Handbook of Polymer Applications in Medicine and Medical Devices

Handbook of Polymer Applications in Medicine and Medical Devices

1st Edition - December 5, 2013

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  • Editors: Kayvon Modjarrad, Sina Ebnesajjad
  • eBook ISBN: 9780323221696
  • Hardcover ISBN: 9780323228053

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While the prevalence of plastics and elastomers in medical devices is now quite well known, there is less information available covering the use of medical devices and the applications of polymers beyond medical devices, such as in hydrogels, biopolymers and silicones beyond enhancement applications, and few books in which these are combined into a single reference. This book is a comprehensive reference source, bringing together a number of key medical polymer topics in one place for a broad audience of engineers and scientists, especially those currently developing new medical devices or seeking more information about current and future applications. In addition to a broad range of applications, the book also covers clinical outcomes and complications arising from the use of the polymers in the body, giving engineers a vital insight into the real world implications of the devices they’re creating. Regulatory issues are also covered in detail. The book also presents the latest developments on the use of polymers in medicine and development of nano-scale devices.

Key Features

  • Gathers discussions of a large number of applications of polymers in medicine in one place
  • Provides an insight into both the legal and clinical implications of device design
  • Relevant to industry, academic and medical professionals
  • Presents the latest developments in the field, including medical devices on a nano-scale


Engineers and Scientists involved in the design, manufacture, development, technical support and marketing of medical devices and materials used in medical device manufacture. Other professionals involved in the medical device industry or the clinical use of medical devices.

