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The Laboratory Rat - 3rd Edition - ISBN: 9780128143384, 9780128143391

The Laboratory Rat

3rd Edition

Editors: Mark Suckow F.Claire Hankenson Ronald Wilson Patricia Foley
Hardcover ISBN: 9780128143384
eBook ISBN: 9780128143391
Imprint: Academic Press
Published Date: 10th November 2019
Page Count: 1180
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Table of Contents

Background of the laboratory rat
1. Historical Foundations
2. Taxonomy and Stocks and Strains
3. Translational Potential of Rats in Research

Biology and care
4. Functional Anatomy and Physiology
5. Clinical Pathology of the Rat
6. Reproduction and Breeding
7. Assisted Reproductive Technologies and Genetic Modification in Rats
8. Analysis of Behavior in Laboratory Rats
9. Nutrition
10. Housing and Environment

Clinical care and disease
11. Medical Management and Diagnostic Approaches
12. Bacterial, Mycoplasmal, and Mycotic Infections
13. Viral Disease
14. Parasitic Diseases
15. Neoplastic Disease
16. Metabolic, Traumatic, and Miscellaneous Diseases
17. Anesthesia, Analgesia, and Euthanasia
18. Care of Surgical and Other Fragile Models

Rats as research models
19. General Experimental Techniques
20. Integrating Biology with Rat Genomic Tools
21. Gnotobiotics and the Microbiome
22. Toxicology
23. Embryology and Teratology
24. Rat Immunology
25. Cardiovascular Research
26. Rat Models of Alcohol Use Disorder
27. Rat Models of Obesity, Metabolic Syndrome, and Diabetes
28. The Rate in Neuroscience Research
29. Rat Models of Central Nervous System Injury
30. Use of the Rat as a Model in Regenerative Medicine
31. Rat Models of Infectious Disease


The third edition of The Laboratory Rat features updated information on a variety of topics, including rats as research models for basic and translational research in areas such as genomics, alcoholism, diabetes, metabolic syndrome, obesity, neuroscience, spinal cord injury, traumatic brain injury, regenerative medicine, and infectious disease. New information related to the husbandry and veterinary care of rats is provided including topics related to nutrition, reproduction, anesthesia and surgery, infectious and noninfectious disease, and the care of surgical and other fragile models. It is a premier source of information on the laboratory rat, this book will be of interest to veterinary and medical students, senior graduate students, postdocs and researchers who utilize animals in biomedical research.

Key Features

  • New chapters on the care of surgical and fragile models and on the use of rats in research areas such as alcoholism, regenerative medicine, spinal cord injury, traumatic brain injury, and others are included.
  • All chapters were written by scientific and veterinary experts.
  • This book condenses information from many sources on topics related to the care and use of rats in research.
  • It is the premier source of information on the laboratory rat.


Veterinarians; researchers who use rats in their experiments on aging, drug addiction, cancer, spinal cord injury, cardiovascular disease, Alzheimer’s disease, spontaneous diabetes, arthritis, and so on


No. of pages:
© Academic Press 2019
10th November 2019
Academic Press
Hardcover ISBN:
eBook ISBN:

Ratings and Reviews

About the Editors

Mark Suckow

Mark A. Suckow, DVM, DACLAM, is the Associate Vice President for Research, Attending Veterinarian, and Professor of Biomedical Engineering at the University of Kentucky. He is on the council on Accreditation at the Association for Assessment and Accreditation of Laboratory Animal Care International. Dr. Suckow has 25 years of experience with IACUC organization and regulatory compliance, laboratory animal medicine, research with a variety of animal models, and animal facility design and management. He is the previous editor of laboratory animal publications with CRC Press and AP/Elsevier, including Principles of Animal Research, Research Regulatory Compliance and The Laboratory Rabbit, Guinea Pig, Hamster and Other Rodents

Affiliations and Expertise

Associate Vice President for Research, Attending Veterinarian, Professor, Biomedical Engineering, University of Kentucky, Lexington, KY.

F.Claire Hankenson

F. Claire Hankenson, DVM, MS, is the Director of MSU Campus Animal Resources and Attending Veterinarian at the Michigan State University. Research interests are refinements in the case and use of animals involved in research studies, particularly rodent clinical medicine, tail biopsy evaluations and humane endpoints.

Affiliations and Expertise

Director, MSU Campus Animal Resources, Michigan State University, East Lansing, MI, USA

Ronald Wilson

Ronald P. Wilson, VMA, MS, DACLAM, is the Professor and Chair of Comparative Medicine at Pennsylvania State University. Research interests are related to experimental surgery, pain, analgesia and anesthesia of laboratory animals.

Affiliations and Expertise

Professor and Chair, Department of Comparative Medicine, Penn State University College of Medicine, Hershey, PA, USA

Patricia Foley

Patricia L. Foley, DVM, DCLAM, is the Director, Division of Comparative Medicine at Georgetown University.

Affiliations and Expertise

Director, Division of Comparative Medicine, Georgetown University, Washington, DC, USA