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1.2 A Historical Example
1.3 Anthology Architecture
2. Application of Plastics in Medical Devices and Equipment
2.1 Device Industry Overview
2.2 Health-care Trends
2.3 From Legacy Materials to Advanced Specialty Polymers for Devices
2.4 Driving Trends Leading to New Material Requirements
2.5 Market Factors Affecting the Industry
3. Plastics Used in Medical Devices
3.1 Plastic Compositions
3.2 Medical Devices—Material Selection Process
3.3 Common Medical Device Polymers
4. Polymeric Biomaterials
4.2 Polymeric Biomaterials in Ophthalmology
4.3 Polymeric Biomaterials in Orthopedics
4.4 Polymeric Biomaterials in Cardiovascular Diseases
4.5 Polymeric Biomaterials for Wound Closure
4.6 Polymeric Biomaterials in Extracorporeal Artificial Organs
4.7 Polymeric Biomaterials for Nerve Regeneration
4.8 Conclusions and Future Outlook
5. Biofilms, Biomaterials, and Device-Related Infections
5.2 Bacterial Biofilms
5.3 Biofilm Microbiology and Infectious Disease
5.4 Device-Related Infection
5.5 Clinical Examples of Biofilm Infections
5.6 Prevention and Treatment
6. Adhesives for Medical and Dental Applications
6.2 Natural Adhesives
6.3 Synthetic and Semisynthetic Adhesives
6.4 Cyanoacrylic Adhesives
6.5 Test Methods to Characterize Strength of Tissue Adhesives
6.6 Medical and Dental Applications of Adhesives
6.7 Bone Adhesives
6.8 Dental Applications of Adhesives
7.1 Chemical Structure and Nomenclature
8. Review of Research in Cardiovascular Devices
8.2 The Heart Diseases
8.3 The Cardiovascular Devices in Open-Heart Surgery
8.4 The Minimally Invasive Cardiology Tools
8.5 The Technology for Atrial Fibrillation
8.6 Minimally Invasive Surgery
8.7 The Minimally Invasive Valve Implantation
8.8 Support Technology for Surgery Planning
9. Endotracheal Tube and Respiratory Care
9.2 Properties of the Endotracheal Tube
9.3 Endotracheal Tubes and Other Airway Adjuncts
9.4 Proper Safeguarding of the Airway
9.5 Maintenance of the Endotracheal Tube
9.6 Respiratory Therapies for the Intubated Patient
9.8 Clinical Pearls
10. Applications of Polyaryletheretherketone in Spinal Implants: Fusion and Motion Preservation
10.2 Origins of Interbody Fusion and the “Cage Rage” of the Late 1990s
10.3 CFR-PEEK Lumbar Cages: The Brantigan Cage
10.4 Threaded PEEK Lumbar Fusion Cages
10.5 Clinical Diagnostic Imaging of PEEK Spinal Cages and Transpedicular Screws
10.6 Subsidence and Wear of PAEK Cages
10.7 Posterior Dynamic Stabilization Devices
10.8 Cervical and Lumbar Artificial Discs
11. Microbubble Applications in Biomedicine
11.2 Microbubbles for Ultrasound Imaging
11.3 Targeted Microbubbles
11.4 Microbubbles in Drug and Gene Delivery
11.5 Microbubbles in Gene Delivery
11.6 Other Emerging Applications
12. Hydrogels in Regenerative Medicine
12.1 Introduction: Relevance of Hydrogels to Regenerative Medicine
12.2 Background and Theory
12.3 Utility in Regenerative Medicine
12.4 Applications of Hydrogels in Regenerative Medicine
12.5 Prospects and Conclusions
13. Biodegradable Polymers
13.2 Biodegradable Polymer Selection Criteria
13.3 Biologically Derived Polymers
13.4 Synthetic Polymers
13.5 Combinations (Hybrids) of Synthetic and Biologically Derived Polymers
13.6 Using Polymers to Create Tissue-Engineered Products
14. Regulations for Medical Devices and Application to Plastics Suppliers: History and Overview
14.1 History and Introduction
14.2 United States Regulations
14.3 ISO 13485 (European and Global Standard)
14.4 Other Countries
14.5 Global Harmonization Task Force (GHTF)
14.6 Applicability of the Regulations to Material Suppliers
While the prevalence of plastics and elastomers in medical devices is now quite well known, there is less information available covering the use of medical devices and the applications of polymers beyond medical devices, such as in hydrogels, biopolymers and silicones beyond enhancement applications, and few books in which these are combined into a single reference.
This book is a comprehensive reference source, bringing together a number of key medical polymer topics in one place for a broad audience of engineers and scientists, especially those currently developing new medical devices or seeking more information about current and future applications. In addition to a broad range of applications, the book also covers clinical outcomes and complications arising from the use of the polymers in the body, giving engineers a vital insight into the real world implications of the devices they’re creating. Regulatory issues are also covered in detail. The book also presents the latest developments on the use of polymers in medicine and development of nano-scale devices.
- Gathers discussions of a large number of applications of polymers in medicine in one place
- Provides an insight into both the legal and clinical implications of device design
- Relevant to industry, academic and medical professionals
- Presents the latest developments in the field, including medical devices on a nano-scale
Engineers and Scientists involved in the design, manufacture, development, technical support and marketing of medical devices and materials used in medical device manufacture. Other professionals involved in the medical device industry or the clinical use of medical devices.
- No. of pages:
- © William Andrew 2014
- 6th December 2013
- William Andrew
- Hardcover ISBN:
- eBook ISBN:
Prof. Modjarrad is Adjunct Assistant Professor of Medicine at the Johns Hopkins University School of Medicine, Attending on infectious diseases consult service at the main hospital 1 month per year. Responsible for teaching residents and fellows. He was awarded with the following grants: 1. Vanderbilt Infection Pathogenesis and Epidemiology Research Training Program, $233,075, 2011-2012,
2. Vanderbilt International Office Exchange Grant, $15,000, 2008-2009.
3. EGPAF Research Grant (PG-51368), $280,000, 2003-2005.
4. U.S. Department of Defense, $15,000, 2003-2004.
5. National Institutes of Health, Fogarty International Research Collaborative Award (5R03TW005929-02), $100,000, 2002-2004.
He is the Co-Editor for the medical polymers series, beginning with the Handbook of Polymer Applications in Medicine and Medical Devices, first volume published in December 2013 (Williams Andrews).
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health
Sina Ebnesajjad is the series editor of Plastics Design Library (PDL) published in the William Andrew imprint of Elsevier. This Series is a unique series, comprising technology and applications handbooks, data books and practical guides tailored to the needs of practitioners. Sina was the editor-in-chief of William Andrew Publishing from 2005 to 2007, which was acquired by Elsevier in 2009.
He retired as a Senior Technology Associate in 2005 from the DuPont fluoropolymers after nearly 24 years of service. Sina founded of FluoroConsultants Group, LLC in 2006 where he continues to work. Sina earned his Bachelor of Science from the School of Engineering of the University of Tehran in 1976, Master of Science and PhD from the University of Michigan, Ann Arbor, all in Chemical Engineering.
He is author, editor and co-author of fifteen technical and data books including five handbooks on fluoropolymers technology and applications. He is author and co-author of three books in surface preparation and adhesion of materials, two of which are in their second editions. Sina has been involved with technical writing and publishing since 1974.
His experiences include fluoropolymer technologies (polytetrafluoroethylene and its copolymers) including polymerization, finishing, fabrication, product development, failure analysis, market development and technical service. Sina holds six patents.
Fluoroconsultants Group, Chadds Ford, PA, USA