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Handbook of Polymer Applications in Medicine and Medical Devices - 1st Edition - ISBN: 9780323228053, 9780323221696

Handbook of Polymer Applications in Medicine and Medical Devices

1st Edition

Editors: Kayvon Modjarrad Sina Ebnesajjad
eBook ISBN: 9780323221696
Hardcover ISBN: 9780323228053
Imprint: William Andrew
Published Date: 5th December 2013
Page Count: 368
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Table of Contents


Author Biographies

1. Introduction

1.1 History

1.2 A Historical Example

1.3 Anthology Architecture

1.4 Summary


2. Application of Plastics in Medical Devices and Equipment

2.1 Device Industry Overview

2.2 Health-care Trends

2.3 From Legacy Materials to Advanced Specialty Polymers for Devices

2.4 Driving Trends Leading to New Material Requirements

2.5 Market Factors Affecting the Industry

2.6 Conclusion

3. Plastics Used in Medical Devices

3.1 Plastic Compositions

3.2 Medical Devices—Material Selection Process

3.3 Common Medical Device Polymers

3.4 Summary


4. Polymeric Biomaterials

4.1 Introduction

4.2 Polymeric Biomaterials in Ophthalmology

4.3 Polymeric Biomaterials in Orthopedics

4.4 Polymeric Biomaterials in Cardiovascular Diseases

4.5 Polymeric Biomaterials for Wound Closure

4.6 Polymeric Biomaterials in Extracorporeal Artificial Organs

4.7 Polymeric Biomaterials for Nerve Regeneration

4.8 Conclusions and Future Outlook


5. Biofilms, Biomaterials, and Device-Related Infections

5.1 Introduction

5.2 Bacterial Biofilms

5.3 Biofilm Microbiology and Infectious Disease

5.4 Device-Related Infection

5.5 Clinical Examples of Biofilm Infections

5.6 Prevention and Treatment

5.7 Conclusions


6. Adhesives for Medical and Dental Applications

6.1 Introduction

6.2 Natural Adhesives

6.3 Synthetic and Semisynthetic Adhesives

6.4 Cyanoacrylic Adhesives

6.5 Test Methods to Characterize Strength of Tissue Adhesives

6.6 Medical and Dental Applications of Adhesives

6.7 Bone Adhesives

6.8 Dental Applications of Adhesives


7. Silicones

7.1 Chemical Structure and Nomenclature

7.2 Conclusion



8. Review of Research in Cardiovascular Devices

8.1 Introduction

8.2 The Heart Diseases

8.3 The Cardiovascular Devices in Open-Heart Surgery

8.4 The Minimally Invasive Cardiology Tools

8.5 The Technology for Atrial Fibrillation

8.6 Minimally Invasive Surgery

8.7 The Minimally Invasive Valve Implantation

8.8 Support Technology for Surgery Planning

8.9 Conclusions

8.10 Acknowledgments


9. Endotracheal Tube and Respiratory Care

9.1 Introduction

9.2 Properties of the Endotracheal Tube

9.3 Endotracheal Tubes and Other Airway Adjuncts

9.4 Proper Safeguarding of the Airway

9.5 Maintenance of the Endotracheal Tube

9.6 Respiratory Therapies for the Intubated Patient

9.7 Conclusions

9.8 Clinical Pearls


10. Applications of Polyaryletheretherketone in Spinal Implants: Fusion and Motion Preservation

10.1 Introduction

10.2 Origins of Interbody Fusion and the “Cage Rage” of the Late 1990s

10.3 CFR-PEEK Lumbar Cages: The Brantigan Cage

10.4 Threaded PEEK Lumbar Fusion Cages

10.5 Clinical Diagnostic Imaging of PEEK Spinal Cages and Transpedicular Screws

10.6 Subsidence and Wear of PAEK Cages

10.7 Posterior Dynamic Stabilization Devices

10.8 Cervical and Lumbar Artificial Discs

10.9 Summary



11. Microbubble Applications in Biomedicine

11.1 Introduction

11.2 Microbubbles for Ultrasound Imaging

11.3 Targeted Microbubbles

11.4 Microbubbles in Drug and Gene Delivery

11.5 Microbubbles in Gene Delivery

11.6 Other Emerging Applications

11.7 Conclusion


12. Hydrogels in Regenerative Medicine

12.1 Introduction: Relevance of Hydrogels to Regenerative Medicine

12.2 Background and Theory

12.3 Utility in Regenerative Medicine

12.4 Applications of Hydrogels in Regenerative Medicine

12.5 Prospects and Conclusions


13. Biodegradable Polymers

13.1 Introduction

13.2 Biodegradable Polymer Selection Criteria

13.3 Biologically Derived Polymers

13.4 Synthetic Polymers

13.5 Combinations (Hybrids) of Synthetic and Biologically Derived Polymers

13.6 Using Polymers to Create Tissue-Engineered Products

13.7 Conclusion


14. Regulations for Medical Devices and Application to Plastics Suppliers: History and Overview

14.1 History and Introduction

14.2 United States Regulations

14.3 ISO 13485 (European and Global Standard)

14.4 Other Countries

14.5 Global Harmonization Task Force (GHTF)

