Description

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.

Key Features

* covers findings related to cardiovascular, inflammation, and pulmonary diseases * examines issues in oncology, from mTor inhibitors to drug targets * incorporates up-to-date information on drug design and discovery, including delivery to market

Readership

medicinal, pharmaceutical, and organic chemists

Table of Contents

  • Preface
  • Part I: Central Nervous System Diseases
    • Chapter 1: Recent Advances in Corticotropin-Releasing Factor Receptor Antagonists
      • Publisher Summary
      • 1 INTRODUCTION
      • 2 NON-PEPTIDE SMALL MOLECULE CRF-R1 ANTAGONISTS
      • 3 THERAPEUTIC INDICATIONS
      • 4 CLINICAL FINDINGS WITH CRF-R1 ANTAGONISTS
      • 5 SUMMARY
    • Chapter 2: Recent Advances on the 5-HT5A, 5-HT6 and 5-HT7 Receptors
      • Publisher Summary
      • 1 INTRODUCTION
      • 2 THE 5-HT5A RECEPTOR
      • 3 THE 5-HT6 RECEPTOR
      • 4 THE 5-HT7 RECEPTOR
      • 5 CONCLUSIONS
    • Chapter 3: Recent Advances in Voltage-Gated Sodium Channel Blockers: Therapeutic Potential as Drug Targets in the CNS
      • Publisher Summary
      • 1 INTRODUCTION
      • 2 SODIUM CHANNELS AND THERAPEUTIC OPPORTUNITIES
      • 3 ASSAYS
      • 4 CNS AND PNS SODIUM CHANNEL SUBTYPES AND THEIR MODULATORS
      • 5 ADDITIONAL STRUCTURES
      • 6 RECENT CLINICAL DATA
      • 7 CONCLUSION AND FUTURE PERSPECTIVES
    • Chapter 4: Medication Development for the Treatment of Substance Abuse
      • Publisher Summary
      • 1 INTRODUCTION
      • 2 THE ADDICTIVE STATE
      • 3 BEHAVIORAL PHARMACOLOGY MODELS OF ADDICTION
      • 4 PARTIAL AGONIST APPROACH TO MEDICATION DEVELOPMENT
      • 5 OPIOIDS
      • 6 COCAINE
      • 7 STIMULANTS: METHAMPHETAMINE
      • 8 CONCLUSION
  • Part II: Cardiovascular and Metabolic Diseases
    • Chapter 5: GPR40 (FFAR1) Modulators
      • Publisher Summary
      • 1 INTRODUCTION
      • 2 BIOLOGY OF GPR40
      • 3 ARYLPROPIONIC ACIDS
      • 4 LONG CHAIN ALKYL ACID DERIVATIVES
      • 5 ACID ISOSTERES
      • 6 CONCLUSION
    • Chapter 6: Rho-Kinase Inhibitors for Cardiovascular Disease
      • Publis

Details

No. of pages:
584
Language:
English
Copyright:
© 2008
Published:
Imprint:
Academic Press
Electronic ISBN:
9780080921877
Print ISBN:
9780123743442