan, USA)

20. Hydrogen sulfide and persulfides
Ernesto Cuevasanta, Dayana Benchoam, Matías N. Möller, Sebastián Carballal (Universidad de la República, Uruguay), Ruma Banerjee (University of Michigan, USA) and Beatriz Alvarez (Universidad de la República, Uruguay)

21. The role of thiols in iron-sulfur cluster biogenesis
Tirthankar Bandyopadhyay and Caryn E. Outten (University of South Carolina, USA)

22. Thiol-based redox control in chloroplasts
Linda de Bont, Jean-Pierre Jacquot, Nicolas Rouhier (Université de Lorraine, France)

23. Sugar-based cysteine thiols recruited for oxidative stress defence and redox regulation
Daria Ezeriņa and Joris Messens (Vrije Universiteit Brussel, Belgium)

24. Polyamine-based thiols in pathogens
Marcelo Comini (Institut Pasteur of Montevideo, Uruguay)

25. Thiols in blood
Lucia Turell, Matías N. Möller, Florencia Orrico, Lía M. Randall, Martina Steglich, Sebastián Villar, Ana Denicola and Leonor Thomson (Universidad de la República, Uruguay)

26. A thiol chemistry perspective on redox medicine
Tom E. Forshaw, Allen W. Tsang and Cristina M. Furdui (Wake Forest School of Medicine, USA)

27. Therapeutic applications of low-molecular-weight thiols and selenocompounds
Pablo A. Nogara (Universidade Federal de Santa Maria, Brazil), Cláudia S. Oliveira Meire E. Pereira (Instituto de Pesquisa Pelé Pequeno Príncipe and Faculdades Pequeno Príncipe Curitiba, Brazil), Marco Bortoli, Laura Orian (Università degli Studi di Padova, Italy), Michael Aschner (Albert Einstein College of Medicine, NY-USA), and João B. T. Rocha (Universidade Federal de Santa Maria, Brazil)

28. Thiol targets in drug development to combat bacterial infections
Verena N. Fritsch and Haike Antelmann (Freie Universität Berlin, Germany)

Beatriz Alvarez

Dr. Beatriz Alvarez is a Professor at the Laboratory of Enzymology, School of Sciences, Universidad de la República, Montevideo, Uruguay. Her research interests span the areas of redox biochemistry, kinetics and enzymology, especially in relation to biological thiols and hydrogen sulfide.

Affiliations and expertise

Professor, Laboratory of Enzymology, School of Sciences, Universidad de la República, Montevideo, Uruguay

Marcelo Comini

Dr. Marcelo Comini is a Principal Investigator at the Redox Biology of Trypanosomes Laboratory, Institut Pasteur de Montevideo, Uruguay. He is a Biochemist (Universidad Nacional del Litoral, Argentina) and Dr. rer. nat. from the Technische Universität Brausnchweig (Germany). The research interest of his lab encompasses understanding the role of different components of the thiol-redox system of trypanosomatids, the identification of inhibitors thereof, and the development of fluorescent-protein redox biosensors.

Affiliations and expertise

Principal Investigator, Redox Biology of Trypanosomes Laboratory, Institut Pasteur de Montevideo, Uruguay

Gustavo Salinas

Dr. Gustavo Salinas is a Principal Investigator at the Worm Biology Laboratory, Institut Pasteur de Montevideo, Uruguay, as well as a Professor at the Department of Biosciences, School of Chemistry, Universidad de la República, Uruguay. His research contributes to the understanding of linked thioredoxin-glutathione systems in parasites, glutathione-independent deglutathionylation, selenocysteine horizontal gene transfer and the use of selenocysteine in fungi. He is also interested in anaerobic mitochondria and recently discovered key steps in the biosynthesis of rhodoquinone, an electron transporter used in anaerobic bioenergetics.

Affiliations and expertise

Principal Investigator, Worm Biology Laboratory, Institut Pasteur de Montevideo; Professor, Department of Biosciences, School of Chemistry, Universidad de la República, Uruguay

Madia Trujillo

Madia Trujillo, MD, PhD, is an Associate Professor of Biochemistry at the School of Medicine and an Investigator at the Centro de Investigaciones Biomédicas, Universidad de la República, Uruguay. Her research focuses on the characterization of the reactions of biologically relevant oxidants as well as in the mechanisms of their sensing and detoxification, particularly in humans and human pathogens.

Affiliations and expertise

Associate Professor, Biochemistry, School of Medicine; Investigator, Centro de Investigaciones Biomédicas, Universidad de la República, Uruguay