The Enzymes

The Enzymes

Molecular Machines Involved in Protein Transport across Cellular Membranes

1st Edition - August 28, 2007

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  • Editors: Ross Dalbey, Carla Koehler, Fuyuhiko Tamanoi
  • eBook ISBN: 9780080552163
  • Hardcover ISBN: 9780123739162

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This volume of The Enzymes features high-caliber thematic articles on the topic of molecular machines involved in protein transport across cellular membranes. The book consists of five parts which span the range of membranes including bacterial, endoplasmic reticulum, mitochondrial, chloroplast, and peroxismal.


Biochemists, cell biologists, molecular biologists, biophysicists.

Table of Contents

  • Part I: Crossing bacterial membranes.
    Chapter 1: Cotranslational Protein Targeting in Escherichia Coli.
    Chapter 2: Sec Protein Conducting Channel and SecA.
    Chapter 3: Targeting of Proteins by the Twin-arginine Translocation (Tat) System in Bacteria and Chloroplasts.
    Chapter 4: YidC- A Protein with Multiple Functions in Bacterial Membrane Biogenesis.
    Chapter 5: Disulfide Bond Formation Enzymes.
    Chapter 6: The Identification of the YaeT Complex and its Role in the Assembly of Bacterial Outer Membrane â-barrel Proteins.
    Chapter 7: The Function of the ABC transporter LolCDE in Protein Transport to the Outer Membrane of E. coli.

    Part II: Crossing endoplasmic reticulum membranes.
    Chapter 8: The Signal Recognition Particle and Its Receptor in ER Protein Targeting.
    Chapter 9: The Translocation Apparatus of The Endoplasmic Reticulum.
    Chapter 10: The Role of Bip/Kar2p in the Translocation of Proteins Across the ER Membrane.
    Chapter 11: Calnexin, Calreticulin and their Associated Oxidoreductase ERp57.

    Part III: Crossing mitochondrial membranes.
    Chapter 12: TOM and SAM Machineries in Mitochondrial Protein Import and Outer Membrane Biogenesis.
    Chapter 13: The Role of the Mia40-Erv1 Disulfide Relay System in Import and Folding of Proteins of the Intermembrane Space of Mitochondria.
    Chapter 14: The Function of TIM22 in the Insertion of Inner Membrane Proteins in Mitochondria.
    Chapter 15: The Role of the TIM23 Complex and its Associated Motor Complex (PAM) in Mitochondrial Protein Import.

    Part IV: Crossing chloroplast membranes.
    Chapter 16: The Toc Machinery of the Protein Import Apparatus of Chloroplasts.
    Chapter 17: The Role of the TIC Machinery in Chloroplast Protein Import.
    Chapter 18: The Sec and Tat Protein Translocation Pathways in Chloroplasts.
    Chapter 19: Chloroplast SRP/FtsY and Alb3 in Protein Integration into the Thylakoid Membrane.

    Part V: Crossing peroxisomal membranes.
    Chapter 20: The Role of Shuttling Targeting Signal Receptors and Heat-shock Proteins in Peroxisomal Matrix Protein Import.
    Chapter 21: Function of the Ubiquitin-conjugating Enzyme Pex4p and the AAA Peroxin Complex Pex1p/Pex6p in Peroxisomal Matrix Protein Transport.

Product details

  • No. of pages: 666
  • Language: English
  • Copyright: © Academic Press 2007
  • Published: August 28, 2007
  • Imprint: Academic Press
  • eBook ISBN: 9780080552163
  • Hardcover ISBN: 9780123739162

About the Editors

Ross Dalbey

Affiliations and Expertise

Ohio State University, Columbus, U.S.A.

Carla Koehler

Fuyuhiko Tamanoi

Fuyu Tamanoi is a biochemist who has served on the UCLA School of Medicine and UCLA College faculty since he joined the Department of Microbiology, Immunology & Molecular Genetics in 1993. He became a full professor in 1997.

Affiliations and Expertise

Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles, USA

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