Description

Now in its fourth edition, Principles of Tissue Engineering has been the definite resource in the field of tissue engineering for more than a decade. The fourth edition provides an update on this rapidly progressing field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation by the world’s experts of what is currently known about each specific organ system. As in previous editions, this book creates a comprehensive work that strikes a balance among the diversity of subjects that are related to tissue engineering, including biology, chemistry, material science, and engineering, among others, while also emphasizing those research areas that are likely to be of clinical value in the future.

This edition includes greatly expanded focus on stem cells, including induced pluripotent stem (iPS) cells, stem cell niches, and blood components from stem cells. This research has already produced applications in disease modeling, toxicity testing, drug development, and clinical therapies.  This up-to-date coverage of stem cell biology and other emerging technologies –such as brain-machine interfaces for controlling bionics and neuroprostheses– is complemented by a series of new and updated chapters on recent clinical experience in applying tissue engineering, as well as a new section on the application of tissue-engineering techniques for food production. The result is a comprehensive textbook that will be useful to students and experts alike.

Table of Contents

Foreword

Preface

Preface to the Third Edition

Preface to the Second Edition

Preface to the First Edition

List of Contributors

Abstract

Introduction to Tissue Engineering

Chapter 1. The History and Scope of Tissue Engineering

Abstract

Introduction

Scientific Challenges

Cells

Materials

General Scientific Issues

Social Challenges

Further Reading

Chapter 2. The Challenge of Imitating Nature

Abstract

Acknowledgment

Introduction

The Basic Paradigm

Modeling Nature’s Orchestra

Cell Technology

Engineering Functional Characteristics

Translation into the Living System

Concluding Discussion

References

Chapter 3. From Mathematical Models to Clinical Reality

Abstract

Introduction

Modeling Stem Cell Dynamics

Modeling Tissue Growth and Development

From Mathematical Models to Clinical Reality

References

Chapter 4. Stem Cells as Building Blocks

Abstract

List of Abbreviations

Introduction

Differentiation Potential of Stem Cells

Stem Cell Niche

Developmental Origin of Stem Cells

Stem Cell Differentiation Methods

Transdifferentiation and Reprogramming

Challenges and Looking Forward

References

Chapter 5. Moving into the Clinic

Abstract

Acknowledgments

Introduction

History of Clinical Tissue Engineering

Strategies to Advance toward the Clinic

Bringing technology platforms to the clinical setting

Transition to clinical testing

Clinical Trial Planning

Establishing a Regulatory Pathway

Conclusions

References

Chapter 6. Tissue Engineering: Future Perspectives

Abstract

Clinical Need

Current State of the Fi

Details

No. of pages:
1936
Language:
English
Copyright:
© 2014
Published:
Imprint:
Academic Press
Print ISBN:
9780123983589
Electronic ISBN:
9780123983701

About the authors

Robert Lanza

Robert Lanza, M.D. is currently Chief Scientific Officer at Advanced Cell Technology, and Adjunct Professor of Surgical Sciences at Wake Forest University School of Medicine. He has several hundred scientific publications and patents, and over 30 books, including Principles of Tissue Engineering (1st through 4th Editions), Methods of Tissue Engineering, Principles of Cloning (1st and 2nd Editions), Essentials of Stem Cell Biology (1st and 2nd Editions), XENO, Yearbook of Cell & Tissue Transplantation, One World: The Health & Survival of the Human Species in the 21st Century (as editor, with forewords by C. Everett Koop and former President Jimmy Carter), and Medical Science & the Advancement of World Health. Dr. Lanza received his B.A. and M.D. degrees from the University of Pennsylvania, where he was both a University Scholar and Benjamin Franklin Scholar. He is a former Fulbright Scholar, and studied as a student in the laboratory of Richard Hynes (MIT), Jonas Salk (The Salk Institute), and Nobel laureates Gerald Edelman (Rockefeller University) and Rodney Porter (Oxford University). He also worked closely (and coauthored a series of papers) with the late Harvard psychologist B.F. Skinner and heart transplant pioneer Christiaan Barnard. Dr. Lanza's current area of research focuses on the use of stem cells in regenerative medicine.

Robert Langer

Robert Langer received honorary doctorates from the ETH (Switzerland) in 1996 and the Technion (Israel) in 1997. Dr. Langer is the Kenneth J. Germeshausen Professor of Chemical and Biomedical Engineering at MIT. He received a Bachelor’s Degree from Cornell University in 1970 and a Sc.D. from MIT in 1974, both in chemical engineering. Dr. Langer has written 590 articles, 400 abstracts, 350 patents, and has edited 12 books.Dr. Langer has received over 70 major awards, including the Gairdner Foundation International Award, the Lemelson-MIT prize, the American Chemical Society (ACS) Polymer Chemistry and Applied Polymer Science Awards, Creative Polymer Chemistry Award (ACS, Polymer Division), the Pearlman Memorial Lectureship Award (ACD, Biochemical Technology Division), and the A.I.Ch.E’s Walker, Professional Progress, Bioengineering, and Stine Materials Science and Engineering Awards. In 1989, Dr. Langer was elected to the Institute of Medicine and the National Academy of Sciences, and in 1992 he was elected to both the National Academy of Engineering and to the National Academy of Sciences. He is the only active member of all 3 United States National Academies.