The fourth edition of The Cytokine Handbook provides an encyclopedic coverage of the molecules that induce and regulate immune responses. Now expanded to two volumes, co-edited by Michael T Lotze, and written by over 120 international experts, the scope of the book has been broadened to include a major emphasis on the clinical applications of cytokines. The early chapters discuss individual cytokines, chemokines and receptors. Additional chapters discuss the clinical implications and applications of cytokines, including cytokine gene transfer, antisense therapy and assay systems. This book is essential for researchers and clinicians interested in cytokines, including anyone working in cancer biology, transplantation, infectious diseases, autoimmunity or bioinformatics.

Key Features

Key Features * Covers all main cytokines and chemokines * Written by experts * Up-to-date- includes detailed referencing accessing current, modern literature and reflects the newest findings from the human genome * The new edition has been thoroughly revised and extended (now 2 volumes) as compared to the last edition, including new co-editor (MTL), new authors, new hot topics and new chapters * Includes major emphasis on clinical applications * Extensively illustrated with tables and figures


Research level Immunologists, Pathologists, Cell and Cancer Biologists, Biochemists and Molecular Biologists. Clinicians and Clinical Researchers. Also major market in Pharmaceutical and Biotech Industry. Very significant bulk sales potential. (NB Reachable with use of BiomedSource)

Table of Contents

Volume 1 Preface Foreward Section I Basic Cytokine Biology 1 Cytokines Overview 2 Cytokine Genetics 3 The Phylogeny of Cytokines 4 Cytokine Signalling Section II The Cytokines and Chemokines Subsection A. The Hematopoietin Family Members 5 Growth Hormone and its Receptors 6 Prolactin 7 Erythropoietin 8 Interleukin 2 9 Interleukin 3 10 Interleukin 4 11 Interleukin 5 12 Interleukin 6 13 Interleukin 7 14 Interleukin 9 15 Interleukin 11 16 Interleukin 12 Family: IL-12 17 Interleukin 13 18 Interleukin 15 and Interleukin 21 19 Interleukin 16 20 Interleukin 17 21 Granulocyte-Macrophage 22 Granulocyte Colony-Stimulating Factor and its Receptor 23 M-CSF Subsection B. The Interferon Family Members 24 Type I Interferons 25 Interferon-g 26 Interleukin 10 27 Interleukins 19, 20, 22, 24 and 26 Volume II. Subsection C. The beta trefoil cytokines 28 Interleukin 1 a and b 29 Interleukin 1 Receptor Antagonist 30 Novel Interleukin-1 Homologues 31 Interleukin 18 32 The Fibroblast Growth Factors 33 The Hepatocyte Growth Factor The HGF Receptor, MET 34 Toll-like Receptors: The Origins of Inflammation 35 Lymphotoxins 36 Tumor Necrosis Factor 37 TRAIL/apo2L 38 RANK-L : Receptor Activator of NF-kB Ligan 39 CD95L/FasL its receptor CD95 (APO-1/Fas) 40 HMGB-1/Amphoterin 41 EGF Family Ligand 42 FLT3 Ligand


No. of pages:
© 2003
Academic Press
Print ISBN:
eBook ISBN:

About the editors

Angus Thomson

Affiliations and Expertise

Departments of Surgery and Immunology, Thomas E. Starzl Transplantation Institute, University of Pittsburgh Schools of the Health Sciences, Pittsburgh, Pennsylvania, USA

Michael Lotze

Affiliations and Expertise

Departments of Surgery and Bioengineering, University of Pittsburgh Cancer Institute, University of Pittsburgh Schools of the Health Sciences, Pittsburgh, Pennsylvania, USA


"Thompson and Lotze are to be commended for compiling this comprehensive work...The editors and authors should be commended for this very difficult task in this rapidly advancing field. There are excellent chapters on cytokine genetics, chemokine nomenclature, and the basic biology of each of the cytokines." -ASM NEWS (April 2004)