Trends in High Pressure Bioscience and Biotechnology, Volume 19

1st Edition

Editors: R. Hayashi
Hardcover ISBN: 9780444509963
eBook ISBN: 9780080543222
Imprint: Elsevier Science
Published Date: 21st January 2002
Page Count: 668
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Table of Contents

Introduction. High pressure bioscience and biotechnology: a century and a decade perspective (K. Heremans).

Protein and macromolecules. Structural features and dynamics of protein unfolding (R. Lange, et al.).

A discussion of the physical basis for the pressure unfolding of proteins (C.A. Royer).

Thermal and pressure stability of Phe46 mutants of ribonuclease A (E. Chatani, R. Hayashi, R. Lange, C. Balny).

Pressure and temperature-induced denaturation of carboxypeptidase Y and procarboxypeptidase Y (M. Kato, R. Hayashi, R. Lange, C. Balny).

Compression and expansion of biomatter: predicting the unpredictable? (K. Heremans, et al.).

Fluctuation of apomyoglobin monitored from H/D exchange and proteolysis under high pressure (N. Tanaka, et al.).

Effect of pressure treatment on hydrophobicity and SH groups interactions of myofibrillar proteins (N. Chapleau, S. Delépine, M. de Lamballerie-Anton).

Effects of mutation and ligand binding on the compressibility of a protein (K. Gekko, T. Kamiyama, E. Ohmae, K. Katayanagi).

Effect of glycosylation on the mechanism of renaturation of carboxypeptidase Y (M. Dumoulin, et al.).

Pressure studies on protein folding, misfolding, protein-DNA interactions and amyloidogenesis (D. Ishimaru, et al.).

High pressure gel mobility shift analysis and molecular dynamics: investigating specific protein-nucleic acid recognition (T.W. Lynch, et al.).

Aggregation and gel formation of proteins after combined pressure-temperature treatment (L. Smeller, F. Meersman, J. Fidy, K. Heremans).

Behavior of actin under high


A world wide interest in the various aspects of high pressure in the field of biological science led to the First International Conference on High Pressure Bioscience and Biotechnology in Kyoto, Japan. High pressure bioscience encompasses the fields of food sciences, pharmacy and medical fields and some high pressure techniques are used in the production of industrial products. Moreover, high pressure is a valuable tool for the study of natural macromolecules including biomembranes which are composed, primarily, of lipid and protein. Many intermediate processes in the pressure-induced protein unfolding have been discovered, as a result. This book covers the entire range of current high pressure bioscience and its possible applications.


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About the Editors

R. Hayashi Editor

Affiliations and Expertise

Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa, Sakyo-ku, Kyoto 606-8502, Japan