Theranostic Approach for Pancreatic Cancer - 1st Edition - ISBN: 9780128194577

Theranostic Approach for Pancreatic Cancer

1st Edition

Editors: Ganji Purnachandra Nagaraju Sarfraz Ahmad
Paperback ISBN: 9780128194577
Imprint: Academic Press
Published Date: 7th August 2019
Page Count: 410
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Theranostic Approach for Pancreatic Cancer modulates the biologic properties of stroma in pancreatic cancer by targeting the several chemotherapy resistance mechanisms to impede their malignant property through introducing new strategies and drugs for tackling the disease. It brings information about ongoing research as well as clinical data about pancreatic cancer and provides detailed descriptions about diagnostic and therapeutic options for easy understanding. The book discusses several topics related to pancreatic cancer, such as stem cells, drug resistance and pancreatic tumor microenvironment, the latest developments in chemotherapy for metastatic cancer and chemoprevention, and epigenome as a therapeutic strategy.

Additionally, it encompasses a discussion on theranostic clinical applications for personalized treatment and management of pancreatic cancer. The book is a valuable resource for cancer researchers, oncologists, and several members of the biomedical field who need to understand more about the diagnosis and treatment of pancreatic cancer.

Key Features

  • Provides information on the roadblocks of chemotherapy in patients with newly diagnosed and metastatic pancreatic cancer<
  • Discusses treatment options available currently and prospective options for the future
  • Focuses especially on stroma, tumor microenvironment, stem cells, stellate cells, transcription factors, growth factors, and important signaling pathways as already tested types of treatment


Cancer researchers, medical scientists, clinicians, graduate students

Table of Contents

  1. Biology, pathophysiology and epidemiology of pancreatic cancer
    2. Diagnosis of pancreatic cancer
    3. Current knowledge on drug resistance and therapeutic approaches to eliminate pancreatic cancer stem cells
    4. Drug resistance and microenvironment in pancreatic cancer
    5. The role of tumor microenvironment in the metastasis of pancreatic cancer and immunotherapy
    6. Latest developments in chemotherapy for metastatic pancreatic cancer
    7. Genetic manipulations with chemotherapy in pancreatic cancer
    8. Genetic predisposition for pancreatic cancer
    9. Pancreatic cancer resistance to chemotherapy: Resensitization strategies using resveratrol
    10. Anti-cancer activity of a small molecule, tolfenamic acid: An emphasis on pancreatic cancer
    11. Targeting the epigenome as a therapeutic strategy for pancreatic tumors - Non-coding RNAs and chromatin remodelers
    12. Pancreatic cancer chemoprevention: A review on molecular pathways involved in carcinogenesis and targeting with terpenoids, a new potential anti-tumor drugs
    13. Meta-analysis on MTHFR polymorphisms and pancreatic cancer susceptibility
    14. Therapeutic vaccines for pancreatic cancer
    15. Epidermal growth factor receptor role in pancreatic cancer
    16. Recent advances in molecular diagnostics and therapeutic targets for pancreatic cancer


No. of pages:
© Academic Press 2019
7th August 2019
Academic Press
Paperback ISBN:

About the Editor

Ganji Purnachandra Nagaraju

Dr. Nagaraju GP is a faculty member in the Department of Hematology and Medical Oncology at Emory University School of Medicine. Dr. Nagaraju obtained his MSc and his PhD, both in Biotechnology, from Sri Venkateswara University in Tirupati, Andhra Pradesh, India. Dr. Nagaraju received his DSc from Berhampur University in Berhampur, Odisha, India. Dr. Nagaraju’s research focuses on translational projects related to gastrointestinal malignancies. He has published over 70 research papers in highly reputed International journals and has presented more than 50 abstracts at various national and international conferences. Dr, Nagaraju is author and editor of several published books including 1. Role of Tyrosine Kinases in Gastrointestinal Malignancies, 2. Role of Transcription Factors in Gastrointestinal Malignancies and 3. Breaking Tolerance to Pancreatic Cancer Unresponsiveness to Chemotherapy. He serves as editorial board member of several internationally recognized academic journals. Dr. Nagaraju is an associate member of the Discovery and Developmental Therapeutics research program at Winship Cancer Institute. Dr. Nagaraju has received several international awards including FAACC. He also holds memberships with the Association of Scientists of Indian Origin in America (ASIOA), the Society for Integrative and Comparative Biology (SICB), The Science Advisory Board, The RNA Society, The American Association for Clinical Chemistry (AACC) and the American Association of Cancer Research (AACR).

Affiliations and Expertise

Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA

Sarfraz Ahmad

Dr. Ahmad is Director of Clinical Research at Gynecologic Oncology Department of AdventHealth (formerly Florida Hospital) Cancer Institute (FHCI), Orlando, FL, USA. He earned his Ph.D. degree in Biochemistry from North-Eastern Hill University, Shillong. Before joining FHCI in 2002, he spent 10-years in research and teaching at Loyola University of Chicago and University of Illinois at Chicago’s Division of Hematology/Oncology, College of Medicine. He has trained several fellows, residents, medical students, and graduate/undergraduate students during their scholarly research projects. He is also Professor of Medical Education at University of Central Florida College of Medicine and Professor of Clinical Sciences at Florida State University College of Medicine, Orlando, USA. Dr. Ahmad’s current research focus is on the analysis of clinico-pathologic and surgical outcomes of oncology patients and to better understand the cellular/molecular mechanisms of cancer and related thromboembolic / hematologic disorders. His investigations are also aimed towards the evaluation of novel treatment options (chemo/cellular/immuno-therapies) for better management of hemato-oncologic patients. His past research interests focused on the anticoagulant, antithrombin, antiplatelet, and thrombolytic drug development for the management of hematologic and cardiovascular patients. In these various areas of biomedical research, Dr. Ahmad has published nearly 200 peer-reviewed scholarly research articles and book chapters, and nearly 400 scientific abstracts, which are extensively cited globally. He is a reviewer and has editorial responsibilities for several biomedical journals/books; and has received several competitive research grants and national/international awards for his research accomplishments/contributions.

Affiliations and Expertise

AdventHealth Cancer Institute, Orlando, FL, USA

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