The Proteasomal System in Aging and Disease

The Proteasomal System in Aging and Disease

1st Edition - July 5, 2012

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  • Editor: Tilman Grune
  • eBook ISBN: 9780123978653
  • Hardcover ISBN: 9780123978639

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This volume of Progress in Molecular Biology and Translational Science discusses cutting-edge research of proteasomes and proteasome-associated proteins and cellular systems. The volume is split into two sections. The first part discusses the current knowledge of the structure, function, and regulation of the proteasomal system. The second part describes the role of the proteasome in aging and disease.

Key Features

  • Contributions from leading authorities
  • Informs and updates on all the latest developments in the field


Molecular biologists and researchers of proteasomes

Table of Contents

    1. Structure of the Proteasome
    2. Tobias Jung and Tilman Grune

    3. Structure and Function of the Ubiquitin-Proteasome System: Modulation of Components
    4. Niki Chondrogianni and Efstathios S. Gonos

    5. Immunoproteasomes: Structure, Function, and Antigen Presentation
    6. Deborah A. Ferrington and Dale S. Gregerson

    7. Interactions of the Proteasomal System with Chaperones – Protein Triage and Protein Quality Control
    8. Marc Kästle and Tilman Grune

    9. Proteasome Inhibitors
    10. Boris Cvek

    11. Degradation of Damaged Proteins - The Main Function of the 20S Proteasome
    12. Andrew. M. Pickering and Kelvin. J. A. Davies

    13. Changes of the Proteasomal System During the Aging Process
    14. Martin A. Baraibar and Bertrand Friguet

    15. Proteasome and Cancer
    16. Betul Catalgol

    17. The Ubiquitin Proteasome System and Cardiovascular Disease.
    18. Saul R. Powell, Joerg Herrmann, Amir Lerman, Cam Patterson, Xuejun Wang

    19. Role of the Ubiquitin-Proteasome in Protein Quality Control and Signaling: Implication in the Pathogenesis of Eye Diseases
    20. Fu Shang and Allen Taylor

    21. Proteasome and Neurodegeneratıve Dıseases

    Betul Catalgol and Tilman Grune

Product details

  • No. of pages: 436
  • Language: English
  • Copyright: © Academic Press 2012
  • Published: July 5, 2012
  • Imprint: Academic Press
  • eBook ISBN: 9780123978653
  • Hardcover ISBN: 9780123978639

About the Serial Volume Editor

Tilman Grune

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