Protein Homeostasis Diseases

I. Introduction of protein folding and homeostasis
1. Protein folding: how, why, and beyond
2. Protein homeostasis and disease

II. Protein folding and homeostasis at the organismal and proteomic scales
3. Caenorhabditis elegans as a model organism for protein homeostasis diseases
4. Proteome-scale studies of protein stability
5. Classifying disease-associated variants using measures of protein activity and stability

III. Protein homeostasis disturbance in disease: Genetics, mechanisms, and modulation by natural ligands
6. Protein destabilization and degradation as a mechanism for hereditary disease
7. Detection of amyloid aggregation in living systems
8. Molecular mechanisms of amyloid aggregation in human proteinopathies
9. Metals and amyloid gain-of-toxic mechanisms in neurodegenerative diseases
10. Vitamin B6-dependent enzymes and disease
11. Galactosemia: opportunities for novel therapies
12. Protein homeostasis and regulation of intracellular trafficking of G protein-coupled receptors
13. Structure-guided discovery of pharmacological chaperones targeting protein conformational and misfolding diseases
14. Virtual screening in drug discovery: a precious tool for a still-demanding
challenge
15. Differential scanning fluorimetry in the screening and validation of pharmacological chaperones for soluble and membrane proteins
16. Cellular high-throughput screening
17. High-throughput screening for intrinsically disordered proteins by using biophysical methods
18. Natural and pharmacological chaperones against accelerated protein degradation: uroporphyrinogen III synthase and congenital erythropoietic porphyria