The Laboratory Rat

The Laboratory Rat

3rd Edition - November 10, 2019

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  • Editors: Mark Suckow, F.Claire Hankenson, Ronald Wilson, Patricia Foley
  • Hardcover ISBN: 9780128143384
  • eBook ISBN: 9780128143391

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The third edition of The Laboratory Rat features updated information on a variety of topics, including rats as research models for basic and translational research in areas such as genomics, alcoholism, diabetes, metabolic syndrome, obesity, neuroscience, spinal cord injury, traumatic brain injury, regenerative medicine, and infectious disease. New information related to the husbandry and veterinary care of rats is provided including topics related to nutrition, reproduction, anesthesia and surgery, infectious and noninfectious disease, and the care of surgical and other fragile models.  It is a premier source of information on the laboratory rat, this book will be of interest to veterinary and medical students, senior graduate students, postdocs and researchers who utilize animals in biomedical research.

Key Features

  • New chapters on the care of surgical and fragile models and on the use of rats in research areas such as alcoholism, regenerative medicine, spinal cord injury, traumatic brain injury, and others are included.
  • All chapters were written by scientific and veterinary experts.
  • This book condenses information from many sources on topics related to the care and use of rats in research.
  • It is the premier source of information on the laboratory rat.


Veterinarians; researchers who use rats in their experiments on aging, drug addiction, cancer, spinal cord injury, cardiovascular disease, Alzheimer’s disease, spontaneous diabetes, arthritis, and so on

Table of Contents

  • Background of the laboratory rat
    1. Historical Foundations
    2. Taxonomy and Stocks and Strains
    3. Translational Potential of Rats in Research

    Biology and care
    4. Functional Anatomy and Physiology
    5. Clinical Pathology of the Rat
    6. Reproduction and Breeding
    7. Assisted Reproductive Technologies and Genetic Modification in Rats
    8. Analysis of Behavior in Laboratory Rats
    9. Nutrition
    10. Housing and Environment

    Clinical care and disease
    11. Medical Management and Diagnostic Approaches
    12. Bacterial, Mycoplasmal, and Mycotic Infections
    13. Viral Disease
    14. Parasitic Diseases
    15. Neoplastic Disease
    16. Metabolic, Traumatic, and Miscellaneous Diseases
    17. Anesthesia, Analgesia, and Euthanasia
    18. Care of Surgical and Other Fragile Models

    Rats as research models
    19. General Experimental Techniques
    20. Integrating Biology with Rat Genomic Tools
    21. Gnotobiotics and the Microbiome
    22. Toxicology
    23. Embryology and Teratology
    24. Rat Immunology
    25. Cardiovascular Research
    26. Rat Models of Alcohol Use Disorder
    27. Rat Models of Obesity, Metabolic Syndrome, and Diabetes
    28. The Rate in Neuroscience Research
    29. Rat Models of Central Nervous System Injury
    30. Use of the Rat as a Model in Regenerative Medicine
    31. Rat Models of Infectious Disease

Product details

  • No. of pages: 1180
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: November 10, 2019
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128143384
  • eBook ISBN: 9780128143391

About the Editors

Mark Suckow

Mark Suckow received his DVM from the University of Wisconsin in 1987 and subsequently completed a post-doctoral residency in laboratory animal medicine at the University of Michigan in 1990. He spent 8 years as a clinical laboratory animal veterinarian at Purdue University and then 17 years at the University of Notre Dame where he served as Director of the Freimann Life Science Center and later as Associate Vice President for Research Compliance. Prior to coming to the University of Kentucky, he was Professor of Veterinary Population Medicine and Director, Research Animal Resources at the University of Minnesota. With an interest in cancer models, biomaterials models, and vaccines, Dr. Suckow has functioned as an independent and collaborative investigator and has published in refereed journals and has seven issued patents related to vaccine adjuvants and cancer vaccines. He has written or edited over 20 books on topics related to research and laboratory animal medicine. Further, he served as the 2006 President of the American Association for Laboratory Animal Science and the 2011 President of the American Society of Laboratory Animal Practitioners; and currently he serves on the AVMA Council on Research and is a member of the Council on Accreditation of AAALAC, International.

Affiliations and Expertise

Associate Vice President for Research, Attending Veterinarian, University of Kentucky, USA.

F.Claire Hankenson

F. Claire Hankenson, DVM, MS, is the Director of MSU Campus Animal Resources and Attending Veterinarian at the Michigan State University. Research interests are refinements in the case and use of animals involved in research studies, particularly rodent clinical medicine, tail biopsy evaluations and humane endpoints.

Affiliations and Expertise

Director, MSU Campus Animal Resources, Michigan State University, East Lansing, MI, USA

Ronald Wilson

Ronald P. Wilson, VMA, MS, DACLAM, is the Professor and Chair of Comparative Medicine at Pennsylvania State University. Research interests are related to experimental surgery, pain, analgesia and anesthesia of laboratory animals.

Affiliations and Expertise

Professor and Chair, Department of Comparative Medicine, Penn State University College of Medicine, Hershey, PA, USA

Patricia Foley

Patricia L. Foley, DVM, DCLAM, is the Director, Division of Comparative Medicine at Georgetown University.

Affiliations and Expertise

Director, Division of Comparative Medicine, Georgetown University, Washington, DC, USA

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