Microfluidic Cell Culture Systems

About the Authors

Jeffrey Borenstein has a PhD in Physics and more than 20 years of experience in microsystems technology and biomedical devices. His current work is focused on the application of microsystems technologies toward implantable drug delivery systems, artificial organs, and cell-based organ mimetic devices for pharmaceuticals research. He is Director of the Biomedical Engineering Center and a Distinguished Member of the Technical Staff at the Charles Stark Draper Laboratory.

Christopher Bettinger has a PhD in Materials Science and Engineering, and is an Assistant Professor in the Departments of Materials Science and Engineering and Biomedical Engineering at Carnegie Mellon. He has received many honors including the Initiatives in Research Prize from the National Academy of Sciences, the Tissue Engineering and Regenerative Medicine Society Young Investigator Award and the MIT Technology Review TR35.

Sarah Tao has a Ph.D. in Biomedical Engineering with an emphasis on the integration of micro and nanotechnology towards applications in drug delivery and regenerative medicine. Her research has earned numerous accolades including the Society for Biomaterials Award for Outstanding Research, the CRS Eurand Grand Prize for Outstanding Novel Research, and the CRS Capsugel/Pfizer Award for Innovative Research. She previously served as a Senior Member of the Technical Staff at Charles Stark Draper Laboratory and is currently a Manager of New Technologies at the CooperVision Advanced Development Center.

About this Book

An essential professional reference for engineers, biomedical technologists and life scientists, this book provides a practical and scientific guide to applying the techniques of microfluidics and bioMEMS to cell, tissue and organ culture techniques and devices.

The fields of microfluidics and BioMEMS are significantly impacting cell biology research and applications through the application of engineering solutions to human disease and health problems. The dimensions of microfluidic constructs are well suited to the physical scale of the cellular microenvironment, and the many advantages of microfluidics make it an attractive platform for new techniques in bioengineering research.

Internationally recognized experts provide a thoroughly practical guide to the principles of microfluidic device design and operation and their application to cell culture techniques and organ mimetic constructs. The resulting book presents many strategies and techniques that can be readily deployed in the lab. This translational knowledge can be used in many applications, including the acceleration of pharmaceuticals research and validation of new drug models. Equally, the insights into cell culture applications will provide those involved in traditional microfluidics and BioMEMS with an understanding of the specific demands and opportunities presented by a broad range of commercial applications.

• Provides insights into the design and development of microfluidic systems with a specific focus on cell culture applications.

• Focuses on strategies and techniques for the design and fabrication of microfluidic systems and devices for cell culture.

• Provides balanced coverage of microfluidic systems and their application to problems in pharmaceuticals research and development.

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