World Cancer Day, 4 February 2026

Join us in commemorating World Cancer Day on 4th February by exploring our specially curated collection of articles that delve into the multi-faceted aspects of this pervasive disease. This collection will provide you with a comprehensive overview of the latest advancements in cancer research and treatment.

Cancer Epidemiology

• Updated cancer burden in oldest old: A population-based study using 2022 Globocan estimates

• Breast cancer characteristics in low- and middle-income countries: An umbrella review

Cancer Letters

• A novel axis of circKIF4A-miR-637-STAT3 promotes brain metastasis in triple-negative breast cancer

• Autophagy-driven regulation of cisplatin response in human cancers: Exploring molecular and cell death dynamics

• Glutamine transporter SLC38A3 promotes breast cancer metastasis via Gsk3β/β-catenin/EMT pathway

• Colorectal cancer-associated fibroblasts inhibit effector T cells via NECTIN2 signaling

Cancer Pathogenesis and Therapy

• Overview of skin cancer types and prevalence rates across continents

• Advances in nanoparticle-mediated cancer therapeutics: Current research and future perspectives

• Cardiotoxicity in platinum-based chemotherapy: Mechanisms, manifestations, and management

Cancer Treatment and Research Communications

• Programmed death ligand-1 (PD-L1) clone 22C3 expression in resected colorectal cancer as companion diagnostics for immune checkpoint inhibitor therapy: A comparison study and inter-rater agreement evaluation across proposed cut-offs and predictive (TPS, CPS and IC) scores

• ctDNA-based minimal residual disease detection in lung cancer patients treated with curative intended chemoradiotherapy using a clinically transferable approach

• Paclitaxel resistance in breast cancer: Current challenges and recent advanced therapeutic strategies

Chinese Medical Journal Pulmonary and Critical Care Medicine

• Temporal trends in the burden of tracheal, bronchial, and lung cancer in China and globally: A comprehensive analysis from 1990 to 2021

• Mechanisms and current advances in treating KRAS-mutated lung cancer

• Burden of chemotherapy-induced myelosuppression (CIM) in Chinese patients with extensive-stage small cell lung cancer (ES-SCLC): A retrospective real-world study

Clinical and Translational Radiation Oncology

• Clinical evidence and reporting standards in reirradiation: Insights from 28 studies at ESTRO 2025, endorsed by the ESTRO reirradiation focus group

• Pan-Cancer profiling of ferroptosis-related genes reveals prognostic biomarkers and sex-specific associations

Clinical Surgical Oncology

• Clinical application and potential benefits of En-bloc biopsy based on minimally invasive surgery in advanced lung cancer

• Effects of preoperative biliary drainage on the outcomes of surgical treatment in cholangiocarcinoma: A propensity score matching analysis

• Enhancing informed consent in oncological surgery through digital platforms and artificial intelligence

• Individualized surgical approach based on Bismuth-Corlette classification for perihilar cholangiocarcinoma

Current Problems in Cancer

• Current perspectives of KRAS in non-small cell lung cancer

• Blood-based multi-cancer detection: A state-of-the-art update

• Management of metastatic pheochromocytomas and paragangliomas: when and what

Current Problems in Cancer: Case Reports

• ML: Early Breast Cancer Diagnosis

• Severe scalp ulcerations and granulomata during treatment with amivantamab

• Larotrectinib in NTRK3 fusion–positive metastatic secretory carcinoma of the breast: A case study

Cytotherapy

• Comprehensive characterization of cytopenia after chimeric antigen receptor-T cell infusion in patients with relapsed or refractory multiple myeloma

• Efficacy of chimeric antigen receptor engineered natural killer cells in the treatment of hematologic malignancies: a systematic review and meta-analysis of preclinical studies

• Allogeneic hematopoietic stem cell transplantation using reduced intensity conditioning regimen for patients with acute myeloid leukemia not in complete remission

• The next innovations in chimeric antigen receptor T cell immunotherapies for cancer

European Journal of Cancer

• Assessing quality of life in individuals with hereditary cancer risk: Results from phases 1–3a of the EORTC QLQ-HCR30 questionnaire

• Informative censoring in maintenance therapy trials for advanced ovarian cancer: An empirical assessment of its impact on treatment benefit

EJC Paediatric Oncology

• Evaluation of the impact of adherence to infection prevention measures on the quality of life in children with hematologic malignancies

• Pain management during interventions in paediatric oncology in Europe – Results from a pan-European survey

EJC Skin Cancer

• Efficacy of combined BRAF-MEK inhibitor second-line therapy in patients with non-resectable or metastatic BRAFV600-positive melanoma after prior immunotherapy: A retrospective EUMelaReg multicenter study

• Long-term outcomes of cutaneous basal cell and squamous cell carcinomas with < 1 mm close primary surgical excision margins managed in a UK tertiary centre multidisciplinary team

European Journal of Surgical Oncology

• Malnutrition in cancer patients: Causes, consequences and treatment options

• Epidemiology of cholangiocarcinoma

Intelligent Medicine

• The performance of covidence: an artificial intelligence-based tool for title and abstract screening in a breast cancer evidence-based clinical practice guideline