14.6 Applicability of the Regulations to Material Suppliers

14.7 Conclusion




While the prevalence of plastics and elastomers in medical devices is now quite well known, there is less information available covering the use of medical devices and the applications of polymers beyond medical devices, such as in hydrogels, biopolymers and silicones beyond enhancement applications, and few books in which these are combined into a single reference.

This book is a comprehensive reference source, bringing together a number of key medical polymer topics in one place for a broad audience of engineers and scientists, especially those currently developing new medical devices or seeking more information about current and future applications. In addition to a broad range of applications, the book also covers clinical outcomes and complications arising from the use of the polymers in the body, giving engineers a vital insight into the real world implications of the devices they’re creating. Regulatory issues are also covered in detail. The book also presents the latest developments on the use of polymers in medicine and development of nano-scale devices.

Key Features

  • Gathers discussions of a large number of applications of polymers in medicine in one place
  • Provides an insight into both the legal and clinical implications of device design
  • Relevant to industry, academic and medical professionals
  • Presents the latest developments in the field, including medical devices on a nano-scale


Engineers and Scientists involved in the design, manufacture, development, technical support and marketing of medical devices and materials used in medical device manufacture. Other professionals involved in the medical device industry or the clinical use of medical devices.


No. of pages:
© William Andrew 2013
5th December 2013
William Andrew
eBook ISBN:
Hardcover ISBN:

Ratings and Reviews

About the Editors

Kayvon Modjarrad

Prof. Modjarrad is Adjunct Assistant Professor of Medicine at the Johns Hopkins University School of Medicine, Attending on infectious diseases consult service at the main hospital 1 month per year. Responsible for teaching residents and fellows. He was awarded with the following grants: 1. Vanderbilt Infection Pathogenesis and Epidemiology Research Training Program, $233,075, 2011-2012,

2. Vanderbilt International Office Exchange Grant, $15,000, 2008-2009.

3. EGPAF Research Grant (PG-51368), $280,000, 2003-2005.

4. U.S. Department of Defense, $15,000, 2003-2004.

5. National Institutes of Health, Fogarty International Research Collaborative Award (5R03TW005929-02), $100,000, 2002-2004.

He is the Co-Editor for the medical polymers series, beginning with the Handbook of Polymer Applications in Medicine and Medical Devices, first volume published in December 2013 (Williams Andrews).

Affiliations and Expertise

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health

Sina Ebnesajjad

Sina Ebnesajjad

Sina Ebnesajjad is the series editor of Plastics Design Library (PDL) published in the William Andrew imprint of Elsevier. This Series is a unique series, comprising technology and applications handbooks, data books and practical guides tailored to the needs of practitioners. Sina was the editor-in-chief of William Andrew Publishing from 2005 to 2007, which was acquired by Elsevier in 2009.

He retired as a Senior Technology Associate in 2005 from the DuPont fluoropolymers after nearly 24 years of service. Sina founded of FluoroConsultants Group, LLC in 2006 where he continues to work. Sina earned his Bachelor of Science from the School of Engineering of the University of Tehran in 1976, Master of Science and PhD from the University of Michigan, Ann Arbor, all in Chemical Engineering.

He is author, editor and co-author of fifteen technical and data books including five handbooks on fluoropolymers technology and applications. He is author and co-author of three books in surface preparation and adhesion of materials, two of which are in their second editions. Sina has been involved with technical writing and publishing since 1974.

His experiences include fluoropolymer technologies (polytetrafluoroethylene and its copolymers) including polymerization, finishing, fabrication, product development, failure analysis, market development and technical service. Sina holds six patents.

Affiliations and Expertise

Fluoroconsultants Group, Chadds Ford, PA, USA