Trophic Regulation of the Basal Ganglia: Focus on Dopamine Neurons examines neurotransmitters. The book first discusses the role of fibroblast growth factor-2 (FGF-2) and ganglioside GM1 and the trophic regulation of the basal ganglia. Biochemical and histochemical studies on the cellular localization of FGF-2; mapping of FGF-2 and its receptors in the basal ganglia postnatally and adulthood; and mapping of the ganglioside GM1 distribution in the basal ganglia are presented. The text also explains glucocorticoid and estrogen effects on the nigrostriatal and mesolimbic dopaminergic systems; factors associated to dopaminergic cell death in Parkinson's disease; and compensatory mechanisms at dopamine D-2 receptors. The book also describes the effects of brain-derived neurotrophic factor on injured dopaminergic neurons; role of gangliosides and trophic factors in brain repair; and features of the trophic action of polyamines. The text also underscores the presence of interleukin-1 in the central nervous system; neuropeptides synthesis in astrocytes; and astrocytic kynurenines as modulators of dopaminergic function in the rat basal ganglia. The selection is a good source of information for readers wanting to study neurotransmitters.

Table of Contents

1. Fibroblast Growth Factor-2, Ganglioside GM1 and the Trophic Regulation of the Basal Ganglia. Focus on the Nigrostriatal Dopamine Neurons 2. DARPP-32/Protein Phosphatase-1/Na+/K+ATPase System: A Mechanism for Bidirectional Control of Cell Function 3. Muscle-Derived Differentiation Factor and its Regulation of the Tyrosine Hydroxylase Gene in the Developing, Adult and Lesioned Rat Brain 4. Glucocorticoid and Estrogen Effects on the Nigrostriatal and Mesolimbic Dopaminergic Systems 5. Factors Associated to Dopaminergic Cell Death in Parkinson's Disease 6. Compensatory Mechanisms at Dopamine D-2 Receptors 7. Oxidative Stress and Reduced Receptor Responsiveness in Senescence 8. Expression, Regulation and Receptor Distribution of Neurotrophins in the Mammalian Central Nervous System 9. Localization of Neurotrophins and Their Receptors at the mRNA and Protein Level 10. Effects of Brain-Derived Neurotrophic Factor on Injured Dopaminergic Neurons 11. Fibroblast Growth Factors and Parkinson's Disease 12. Homeobox Peptides as a Novel Class of Neurotrophic Molecules 13. Growth Factors Involved in the Development, Maturation and Neuroplasticity of Midbrain Dopamine Neurons 14. Ganglioside and Growth Factor Interactions Promote Mesencephalic Cell Survival from the Excitotoxic Actions of 2,4,5-Trihydroxyphenylalanine 15. Trophic Factors and GM1 Ganglioside in the Basal Ganglia 16. The Role of Gangliosides and Trophic Factors in Brain Repair 17. Features of the Trophic Action of Polyamines 18. Acidic and Basic Fibroblast Growth Factors are Present in, and Produce Effects upon, Mesencephalic Dopamine Neurons 19. Presence of Interleukin-1 in the Central Nervous System 20. Cellular Immediate-Early Genes in the Nervous System: Genes for All Reasons? 21. Neuropeptide Synthesis in Astrocytes: Possible Trophic Roles 22. Beta-Amyloid Precursor: A Neuronal and Glial-Derived Protein with Trophic-like Activities 23. Neuron-Glia Interactions: Receptor Induced Events in


No. of pages:
© 1994
Electronic ISBN:
Print ISBN:

About the editors