• Targeting lateral pelvic lymph nodes in rectal cancer: response to neoadjuvant therapy and artificial intelligence driven clinical decision support

International Journal of Gynecological Cancer

• Circulating tumor DNA in the diagnosis of ovarian cancer: a systematic review

• European Society of Gynaecological Oncology resource-stratified guidelines for the management of patients with cervical cancer

• Checkpoint inhibitor rechallenge in advanced endometrial cancer: revisiting the immune landscape beyond first-line therapy

International Journal of Particle Therapy

• Relative Biological Effectiveness—Clinical Practice at US Proton Therapy Centers

• Long-Term Outcomes of Consolidative Proton Therapy for Pediatric Classical Hodgkin Lymphoma

• Proton-Based Re-Irradiation of Locally Recurrent Pediatric Brain Tumors in Close Proximity to the Brainstem

• Radioresistant, Rare, Recurrent, and Radioinduced: 4Rs of Hadrontherapy for Patients Selections

Lung Cancer

• Is sublobar resection a valid option for radiologically pure-solid clinical stage IA non-small cell lung cancer?: insights from real-world data and current status

• Survival outcomes of patients with uncommon EGFR mutations in surgically resected lung adenocarcinoma: A multi-institutional real-world database study (CReGYT-01 EGFR study)

Magnetic Resonance Imaging

• Combination of clinicopathological and MRI based radiomics features in predicting homologous recombination repair genes mutations in prostate cancer

• Prediction of pathological risk factors in rectal cancer using combined extracellular volume fraction from T1 mapping and apparent diffusion coefficient

• Development and validation of a prognostic prediction nomogram incorporating MRI and clinicopathological features in breast cancer patients after neoadjuvant chemotherapy

Neoplasia

• Targeting of oncogenic AAA-ATPase TRIP13 reduces progression of pancreatic ductal adenocarcinoma

• The role of glycolysis in tumorigenesis: From biological aspects to therapeutic opportunities

• Genomic profiling in GIST: Implications in clinical outcome and future challenges

Oral Oncology

• Head and neck lymphedema after radiotherapy − Prevalence, changes and associated factors − a prospective observational cohort study

• Evolution of testing for the diagnosis of human papillomavirus (HPV) status in head and neck squamous cell carcinoma: Where from and where to?

• European surgical guidelines: transoral robotic surgery for head and neck cancers

Oral Oncology Reports

• Role of molecular driver mutations in recurrence of early-stage laryngeal cancer following narrow field definitive radiotherapy

• Submental island flap for reconstruction of preauricular defects: A narrative review

• LeChat in oral pathology: Assessment of its immunohistochemical marker selection accuracy in salivary gland tumors

Physics and Imaging in Radiation Oncology

• An ESTRO-EPTN Delphi consensus on robustness evaluation in proton therapy

• Comparative evaluation of static and dynamic 4D dose recalculations in pencil beam scanning proton therapy for oesophageal cancer

Precision Medicine and Engineering

• Intratumor heterogeneity in breast cancer: Tracing its origins and translating findings into clinical practice

• Nanomedicines targeting myeloid cells for breast cancer therapy

• MXene-based functional nanomaterials and their applications in cancer diagnosis and therapy

Radiation Medicine and Protection

• Expert consensus on radiotherapy combined with immunotherapy for esophageal cancer (2024 edition)

• The influence of breast cancer susceptibility genes on radiotherapy efficacy and adverse toxicities

Radiotherapy and Oncology

• ESMO-ESTRO consensus statements on the safety of combining radiotherapy with CDK4/6, HER2, PARP, or mTOR inhibitors

• Low-Dose Radiotherapy for Primary Cutaneous Indolent B-Cell Lymphomas: a Multicenter Retrospective Study

Seminars in Oncology

• Tumor tough, therapy smarter: Rethinking CAR-T for pancreatic cancer

• Chemotherapy plus immunotherapy as first line combination in older patients with extensive stage small cell lung cancer: A systematic review and meta-analysis

• The effects of microbiota-derived short-chain fatty acids on T lymphocytes: From autoimmune diseases to cancer

Surgical Oncology Insight

• The neoadjuvant approach to treatment of breast cancer: Multidisciplinary management to improve outcomes

• Society of surgical oncology medical student & trainee primer for breast surgical oncology

• Malignant bowel obstruction: Historical lessons, current trends, and future directions

Technical Innovations & Patient Support in Radiation Oncology

• Green radiotherapy: AITRO survey on sustainability awareness among Italian radiation therapists

• Comparative dosimetric analysis of deep inspiration breath-hold versus free breathing radiotherapy in lung cancer: special emphasis on cardiac and subcardiac structure protection

Translational Oncology

• Clinical applications of cerebrospinal fluid liquid biopsies in central nervous system tumors

• Extent and clinical significance of the therapy-relevant tight junction protein Claudin 18.2 in pancreatic ductal adenocarcinoma - real-world evidence

• A Novel Epigenetic Strategy to Concurrently Block Immune Checkpoints PD-1/PD-L1 and CD155/TIGIT in Hepatocellular Carcinoma