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PharmaPendium

Optimize drug safety and toxicology for better clinical outcomes

PharmaPendium is a drug safety and toxicology solution that combines trusted pharmacology and toxicology data with innovative tools. Toxicologists and drug safety experts get critical drug safety insights to make informed drug safety decisions faster. The activity dataset delivers curated pharmacology data from FDA and EMA documents, linking drug-target interactions to therapeutic benefits and potential safety risks.

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How to predict off-target adverse drug reactions (ADRs)

Screenshot of Pharmapendium drug safety margin tool

The Safety Margin Tool helps predict and mitigate ADRs by leveraging curated preclinical and clinical data to identify off-target effects early. Developed in partnership with Novartis, the tool:

  • Enables comparative safety profiling across compounds to inform lead selection and optimization

  • Provides mechanistic insight into adverse events, including those related to polypharmacy

  • Supports dosing strategy optimization to improve therapeutic safety and reduce the risk of late-stage failures

How to analyze toxicology data for drug safety decisions

Screenshot of Pharmapendium Tox Navigator to analyze toxicology data

Tox Navigator, developed in partnership with Pfizer, helps you easily analyze toxicology data, supporting cross-species comparisons to assess translational doses. Use Tox Navigator to:

  • Refine your search with specific criteria related to drugs, targets, mechanism of action, primary/secondary targets, indications and species

  • Specify dosage criteria using various units, including Human Equivalent Dose (HED), Total Daily Dose (TDD) and Dose in source units

  • Select drugs by translational score or alphabetically by drug name