Table of Contents

  • Preface

    Author Biographies

    1. Introduction

    1.1 History

    1.2 A Historical Example

    1.3 Anthology Architecture

    1.4 Summary


    2. Application of Plastics in Medical Devices and Equipment

    2.1 Device Industry Overview

    2.2 Health-care Trends

    2.3 From Legacy Materials to Advanced Specialty Polymers for Devices

    2.4 Driving Trends Leading to New Material Requirements

    2.5 Market Factors Affecting the Industry

    2.6 Conclusion

    3. Plastics Used in Medical Devices

    3.1 Plastic Compositions

    3.2 Medical Devices—Material Selection Process

    3.3 Common Medical Device Polymers

    3.4 Summary


    4. Polymeric Biomaterials

    4.1 Introduction

    4.2 Polymeric Biomaterials in Ophthalmology

    4.3 Polymeric Biomaterials in Orthopedics

    4.4 Polymeric Biomaterials in Cardiovascular Diseases

    4.5 Polymeric Biomaterials for Wound Closure

    4.6 Polymeric Biomaterials in Extracorporeal Artificial Organs

    4.7 Polymeric Biomaterials for Nerve Regeneration

    4.8 Conclusions and Future Outlook


    5. Biofilms, Biomaterials, and Device-Related Infections

    5.1 Introduction

    5.2 Bacterial Biofilms

    5.3 Biofilm Microbiology and Infectious Disease

    5.4 Device-Related Infection

    5.5 Clinical Examples of Biofilm Infections

    5.6 Prevention and Treatment

    5.7 Conclusions


    6. Adhesives for Medical and Dental Applications

    6.1 Introduction

    6.2 Natural Adhesives

    6.3 Synthetic and Semisynthetic Adhesives

    6.4 Cyanoacrylic Adhesives

    6.5 Test Methods to Characterize Strength of Tissue Adhesives

    6.6 Medical and Dental Applications of Adhesives

    6.7 Bone Adhesives

    6.8 Dental Applications of Adhesives


    7. Silicones

    7.1 Chemical Structure and Nomenclature

    7.2 Conclusion



    8. Review of Research in Cardiovascular Devices

    8.1 Introduction

    8.2 The Heart Diseases

    8.3 The Cardiovascular Devices in Open-Heart Surgery

    8.4 The Minimally Invasive Cardiology Tools

    8.5 The Technology for Atrial Fibrillation

    8.6 Minimally Invasive Surgery

    8.7 The Minimally Invasive Valve Implantation

    8.8 Support Technology for Surgery Planning

    8.9 Conclusions

    8.10 Acknowledgments


    9. Endotracheal Tube and Respiratory Care

    9.1 Introduction

    9.2 Properties of the Endotracheal Tube

    9.3 Endotracheal Tubes and Other Airway Adjuncts

    9.4 Proper Safeguarding of the Airway

    9.5 Maintenance of the Endotracheal Tube

    9.6 Respiratory Therapies for the Intubated Patient

    9.7 Conclusions

    9.8 Clinical Pearls


    10. Applications of Polyaryletheretherketone in Spinal Implants: Fusion and Motion Preservation

    10.1 Introduction

    10.2 Origins of Interbody Fusion and the “Cage Rage” of the Late 1990s

    10.3 CFR-PEEK Lumbar Cages: The Brantigan Cage

    10.4 Threaded PEEK Lumbar Fusion Cages

    10.5 Clinical Diagnostic Imaging of PEEK Spinal Cages and Transpedicular Screws

    10.6 Subsidence and Wear of PAEK Cages

    10.7 Posterior Dynamic Stabilization Devices

    10.8 Cervical and Lumbar Artificial Discs

    10.9 Summary



    11. Microbubble Applications in Biomedicine

    11.1 Introduction

    11.2 Microbubbles for Ultrasound Imaging

    11.3 Targeted Microbubbles

    11.4 Microbubbles in Drug and Gene Delivery

    11.5 Microbubbles in Gene Delivery

    11.6 Other Emerging Applications

    11.7 Conclusion


    12. Hydrogels in Regenerative Medicine

    12.1 Introduction: Relevance of Hydrogels to Regenerative Medicine

    12.2 Background and Theory

    12.3 Utility in Regenerative Medicine

    12.4 Applications of Hydrogels in Regenerative Medicine

    12.5 Prospects and Conclusions


    13. Biodegradable Polymers

    13.1 Introduction

    13.2 Biodegradable Polymer Selection Criteria

    13.3 Biologically Derived Polymers

    13.4 Synthetic Polymers

    13.5 Combinations (Hybrids) of Synthetic and Biologically Derived Polymers

    13.6 Using Polymers to Create Tissue-Engineered Products

    13.7 Conclusion


    14. Regulations for Medical Devices and Application to Plastics Suppliers: History and Overview

    14.1 History and Introduction

    14.2 United States Regulations

    14.3 ISO 13485 (European and Global Standard)

    14.4 Other Countries

    14.5 Global Harmonization Task Force (GHTF)

    14.6 Applicability of the Regulations to Material Suppliers

    14.7 Conclusion



Product details

  • No. of pages: 368
  • Language: English
  • Copyright: © William Andrew 2013
  • Published: December 5, 2013
  • Imprint: William Andrew
  • eBook ISBN: 9780323221696
  • Hardcover ISBN: 9780323228053

About the Editors

Kayvon Modjarrad

Prof. Modjarrad is Adjunct Assistant Professor of Medicine at the Johns Hopkins University School of Medicine, Attending on infectious diseases consult service at the main hospital 1 month per year. Responsible for teaching residents and fellows. He was awarded with the following grants: 1. Vanderbilt Infection Pathogenesis and Epidemiology Research Training Program, $233,075, 2011-2012,

2. Vanderbilt International Office Exchange Grant, $15,000, 2008-2009.

3. EGPAF Research Grant (PG-51368), $280,000, 2003-2005.

4. U.S. Department of Defense, $15,000, 2003-2004.

5. National Institutes of Health, Fogarty International Research Collaborative Award (5R03TW005929-02), $100,000, 2002-2004.

He is the Co-Editor for the medical polymers series, beginning with the Handbook of Polymer Applications in Medicine and Medical Devices, first volume published in December 2013 (Williams Andrews).

Affiliations and Expertise

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health

Sina Ebnesajjad

Sina Ebnesajjad
Sina Ebnesajjad is the series editor of Plastics Design Library (PDL) published in the William Andrew imprint of Elsevier. This Series is a unique series, comprising technology and applications handbooks, data books and practical guides tailored to the needs of practitioners. Sina was the editor-in-chief of William Andrew Publishing from 2005 to 2007, which was acquired by Elsevier in 2009.

He retired as a Senior Technology Associate in 2005 from the DuPont fluoropolymers after nearly 24 years of service. Sina founded of FluoroConsultants Group, LLC in 2006 where he continues to work. Sina earned his Bachelor of Science from the School of Engineering of the University of Tehran in 1976, Master of Science and PhD from the University of Michigan, Ann Arbor, all in Chemical Engineering.

He is author, editor and co-author of fifteen technical and data books including five handbooks on fluoropolymers technology and applications. He is author and co-author of three books in surface preparation and adhesion of materials, two of which are in their second editions. Sina has been involved with technical writing and publishing since 1974.

His experiences include fluoropolymer technologies (polytetrafluoroethylene and its copolymers) including polymerization, finishing, fabrication, product development, failure analysis, market development and technical service. Sina holds six patents.

Affiliations and Expertise

Fluoroconsultants Group, Chadds Ford, PA, USA

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